ENSDARG00000014634


Danio rerio

Features
Gene ID: ENSDARG00000014634
  
Biological name :mbtps1
  
Synonyms : mbtps1 / membrane-bound transcription factor peptidase, site 1
  
Possible biological names infered from orthology : Membrane-bound transcription factor site-1 protease / Q14703 / Q9WTZ2
  
Species: Danio rerio
  
Chr. number: 18
Strand: -1
Band:
Gene start: 21645309
Gene end: 21685055
  
Corresponding Affymetrix probe sets: Dr.7917.1.A1_at (Zebrafish Array)   NM_199213_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000007839
NCBI entrez gene - 326710     See in Manteia.
RefSeq - XM_021467593
RefSeq - NM_199213
RefSeq Peptide - NP_954683
swissprot - Q1LWH3
ZFIN ID - ZDB-GENE-030131-4909
Ensembl - ENSDARG00000014634
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MBTPS1ENSGALG00000003293Gallus gallus
 MBTPS1ENSG00000140943Homo sapiens
 Mbtps1ENSMUSG00000031835Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000209  Peptidase S8/S53 domain
 IPR015500  Peptidase S8, subtilisin-related
 IPR022398  Peptidase S8, subtilisin, His-active site
 IPR023828  Peptidase S8, subtilisin, Ser-active site
 IPR029062  Class I glutamine amidotransferase-like
 IPR034185  Site-1 peptidase catalytic domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001889 liver development IMP
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006629 lipid metabolic process IMP
 biological_processGO:0051216 cartilage development IMP
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004175 endopeptidase activity ISS
 molecular_functionGO:0004252 serine-type endopeptidase activity IEA
 molecular_functionGO:0008233 peptidase activity IEA


Pathways (from Reactome)
Pathway description
Regulation of cholesterol biosynthesis by SREBP (SREBF)
ATF6 (ATF6-alpha) activates chaperones
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
CREB3 factors activate genes
Post-translational protein phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000095 pharyngeal arch 3-7 skeleton pharyngeal arch 3-7 skeleton quality , abnormal
Show

 ZFA:0000123 liver liver circular , abnormal
liver cell fatty , abnormal
liver cell fatty , ameliorated
Show

 ZFA:0001114 head head decreased size , abnormal
head cuboid , abnormal
Show

 ZFA:0001115 trunk trunk curved dorsal , abnormal
Show

 ZFA:0001205 Meckel s cartilage Meckels cartilage decreased size , abnormal
Show

 ZFA:0001227 mandibular arch skeleton mandibular arch skeleton decreased size , abnormal
mandibular arch skeleton decreased length , abnormal
Show

 ZFA:0001501 cartilage element cartilage element collagen type II trimer aggregated , abnormal
Show

 ZFA:0001613 pharyngeal arch 3-7 pharyngeal arch 3-7 increased size , abnormal
pharyngeal arch 3-7 chondrocyte disorganized , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000090903 creb3l3b / cAMP responsive element binding protein 3-like 3b / Q68CJ9* / Q91XE9* / CREB3L3* / cAMP responsive element binding protein 3 like 3* / Cyclic AMP-responsive element-binding prote...  / reaction
 ENSDARG00000012656 atf6 / activating transcription factor 6 / F6VAN0* / P18850* / Cyclic AMP-dependent transcription factor ATF-6 alpha Processed cyclic AMP-dependent transcription factor ATF-6 alpha*  / reaction
 ENSDARG00000018096 scap / SREBF chaperone / Q12770* / Q6GQT6*  / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr