ENSG00000186480


Homo sapiens

Features
Gene ID: ENSG00000186480
  
Biological name :INSIG1
  
Synonyms : INSIG1 / insulin induced gene 1 / O15503
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: 1
Band: q36.3
Gene start: 155297776
Gene end: 155310235
  
Corresponding Affymetrix probe sets: 201625_s_at (Human Genome U133 Plus 2.0 Array)   201626_at (Human Genome U133 Plus 2.0 Array)   201627_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000420198
Ensembl peptide - ENSP00000344035
Ensembl peptide - ENSP00000344741
Ensembl peptide - ENSP00000414691
Ensembl peptide - ENSP00000340010
NCBI entrez gene - 3638     See in Manteia.
OMIM - 602055
RefSeq - XM_017012177
RefSeq - NM_001346592
RefSeq - NM_005542
RefSeq - NM_198336
RefSeq - NM_198337
RefSeq - XM_005249542
RefSeq - XM_005249543
RefSeq Peptide - NP_001333522
RefSeq Peptide - NP_005533
RefSeq Peptide - NP_938150
RefSeq Peptide - NP_938151
RefSeq Peptide - NP_001333521
swissprot - O15503
swissprot - C9JSG8
swissprot - F5H6P3
swissprot - H7C5L3
swissprot - A0A024RD68
Ensembl - ENSG00000186480
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 insig1ENSDARG00000010658Danio rerio
 INSIG1ENSGALG00000017394Gallus gallus
 Insig1ENSMUSG00000045294Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
INSIG2 / Q9Y5U4 / insulin induced gene 2ENSG0000012562958


Protein motifs (from Interpro)
Interpro ID Name
 IPR009904  Insulin-induced gene 1 protein
 IPR025929  Insulin-induced protein family


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006641 triglyceride metabolic process IEA
 biological_processGO:0006695 cholesterol biosynthetic process IEA
 biological_processGO:0006991 response to sterol depletion IEA
 biological_processGO:0008202 steroid metabolic process IEA
 biological_processGO:0008203 cholesterol metabolic process IEA
 biological_processGO:0008283 cell proliferation TAS
 biological_processGO:0010894 negative regulation of steroid biosynthetic process IEA
 biological_processGO:0016126 sterol biosynthetic process IEA
 biological_processGO:0032933 SREBP signaling pathway IDA
 biological_processGO:0036315 cellular response to sterol IMP
 biological_processGO:0036316 SREBP-SCAP complex retention in endoplasmic reticulum IDA
 biological_processGO:0042472 inner ear morphogenesis IEA
 biological_processGO:0042474 middle ear morphogenesis IEA
 biological_processGO:0042632 cholesterol homeostasis IDA
 biological_processGO:0045599 negative regulation of fat cell differentiation IEA
 biological_processGO:0045717 negative regulation of fatty acid biosynthetic process IEA
 biological_processGO:0060021 roof of mouth development IEA
 biological_processGO:0060363 cranial suture morphogenesis IEA
 biological_processGO:0070862 negative regulation of protein exit from endoplasmic reticulum IDA
 biological_processGO:1901303 negative regulation of cargo loading into COPII-coated vesicle IMP
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0032937 SREBP-SCAP-Insig complex IDA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Regulation of cholesterol biosynthesis by SREBP (SREBF)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000125629 INSIG2 / Q9Y5U4 / insulin induced gene 2  / complex
 ENSG00000114650 SCAP / Q12770 / SREBF chaperone  / complex
 ENSG00000072310 P36956 / SREBF1 / sterol regulatory element binding transcription factor 1  / complex
 ENSG00000186480 INSIG1 / O15503 / insulin induced gene 1  / complex
 ENSG00000198911 Q12772 / SREBF2 / sterol regulatory element binding transcription factor 2  / complex






 

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