ENSG00000072310


Homo sapiens

Features
Gene ID: ENSG00000072310
  
Biological name :SREBF1
  
Synonyms : P36956 / SREBF1 / sterol regulatory element binding transcription factor 1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: -1
Band: p11.2
Gene start: 17810399
Gene end: 17837002
  
Corresponding Affymetrix probe sets: 1558875_at (Human Genome U133 Plus 2.0 Array)   202308_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000466643
Ensembl peptide - ENSP00000466453
Ensembl peptide - ENSP00000474121
Ensembl peptide - ENSP00000261646
Ensembl peptide - ENSP00000348069
Ensembl peptide - ENSP00000379100
Ensembl peptide - ENSP00000379106
Ensembl peptide - ENSP00000411516
Ensembl peptide - ENSP00000463474
Ensembl peptide - ENSP00000464923
Ensembl peptide - ENSP00000465747
NCBI entrez gene - 6720     See in Manteia.
OMIM - 184756
RefSeq - XM_017024971
RefSeq - NM_001005291
RefSeq - NM_001321096
RefSeq - NM_004176
RefSeq - XM_005256772
RefSeq - XM_017024970
RefSeq Peptide - NP_001005291
RefSeq Peptide - NP_001308025
RefSeq Peptide - NP_004167
swissprot - B5MD58
swissprot - P36956
swissprot - F6V242
swissprot - J3QLB6
swissprot - K7EIW8
swissprot - K7EKR7
swissprot - K7EMT8
swissprot - K7EMD1
swissprot - S4R3B4
swissprot - X6RBE4
Ensembl - ENSG00000072310
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 srebf1ENSDARG00000067607Danio rerio
 SREBF1ENSGALG00000027188Gallus gallus
 Q9WTN3ENSMUSG00000020538Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q12772 / SREBF2 / sterol regulatory element binding transcription factor 2ENSG0000019891142


Protein motifs (from Interpro)
Interpro ID Name
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0003062 regulation of heart rate by chemical signal IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II TAS
 biological_processGO:0006629 lipid metabolic process TAS
 biological_processGO:0007568 aging IEA
 biological_processGO:0007623 circadian rhythm TAS
 biological_processGO:0008202 steroid metabolic process IEA
 biological_processGO:0008203 cholesterol metabolic process IEA
 biological_processGO:0008286 insulin receptor signaling pathway IEA
 biological_processGO:0008610 lipid biosynthetic process ISS
 biological_processGO:0009267 cellular response to starvation ISS
 biological_processGO:0009749 response to glucose IEA
 biological_processGO:0010867 positive regulation of triglyceride biosynthetic process ISS
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0019217 regulation of fatty acid metabolic process IEA
 biological_processGO:0030324 lung development IEA
 biological_processGO:0030522 intracellular receptor signaling pathway IEA
 biological_processGO:0031065 positive regulation of histone deacetylation IEA
 biological_processGO:0031647 regulation of protein stability IMP
 biological_processGO:0032094 response to food IEA
 biological_processGO:0032526 response to retinoic acid IEA
 biological_processGO:0032570 response to progesterone IEA
 biological_processGO:0032869 cellular response to insulin stimulus IEA
 biological_processGO:0033762 response to glucagon IEA
 biological_processGO:0033993 response to lipid IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042789 mRNA transcription by RNA polymerase II IEA
 biological_processGO:0043434 response to peptide hormone IEA
 biological_processGO:0045444 fat cell differentiation IEA
 biological_processGO:0045540 regulation of cholesterol biosynthetic process TAS
 biological_processGO:0045542 positive regulation of cholesterol biosynthetic process IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II TAS
 biological_processGO:0046676 negative regulation of insulin secretion IEA
 biological_processGO:0050796 regulation of insulin secretion IEA
 biological_processGO:0051591 response to cAMP IEA
 biological_processGO:0070542 response to fatty acid IEA
 biological_processGO:0071398 cellular response to fatty acid IEA
 biological_processGO:1903146 regulation of autophagy of mitochondrion IMP
 biological_processGO:1903214 regulation of protein targeting to mitochondrion IMP
 cellular_componentGO:0000139 Golgi membrane TAS
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005635 nuclear envelope TAS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0012507 ER to Golgi transport vesicle membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0000982 transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding ISS
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA
 molecular_functionGO:0004879 nuclear receptor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0032810 sterol response element binding IDA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
RORA activates gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000125629 INSIG2 / Q9Y5U4 / insulin induced gene 2  / complex
 ENSG00000120837 NFYB / P25208 / nuclear transcription factor Y subunit beta  / complex / reaction
 ENSG00000138802 O95487 / SEC24B / SEC24 homolog B, COPII coat complex component  / complex
 ENSG00000114650 SCAP / Q12770 / SREBF chaperone  / complex
 ENSG00000108424 KPNB1 / Q14974 / karyopherin subunit beta 1  / complex / reaction
 ENSG00000072310 P36956 / SREBF1 / sterol regulatory element binding transcription factor 1  / complex / reaction
 ENSG00000066136 NFYC / Q13952 / nuclear transcription factor Y subunit gamma  / complex / reaction
 ENSG00000132341 RAN / P62826 / RAN, member RAS oncogene family  / reaction
 ENSG00000001167 NFYA / P23511 / nuclear transcription factor Y subunit alpha  / complex / reaction
 ENSG00000198911 Q12772 / SREBF2 / sterol regulatory element binding transcription factor 2  / reaction / complex
 ENSG00000185591 SP1 / P08047 / Sp1 transcription factor  / complex / reaction
 ENSG00000100934 Q15436 / SEC23A / Sec23 homolog A, coat complex II component  / complex
 ENSG00000150961 O94855 / SEC24D / SEC24 homolog D, COPII coat complex component  / complex
 ENSG00000186480 INSIG1 / O15503 / insulin induced gene 1  / complex
 ENSG00000140943 MBTPS1 / Q14703 / membrane bound transcription factor peptidase, site 1  / reaction
 ENSG00000176986 P53992 / SEC24C / SEC24 homolog C, COPII coat complex component  / complex
 ENSG00000113615 O95486 / SEC24A / SEC24 homolog A, COPII coat complex component  / complex
 ENSG00000012174 MBTPS2 / O43462 / membrane bound transcription factor peptidase, site 2  / reaction
 ENSG00000152700 SAR1B / Q9Y6B6 / secretion associated Ras related GTPase 1B  / complex






 

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