ENSDARG00000018096


Danio rerio

Features
Gene ID: ENSDARG00000018096
  
Biological name :scap
  
Synonyms : scap / SREBF chaperone
  
Possible biological names infered from orthology : Q12770 / Q6GQT6
  
Species: Danio rerio
  
Chr. number: 16
Strand: 1
Band:
Gene start: 41060161
Gene end: 41103782
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000121892
Ensembl peptide - ENSDARP00000147001
NCBI entrez gene - 558292     See in Manteia.
swissprot - E9QEH6
ZFIN ID - ZDB-GENE-040107-41
Ensembl - ENSDARG00000018096
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SCAPENSGALG00000035768Gallus gallus
 SCAPENSG00000114650Homo sapiens
 ScapENSMUSG00000032485Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
hmgcra / 3-hydroxy-3-methylglutaryl-CoA reductase a / HMGCR* / Q01237* / P04035* / 3-hydroxy-3-methylglutaryl-CoA reductase* / 3-hydroxy-3-methylglutaryl-coenzyme A reductase *ENSDARG0000005273412
hmgcrb / 3-hydroxy-3-methylglutaryl-CoA reductase bENSDARG0000010520611


Protein motifs (from Interpro)
Interpro ID Name
 IPR000731  Sterol-sensing domain
 IPR001680  WD40 repeat
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site
 IPR030225  Sterol regulatory element-binding protein cleavage-activating protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IMP
 biological_processGO:0008203 cholesterol metabolic process IEA
 biological_processGO:0019915 lipid storage IMP
 biological_processGO:0032933 SREBP signaling pathway IEA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0015485 cholesterol binding IEA


Pathways (from Reactome)
Pathway description
Regulation of cholesterol biosynthesis by SREBP (SREBF)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000123 liver liver fatty , abnormal
liver cell fatty , abnormal
liver cell fatty , ameliorated
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 ZFA:0009111 hepatocyte hepatocyte decreased functionality , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000014634 mbtps1 / membrane-bound transcription factor peptidase, site 1 / Q14703* / Q9WTZ2* / Membrane-bound transcription factor site-1 protease *  / reaction
 ENSDARG00000018096 scap / SREBF chaperone / Q12770* / Q6GQT6*  / complex






 

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