ENSG00000265808


Homo sapiens

Features
Gene ID: ENSG00000265808
  
Biological name :SEC22B
  
Synonyms : O75396 / SEC22B / SEC22 homolog B, vesicle trafficking protein (gene/pseudogene)
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: p12
Gene start: 120150898
Gene end: 120176515
  
Corresponding Affymetrix probe sets: 209206_at (Human Genome U133 Plus 2.0 Array)   209207_s_at (Human Genome U133 Plus 2.0 Array)   214257_s_at (Human Genome U133 Plus 2.0 Array)   231890_at (Human Genome U133 Plus 2.0 Array)   233020_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000484017
Ensembl peptide - ENSP00000463393
NCBI entrez gene - 9554     See in Manteia.
OMIM - 604029
RefSeq - XM_017002857
RefSeq - NM_004892
RefSeq - XM_017002856
RefSeq Peptide - NP_004883
swissprot - O75396
swissprot - A0A087X1A9
Ensembl - ENSG00000265808
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q7SXP0ENSDARG00000100435Danio rerio
 sec22baENSDARG00000030108Danio rerio
 Q5ZJW4ENSGALG00000039704Gallus gallus
 O08547ENSMUSG00000027879Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q96IW7 / SEC22A / SEC22 homolog A, vesicle trafficking proteinENSG0000012154232
Q9BRL7 / SEC22C / SEC22 homolog C, vesicle trafficking proteinENSG0000009318323


Protein motifs (from Interpro)
Interpro ID Name
 IPR001388  Synaptobrevin
 IPR010908  Longin domain
 IPR011012  Longin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS
 biological_processGO:0006888 ER to Golgi vesicle-mediated transport TAS
 biological_processGO:0006890 retrograde vesicle-mediated transport, Golgi to ER TAS
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016192 vesicle-mediated transport IEA
 biological_processGO:0045732 positive regulation of protein catabolic process IMP
 biological_processGO:0048208 COPII vesicle coating TAS
 biological_processGO:0048280 vesicle fusion with Golgi apparatus IBA
 biological_processGO:1902902 negative regulation of autophagosome assembly IMP
 biological_processGO:1990668 vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane TAS
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0005793 endoplasmic reticulum-Golgi intermediate compartment IDA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0012507 ER to Golgi transport vesicle membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030133 transport vesicle TAS
 cellular_componentGO:0030670 phagocytic vesicle membrane TAS
 cellular_componentGO:0031201 SNARE complex IBA
 cellular_componentGO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane IEA
 cellular_componentGO:0042470 melanosome IEA
 molecular_functionGO:0000149 SNARE binding IBA
 molecular_functionGO:0005484 SNAP receptor activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019905 syntaxin binding IEA


Pathways (from Reactome)
Pathway description
ER-Phagosome pathway
COPII-mediated vesicle transport
Cargo concentration in the ER
COPI-dependent Golgi-to-ER retrograde traffic


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000108433 GOSR2 / O14653 / golgi SNAP receptor complex member 2  / complex / reaction
 ENSG00000105829 BET1 / O15155 / Bet1 golgi vesicular membrane trafficking protein  / reaction / complex
 ENSG00000138674 O94979 / SEC31A / SEC31 homolog A, COPII coat complex component  / reaction / complex
 ENSG00000105402 NAPA / P54920 / NSF attachment protein alpha  / reaction / complex
 ENSG00000138768 USO1 / O60763 / USO1 vesicle transport factor  / reaction / complex
 ENSG00000162236 STX5 / Q13190 / syntaxin 5  / complex / reaction
 ENSG00000141551 CSNK1D / P48730 / casein kinase 1 delta  / reaction
 ENSG00000100934 Q15436 / SEC23A / Sec23 homolog A, coat complex II component  / complex / reaction
 ENSG00000103496 STX4 / Q12846 / syntaxin 4  / complex
 ENSG00000092108 SCFD1 / Q8WVM8 / sec1 family domain containing 1  / complex / reaction
 ENSG00000157020 SEC13 / P55735 / SEC13 homolog, nuclear pore and COPII coat complex component  / complex / reaction
 ENSG00000107651 Q9Y6Y8 / SEC23IP / SEC23 interacting protein  / complex / reaction
 ENSG00000138069 RAB1A / P62820 / RAB1A, member RAS oncogene family  / complex / reaction
 ENSG00000073969 NSF / P46459 / N-ethylmaleimide sensitive factor, vesicle fusing ATPase  / complex / reaction
 ENSG00000167110 GOLGA2 / Q08379 / golgin A2  / complex / reaction
 ENSG00000168818 STX18 / Q9P2W9 / syntaxin 18  / complex
 ENSG00000114354 TFG / Q92734 / TRK-fused gene  / reaction / complex
 ENSG00000150961 O94855 / SEC24D / SEC24 homolog D, COPII coat complex component  / reaction / complex
 ENSG00000204267 TAP2 / Q03519 / transporter 2, ATP binding cassette subfamily B member  / reaction
 ENSG00000113734 BNIP1 / Q12981 / BCL2 interacting protein 1  / complex
 ENSG00000113615 O95486 / SEC24A / SEC24 homolog A, COPII coat complex component  / complex / reaction
 ENSG00000138802 O95487 / SEC24B / SEC24 homolog B, COPII coat complex component  / reaction / complex
 ENSG00000120341 Q96JE7 / SEC16B / SEC16 homolog B, endoplasmic reticulum export factor  / complex / reaction
 ENSG00000148396 O15027 / SEC16A / SEC16 homolog A, endoplasmic reticulum export factor  / complex / reaction
 ENSG00000231925 TAPBP / O15533 / TAP binding protein  / reaction
 ENSG00000114745 Q9BQQ3 / GORASP1 / golgi reassembly stacking protein 1  / reaction / complex
 ENSG00000168394 TAP1 / Q03518 / transporter 1, ATP binding cassette subfamily B member  / reaction
 ENSG00000179218 CALR / P27797 / calreticulin  / reaction
 ENSG00000176986 P53992 / SEC24C / SEC24 homolog C, COPII coat complex component  / reaction / complex
 ENSG00000152700 SAR1B / Q9Y6B6 / secretion associated Ras related GTPase 1B  / reaction / complex
 ENSG00000053501 USE1 / Q9NZ43 / unconventional SNARE in the ER 1  / complex






 

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