ENSG00000125629


Homo sapiens

Features
Gene ID: ENSG00000125629
  
Biological name :INSIG2
  
Synonyms : INSIG2 / insulin induced gene 2 / Q9Y5U4
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: q14.1
Gene start: 118088452
Gene end: 118110997
  
Corresponding Affymetrix probe sets: 209566_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000400126
Ensembl peptide - ENSP00000484179
Ensembl peptide - ENSP00000245787
NCBI entrez gene - 51141     See in Manteia.
OMIM - 608660
RefSeq - NM_001321331
RefSeq - NM_001321329
RefSeq - NM_001321330
RefSeq - NM_001321332
RefSeq - NM_001321333
RefSeq - NM_016133
RefSeq Peptide - NP_001308258
RefSeq Peptide - NP_001308260
RefSeq Peptide - NP_001308261
RefSeq Peptide - NP_001308262
RefSeq Peptide - NP_001308259
RefSeq Peptide - NP_057217
swissprot - A0A024RAI2
swissprot - Q9Y5U4
swissprot - A0A0C4DGZ4
swissprot - F8WCG8
Ensembl - ENSG00000125629
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 insig2ENSDARG00000113367Danio rerio
 INSIG2ENSGALG00000028046Gallus gallus
 Insig2ENSMUSG00000003721Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
INSIG1 / O15503 / insulin induced gene 1ENSG0000018648071


Protein motifs (from Interpro)
Interpro ID Name
 IPR025929  Insulin-induced protein family


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006641 triglyceride metabolic process IEA
 biological_processGO:0006695 cholesterol biosynthetic process IEA
 biological_processGO:0006991 response to sterol depletion IEA
 biological_processGO:0008202 steroid metabolic process IEA
 biological_processGO:0008203 cholesterol metabolic process IEA
 biological_processGO:0010894 negative regulation of steroid biosynthetic process IEA
 biological_processGO:0016126 sterol biosynthetic process IEA
 biological_processGO:0032868 response to insulin IEA
 biological_processGO:0032933 SREBP signaling pathway IDA
 biological_processGO:0033993 response to lipid IEA
 biological_processGO:0042472 inner ear morphogenesis IEA
 biological_processGO:0042474 middle ear morphogenesis IEA
 biological_processGO:0045717 negative regulation of fatty acid biosynthetic process IEA
 biological_processGO:0060021 roof of mouth development IEA
 biological_processGO:0060363 cranial suture morphogenesis IEA
 biological_processGO:0070542 response to fatty acid IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0032937 SREBP-SCAP-Insig complex IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IEA


Pathways (from Reactome)
Pathway description
Regulation of cholesterol biosynthesis by SREBP (SREBF)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000072310 P36956 / SREBF1 / sterol regulatory element binding transcription factor 1  / complex
 ENSG00000125629 INSIG2 / Q9Y5U4 / insulin induced gene 2  / complex
 ENSG00000186480 INSIG1 / O15503 / insulin induced gene 1  / complex
 ENSG00000198911 Q12772 / SREBF2 / sterol regulatory element binding transcription factor 2  / complex
 ENSG00000114650 SCAP / Q12770 / SREBF chaperone  / complex






 

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