Manteia - Molecule gene

ENSMUSG00000015461

Mus musculus

Features

Gene ID:	ENSMUSG00000015461

Biological name :	Atf6b

Synonyms :	activating transcription factor 6 beta / Atf6b

Possible biological names infered from orthology :	Q99941

Species:	Mus musculus

Chr. number:	17
Strand:	1
Band:	B1
Gene start:	34647146
Gene end:	34655074

Corresponding Affymetrix probe sets:	10444439 (MoGene1.0st) 1417173_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000133516 Ensembl peptide - ENSMUSP00000015605 Ensembl peptide - ENSMUSP00000133558 Ensembl peptide - ENSMUSP00000133786 NCBI entrez gene - 12915 See in Manteia. MGI - MGI:105121 RefSeq - NM_017406 RefSeq Peptide - NP_059102 swissprot - G3UXQ6 swissprot - G3UX56 swissprot - G3UX19 swissprot - A0A0A0MQ69 Ensembl - ENSMUSG00000015461

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
ATF6B	ENSG00000213676	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Atf6 / F6VAN0 / Cyclic AMP-dependent transcription factor ATF-6 alpha Processed cyclic AMP-dependent transcription factor ATF-6 alpha / P18850* / activating transcription factor 6*	ENSMUSG00000026663	30

Protein motifs (from Interpro)

Interpro ID	Name
IPR004827	Basic-leucine zipper domain
IPR029809	cAMP-dependent transcription factor ATF-6 beta

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006355	regulation of transcription, DNA-templated	IEA
biological_process	GO:0006357	regulation of transcription by RNA polymerase II	IEA
biological_process	GO:0030968	endoplasmic reticulum unfolded protein response	IEA
biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	IEA
biological_process	GO:1903892	negative regulation of ATF6-mediated unfolded protein response	IEA
biological_process	GO:1990440	positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	IEA
cellular_component	GO:0005622	intracellular	IEA
cellular_component	GO:0005634	nucleus	IEA
cellular_component	GO:0005730	nucleolus	IEA
cellular_component	GO:0005789	endoplasmic reticulum membrane	IEA
cellular_component	GO:0012505	endomembrane system	IEA
cellular_component	GO:0032993	protein-DNA complex	IEA
cellular_component	GO:0090575	RNA polymerase II transcription factor complex	IEA
molecular_function	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	IEA
molecular_function	GO:0003700	DNA-binding transcription factor activity	IEA
molecular_function	GO:0035497	cAMP response element binding	IEA
molecular_function	GO:0044212	transcription regulatory region DNA binding	IEA

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0008943	increased sensitivity to induced cell death	"decrease in the exposure level to an agent that is required to induce cessation of function at the cellular level" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gabbr2^tm1Arca/Gabbr2^tm1Arca Genetic Background: involves: 129P2/OlaHsd
MP:0011091	complete prenatal lethality	"death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]	Show Allelic Composition: Gabbr2^tm1Arca/Gabbr2^tm1Arca Genetic Background: involves: 129P2/OlaHsd
MP:0011110	partial preweaning lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]	Show Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp,Gt(ROSA)26Sor^{tm1(rtTA,EGFP)Nagy}/Gt(ROSA)26Sor⁺,Pten^tm1Rdp/Pten^tm1Rdp,Tg(tetO-BRAFV600E)29Lc/0,Tg(Tyr-cre/ERT2)13Bos/0 Genetic Background:* involves: 129/Sv * C57BL/6J * FVB * SJL
MP:0011967	increased or absent threshold for auditory brainstem response	"increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]	Show Allelic Composition: Aff3^{tm1a(EUCOMM)Wtsi}/Aff3⁺ Genetic Background: C57BL/6N-Aff3^{tm1a(EUCOMM)Wtsi}/Wtsi

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr