ENSG00000001167


Homo sapiens

Features
Gene ID: ENSG00000001167
  
Biological name :NFYA
  
Synonyms : NFYA / nuclear transcription factor Y subunit alpha / P23511
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: 1
Band: p21.1
Gene start: 41072945
Gene end: 41099976
  
Corresponding Affymetrix probe sets: 204107_at (Human Genome U133 Plus 2.0 Array)   204108_at (Human Genome U133 Plus 2.0 Array)   204109_s_at (Human Genome U133 Plus 2.0 Array)   215720_s_at (Human Genome U133 Plus 2.0 Array)   228431_at (Human Genome U133 Plus 2.0 Array)   228433_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000345702
Ensembl peptide - ENSP00000229418
NCBI entrez gene - 4800     See in Manteia.
OMIM - 189903
RefSeq - NM_002505
RefSeq - NM_021705
RefSeq Peptide - NP_002496
RefSeq Peptide - NP_068351
swissprot - P23511
swissprot - A0A024RD22
Ensembl - ENSG00000001167
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nfyaENSDARG00000042004Danio rerio
 nfyalENSDARG00000001621Danio rerio
 NFYAENSGALG00000003247Gallus gallus
 NfyaENSMUSG00000023994Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001289  Nuclear transcription factor Y subunit A
 IPR018362  CCAAT-binding factor, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IDA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006366 transcription by RNA polymerase II TAS
 biological_processGO:0045540 regulation of cholesterol biosynthetic process TAS
 biological_processGO:0045893 positive regulation of transcription, DNA-templated ISS
 biological_processGO:0048511 rhythmic process IEA
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0016602 CCAAT-binding factor complex IDA
 cellular_componentGO:0032993 protein-DNA complex IDA
 cellular_componentGO:0090575 RNA polymerase II transcription factor complex IDA
 molecular_functionGO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001046 core promoter sequence-specific DNA binding ISS
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0044212 transcription regulatory region DNA binding IDA


Pathways (from Reactome)
Pathway description
PPARA activates gene expression
Activation of gene expression by SREBF (SREBP)
ATF4 activates genes
ATF6 (ATF6-alpha) activates chaperone genes


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000072310 P36956 / SREBF1 / sterol regulatory element binding transcription factor 1  / complex / reaction
 ENSG00000066136 NFYC / Q13952 / nuclear transcription factor Y subunit gamma  / complex
 ENSG00000198911 Q12772 / SREBF2 / sterol regulatory element binding transcription factor 2  / reaction / complex
 ENSG00000185591 SP1 / P08047 / Sp1 transcription factor  / complex / reaction
 ENSG00000120837 NFYB / P25208 / nuclear transcription factor Y subunit beta  / complex






 

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