ENSG00000114650


Homo sapiens

Features
Gene ID: ENSG00000114650
  
Biological name :SCAP
  
Synonyms : Q12770 / SCAP / SREBF chaperone
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: -1
Band: p21.31
Gene start: 47413694
Gene end: 47477126
  
Corresponding Affymetrix probe sets: 212329_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000409183
Ensembl peptide - ENSP00000408102
Ensembl peptide - ENSP00000415195
Ensembl peptide - ENSP00000438956
Ensembl peptide - ENSP00000423419
Ensembl peptide - ENSP00000416847
Ensembl peptide - ENSP00000265565
Ensembl peptide - ENSP00000324296
Ensembl peptide - ENSP00000401819
NCBI entrez gene - 22937     See in Manteia.
OMIM - 601510
RefSeq - XM_017005921
RefSeq - NM_001320044
RefSeq - NM_012235
RefSeq - XM_005264967
RefSeq - XM_005264968
RefSeq - XM_005264971
RefSeq - XM_011533501
RefSeq - XM_011533502
RefSeq - XM_017005918
RefSeq - XM_017005919
RefSeq - XM_017005920
RefSeq Peptide - NP_036367
RefSeq Peptide - NP_001306973
swissprot - C9JQ35
swissprot - C9JFY0
swissprot - F8W921
swissprot - F8W9W7
swissprot - F8WDP3
swissprot - F8WEH8
swissprot - Q12770
swissprot - A0A0A0MTG6
swissprot - D6RA39
Ensembl - ENSG00000114650
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 scapENSDARG00000018096Danio rerio
 SCAPENSGALG00000035768Gallus gallus
 ScapENSMUSG00000032485Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
HMGCR / P04035 / 3-hydroxy-3-methylglutaryl-CoA reductaseENSG0000011316112


Protein motifs (from Interpro)
Interpro ID Name
 IPR000731  Sterol-sensing domain
 IPR001680  WD40 repeat
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site
 IPR030225  Sterol regulatory element-binding protein cleavage-activating protein
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0008202 steroid metabolic process IEA
 biological_processGO:0008203 cholesterol metabolic process IEA
 biological_processGO:0019217 regulation of fatty acid metabolic process IEA
 biological_processGO:0032868 response to insulin IEA
 biological_processGO:0032933 SREBP signaling pathway IEA
 biological_processGO:0042304 regulation of fatty acid biosynthetic process IEA
 biological_processGO:0045540 regulation of cholesterol biosynthetic process IEA
 biological_processGO:0045541 negative regulation of cholesterol biosynthetic process NAS
 biological_processGO:0045716 positive regulation of low-density lipoprotein particle receptor biosynthetic process NAS
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005783 endoplasmic reticulum NAS
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005794 Golgi apparatus NAS
 cellular_componentGO:0012507 ER to Golgi transport vesicle membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0015485 cholesterol binding IEA
 molecular_functionGO:0051082 unfolded protein binding NAS


Pathways (from Reactome)
Pathway description
Regulation of cholesterol biosynthesis by SREBP (SREBF)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000138802 O95487 / SEC24B / SEC24 homolog B, COPII coat complex component  / complex
 ENSG00000125629 INSIG2 / Q9Y5U4 / insulin induced gene 2  / complex
 ENSG00000186480 INSIG1 / O15503 / insulin induced gene 1  / complex
 ENSG00000114650 SCAP / Q12770 / SREBF chaperone  / complex
 ENSG00000072310 P36956 / SREBF1 / sterol regulatory element binding transcription factor 1  / complex
 ENSG00000198911 Q12772 / SREBF2 / sterol regulatory element binding transcription factor 2  / complex
 ENSG00000100934 Q15436 / SEC23A / Sec23 homolog A, coat complex II component  / complex
 ENSG00000150961 O94855 / SEC24D / SEC24 homolog D, COPII coat complex component  / complex
 ENSG00000140943 MBTPS1 / Q14703 / membrane bound transcription factor peptidase, site 1  / reaction
 ENSG00000176986 P53992 / SEC24C / SEC24 homolog C, COPII coat complex component  / complex
 ENSG00000113615 O95486 / SEC24A / SEC24 homolog A, COPII coat complex component  / complex
 ENSG00000152700 SAR1B / Q9Y6B6 / secretion associated Ras related GTPase 1B  / complex






 

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