Manteia

ENSMUSG00000032485

Mus musculus

Features

Gene ID:	ENSMUSG00000032485

Biological name :	Scap

Synonyms :	Q6GQT6 / Scap / SREBF chaperone

Possible biological names infered from orthology :	Q12770

Species:	Mus musculus

Chr. number:	9
Strand:	1
Band:	F2
Gene start:	110333288
Gene end:	110384950

Corresponding Affymetrix probe sets:	10589511 (MoGene1.0st) 1433520_at (Mouse Genome 430 2.0 Array) 1442885_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000142919 Ensembl peptide - ENSMUSP00000143710 Ensembl peptide - ENSMUSP00000143369 Ensembl peptide - ENSMUSP00000095953 Ensembl peptide - ENSMUSP00000142458 NCBI entrez gene - 235623 See in Manteia. MGI - MGI:2135958 RefSeq - XM_006512083 RefSeq - XM_006512085 RefSeq - XM_006512084 RefSeq - NM_001001144 RefSeq - NM_001103162 RefSeq Peptide - NP_001001144 RefSeq Peptide - NP_001096632 swissprot - Q6GQT6 swissprot - A0A0G2JFZ9 swissprot - A0A0G2JDQ3 swissprot - A0A0G2JEV4 Ensembl - ENSMUSG00000032485

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
scap	ENSDARG00000018096	Danio rerio
SCAP	ENSGALG00000035768	Gallus gallus
SCAP	ENSG00000114650	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Hmgcr / Q01237 / 3-hydroxy-3-methylglutaryl-coenzyme A reductase / P04035* / 3-hydroxy-3-methylglutaryl-CoA reductase*	ENSMUSG00000021670	12

Protein motifs (from Interpro)

Interpro ID	Name
IPR000731	Sterol-sensing domain
IPR001680	WD40 repeat
IPR015943	WD40/YVTN repeat-like-containing domain superfamily
IPR017986	WD40-repeat-containing domain
IPR019775	WD40 repeat, conserved site
IPR030225	Sterol regulatory element-binding protein cleavage-activating protein
IPR036322	WD40-repeat-containing domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0001666	response to hypoxia	IMP
biological_process	GO:0006629	lipid metabolic process	IEA
biological_process	GO:0007568	aging	IEA
biological_process	GO:0008202	steroid metabolic process	IEA
biological_process	GO:0008203	cholesterol metabolic process	IEA
biological_process	GO:0019217	regulation of fatty acid metabolic process	IDA
biological_process	GO:0032868	response to insulin	IMP
biological_process	GO:0032933	SREBP signaling pathway	IEA
biological_process	GO:0042304	regulation of fatty acid biosynthetic process	IMP
biological_process	GO:0045540	regulation of cholesterol biosynthetic process	IMP
cellular_component	GO:0000139	Golgi membrane	IEA
cellular_component	GO:0005783	endoplasmic reticulum	IEA
cellular_component	GO:0005789	endoplasmic reticulum membrane	IEA
cellular_component	GO:0005794	Golgi apparatus	IEA
cellular_component	GO:0012507	ER to Golgi transport vesicle membrane	IEA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016021	integral component of membrane	IEA
cellular_component	GO:0031410	cytoplasmic vesicle	IEA
cellular_component	GO:0043231	intracellular membrane-bounded organelle	IEA
molecular_function	GO:0005515	protein binding	IEA
molecular_function	GO:0015485	cholesterol binding	IEA

Pathways (from Reactome)

Pathway description

Regulation of cholesterol biosynthesis by SREBP (SREBF)

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0001265	reduced body size	"smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]	Show Allelic Composition: Hsp90aa1^{Tg(Tyr)2396BOve}/Hsp90aa1^{Tg(Tyr)2396BOve} Genetic Background: FVB/N-Hsp90aa1^{Tg(Tyr)2396BOve}
MP:0002118	abnormal lipid homeostasis	"anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Il21r^tm1Kopf/Il21r^tm1Kopf Genetic Background: B6.129-Il21r^tm1Kopf
MP:0002702	decreased circulating free fatty acid level	"lower than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Il21r^tm1Kopf/Il21r^tm1Kopf Genetic Background: B6.129-Il21r^tm1Kopf
MP:0005278	abnormal cholesterol homeostasis	"anomaly in the state of equilibrium in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:71350]	Show Allelic Composition: Il21r^tm1Kopf/Il21r^tm1Kopf Genetic Background: B6.129-Il21r^tm1Kopf
MP:0009356	decreased liver triglyceride level	"lower than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Il21r^tm1Kopf/Il21r^tm1Kopf Genetic Background: B6.129-Il21r^tm1Kopf
MP:0010026	decreased liver cholesterol level	"less than normal amount in the liver of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Il21r^tm1Kopf/Il21r^tm1Kopf Genetic Background: B6.129-Il21r^tm1Kopf

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000031835	Mbtps1 / Q9WTZ2 / Membrane-bound transcription factor site-1 protease / Q14703* / membrane bound transcription factor peptidase, site 1*	/ reaction
ENSMUSG00000032485	Scap / Q6GQT6 / SREBF chaperone / Q12770*	/ complex
ENSMUSG00000020538	Q9WTN3 / Srebf1 / Mus musculus sterol regulatory element binding transcription factor 1 (Srebf1), transcript variant 4, mRNA. / P36956* / sterol regulatory element binding transcription factor 1*	/ complex
ENSMUSG00000022463	Q3U1N2 / Srebf2 / sterol regulatory element binding factor 2 / Q12772* / sterol regulatory element binding transcription factor 2*	/ complex

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr