ENSG00000120837


Homo sapiens

Features
Gene ID: ENSG00000120837
  
Biological name :NFYB
  
Synonyms : NFYB / nuclear transcription factor Y subunit beta / P25208
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: -1
Band: q23.3
Gene start: 104117077
Gene end: 104138289
  
Corresponding Affymetrix probe sets: 218127_at (Human Genome U133 Plus 2.0 Array)   218128_at (Human Genome U133 Plus 2.0 Array)   218129_s_at (Human Genome U133 Plus 2.0 Array)   244704_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000448250
Ensembl peptide - ENSP00000240055
Ensembl peptide - ENSP00000447486
NCBI entrez gene - 4801     See in Manteia.
OMIM - 189904
RefSeq - XM_005268910
RefSeq - NM_006166
RefSeq - XM_005268908
RefSeq - XM_005268909
RefSeq Peptide - NP_006157
swissprot - P25208
swissprot - F8VSL3
swissprot - A0A024RBG7
Ensembl - ENSG00000120837
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nfybaENSDARG00000039185Danio rerio
 nfybbENSDARG00000045611Danio rerio
 NFYBENSGALG00000041193Gallus gallus
 NfybENSMUSG00000020248Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
POLE3 / Q9NRF9 / DNA polymerase epsilon 3, accessory subunitENSG0000014822920


Protein motifs (from Interpro)
Interpro ID Name
 IPR003956  Transcription factor, NFYB/HAP3, conserved site
 IPR003958  Transcription factor CBF/NF-Y/archaeal histone domain
 IPR009072  Histone-fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0045540 regulation of cholesterol biosynthetic process TAS
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:1990830 cellular response to leukemia inhibitory factor IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0016602 CCAAT-binding factor complex IDA
 cellular_componentGO:0032993 protein-DNA complex IDA
 cellular_componentGO:0090575 RNA polymerase II transcription factor complex IDA
 molecular_functionGO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IDA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0070491 repressing transcription factor binding IPI


Pathways (from Reactome)
Pathway description
PPARA activates gene expression
Activation of gene expression by SREBF (SREBP)
ATF4 activates genes
ATF6 (ATF6-alpha) activates chaperone genes


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000072310 P36956 / SREBF1 / sterol regulatory element binding transcription factor 1  / complex / reaction
 ENSG00000198911 Q12772 / SREBF2 / sterol regulatory element binding transcription factor 2  / reaction / complex
 ENSG00000185591 SP1 / P08047 / Sp1 transcription factor  / complex / reaction
 ENSG00000066136 NFYC / Q13952 / nuclear transcription factor Y subunit gamma  / complex
 ENSG00000001167 NFYA / P23511 / nuclear transcription factor Y subunit alpha  / complex






 

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