ENSG00000138802


Homo sapiens

Features
Gene ID: ENSG00000138802
  
Biological name :SEC24B
  
Synonyms : O95487 / SEC24B / SEC24 homolog B, COPII coat complex component
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: 1
Band: q25
Gene start: 109433772
Gene end: 109540896
  
Corresponding Affymetrix probe sets: 202798_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000265175
Ensembl peptide - ENSP00000382051
Ensembl peptide - ENSP00000428564
NCBI entrez gene - 10427     See in Manteia.
OMIM - 607184
RefSeq - NM_006323
RefSeq - XM_017007652
RefSeq - NM_001042734
RefSeq - NM_001300813
RefSeq - NM_001318085
RefSeq - NM_001318086
RefSeq - XM_005262691
RefSeq - XM_011531535
RefSeq - XM_011531536
RefSeq - XM_011531537
RefSeq - XM_011531539
RefSeq - XM_011531540
RefSeq - XM_005262688
RefSeq Peptide - NP_001287742
RefSeq Peptide - NP_001305014
RefSeq Peptide - NP_001305015
RefSeq Peptide - NP_006314
RefSeq Peptide - NP_001036199
swissprot - O95487
Ensembl - ENSG00000138802
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sec24bENSDARG00000071906Danio rerio
 SEC24BENSGALG00000035482Gallus gallus
 Sec24bENSMUSG00000001052Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O95486 / SEC24A / SEC24 homolog A, COPII coat complex componentENSG0000011361551
P53992 / SEC24C / SEC24 homolog C, COPII coat complex componentENSG0000017698624
O94855 / SEC24D / SEC24 homolog D, COPII coat complex componentENSG0000015096123


Protein motifs (from Interpro)
Interpro ID Name
 IPR006895  Zinc finger, Sec23/Sec24-type
 IPR006896  Sec23/Sec24, trunk domain
 IPR006900  Sec23/Sec24, helical domain
 IPR007123  Gelsolin-like domain
 IPR012990  Sec23/Sec24 beta-sandwich
 IPR029006  ADF-H/Gelsolin-like domain superfamily
 IPR036174  Zinc finger, Sec23/Sec24-type superfamily
 IPR036175  Sec23/Sec24 helical domain superfamily
 IPR036180  Gelsolin-like domain superfamily
 IPR036465  von Willebrand factor A-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001843 neural tube closure IEA
 biological_processGO:0002093 auditory receptor cell morphogenesis IEA
 biological_processGO:0002474 antigen processing and presentation of peptide antigen via MHC class I TAS
 biological_processGO:0003151 outflow tract morphogenesis IEA
 biological_processGO:0006886 intracellular protein transport IEA
 biological_processGO:0006888 ER to Golgi vesicle-mediated transport TAS
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016192 vesicle-mediated transport IEA
 biological_processGO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II TAS
 biological_processGO:0021747 cochlear nucleus development IEA
 biological_processGO:0035909 aorta morphogenesis IEA
 biological_processGO:0048208 COPII vesicle coating TAS
 biological_processGO:0060088 auditory receptor cell stereocilium organization IEA
 biological_processGO:0060425 lung morphogenesis IEA
 biological_processGO:0060463 lung lobe morphogenesis IEA
 biological_processGO:0060982 coronary artery morphogenesis IEA
 biological_processGO:0061156 pulmonary artery morphogenesis IEA
 biological_processGO:0072358 cardiovascular system development IEA
 biological_processGO:0090110 cargo loading into COPII-coated vesicle IDA
 biological_processGO:0090178 regulation of establishment of planar polarity involved in neural tube closure IEA
 biological_processGO:1901301 regulation of cargo loading into COPII-coated vesicle IEA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0012507 ER to Golgi transport vesicle membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030127 COPII vesicle coat IDA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IDA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Regulation of cholesterol biosynthesis by SREBP (SREBF)
COPII-mediated vesicle transport
MHC class II antigen presentation
Cargo concentration in the ER
Antigen Presentation: Folding, assembly and peptide loading of class I MHC


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000114354 TFG / Q92734 / TRK-fused gene  / complex / reaction
 ENSG00000120341 Q96JE7 / SEC16B / SEC16 homolog B, endoplasmic reticulum export factor  / complex / reaction
 ENSG00000138674 O94979 / SEC31A / SEC31 homolog A, COPII coat complex component  / reaction / complex
 ENSG00000167110 GOLGA2 / Q08379 / golgin A2  / complex / reaction
 ENSG00000072310 P36956 / SREBF1 / sterol regulatory element binding transcription factor 1  / complex
 ENSG00000114745 Q9BQQ3 / GORASP1 / golgi reassembly stacking protein 1  / reaction / complex
 ENSG00000157020 SEC13 / P55735 / SEC13 homolog, nuclear pore and COPII coat complex component  / complex / reaction
 ENSG00000138802 O95487 / SEC24B / SEC24 homolog B, COPII coat complex component  / complex
 ENSG00000198911 Q12772 / SREBF2 / sterol regulatory element binding transcription factor 2  / complex
 ENSG00000231389 P20036 / HLA-DPA1 / major histocompatibility complex, class II, DP alpha 1  / reaction / complex
 ENSG00000196735 P01909 / HLA-DQA1 / major histocompatibility complex, class II, DQ alpha 1  / reaction / complex
 ENSG00000114650 SCAP / Q12770 / SREBF chaperone  / complex
 ENSG00000138069 RAB1A / P62820 / RAB1A, member RAS oncogene family  / complex / reaction
 ENSG00000204287 P01903 / HLA-DRA / major histocompatibility complex, class II, DR alpha  / reaction / complex
 ENSG00000166710 B2M / P61769 / beta-2-microglobulin  / complex / reaction
 ENSG00000237541 P01906 / HLA-DQA2 / major histocompatibility complex, class II, DQ alpha 2  / reaction / complex
 ENSG00000148396 O15027 / SEC16A / SEC16 homolog A, endoplasmic reticulum export factor  / complex / reaction
 ENSG00000152700 SAR1B / Q9Y6B6 / secretion associated Ras related GTPase 1B  / complex / reaction
 ENSG00000019582 CD74 / P04233 / CD74 molecule  / reaction / complex
 ENSG00000100934 Q15436 / SEC23A / Sec23 homolog A, coat complex II component  / reaction / complex
 ENSG00000176986 P53992 / SEC24C / SEC24 homolog C, COPII coat complex component  / complex
 ENSG00000138768 USO1 / O60763 / USO1 vesicle transport factor  / complex / reaction
 ENSG00000141551 CSNK1D / P48730 / casein kinase 1 delta  / reaction
 ENSG00000150961 O94855 / SEC24D / SEC24 homolog D, COPII coat complex component  / complex
 ENSG00000113615 O95486 / SEC24A / SEC24 homolog A, COPII coat complex component  / complex
 ENSG00000107651 Q9Y6Y8 / SEC23IP / SEC23 interacting protein  / reaction / complex
 ENSG00000119414 PPP6C / O00743 / protein phosphatase 6 catalytic subunit  / reaction
 ENSG00000265808 O75396 / SEC22B / SEC22 homolog B, vesicle trafficking protein (gene/pseudogene)  / reaction / complex






 

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