ENSGALG00000041687


Gallus gallus

Features
Gene ID: ENSGALG00000041687
  
Biological name :SREBF2
  
Synonyms : SREBF2 / sterol regulatory element binding transcription factor 2
  
Possible biological names infered from orthology : Q12772 / Q3U1N2 / sterol regulatory element binding factor 2
  
Species: Gallus gallus
  
Chr. number: 1
Strand: -1
Band:
Gene start: 49527794
Gene end: 49546551
  
Corresponding Affymetrix probe sets: Gga.4753.1.S1_a_at (Chicken Array)   Gga.4949.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000057563
NCBI entrez gene - 395304     See in Manteia.
RefSeq - XM_015289037
swissprot - A0A1D5PX69
Ensembl - ENSGALG00000041687
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 srebf2ENSDARG00000063438Danio rerio
 Q12772ENSG00000198911Homo sapiens
 Q3U1N2ENSMUSG00000022463Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SREBF1 / sterol regulatory element-binding protein 1 / Q9WTN3* / P36956* / sterol regulatory element binding transcription factor 1* / Mus musculus sterol regulatory element binding transc...ENSGALG0000002718844


Protein motifs (from Interpro)
Interpro ID Name
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0009267 cellular response to starvation IEA
 biological_processGO:0010886 positive regulation of cholesterol storage IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0071404 cellular response to low-density lipoprotein particle stimulus IEA
 biological_processGO:0072368 regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter IEA
 biological_processGO:0090370 negative regulation of cholesterol efflux IEA
 biological_processGO:1903146 regulation of autophagy of mitochondrion IEA
 biological_processGO:1903955 positive regulation of protein targeting to mitochondrion IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0032937 SREBP-SCAP-Insig complex IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA
 molecular_functionGO:0046983 protein dimerization activity IEA
 molecular_functionGO:0070888 E-box binding IEA


Pathways (from Reactome)
Pathway description
Regulation of cholesterol biosynthesis by SREBP (SREBF)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000002569 RAN / P42558 / GTP-binding nuclear protein Ran / P62826* / P62827* / Q61820* / Rasl2-9* / 1700009N14Rik* / RIKEN cDNA 1700009N14 gene* / RAS-like, family 2, locus 9* / RAN, member RAS onco...  / reaction
 ENSGALG00000003293 MBTPS1 / membrane bound transcription factor peptidase, site 1 / Q14703* / Q9WTZ2* / Membrane-bound transcription factor site-1 protease *  / reaction
 ENSGALG00000016382 MBTPS2 / membrane bound transcription factor peptidase, site 2 / Q8CHX6* / O43462* / Q3TTC2* / Membrane-bound transcription factor site-2 protease *  / reaction
 ENSGALG00000041687 SREBF2 / sterol regulatory element binding transcription factor 2 / Q12772* / Q3U1N2* / sterol regulatory element binding factor 2*  / reaction / complex






 

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