ENSDARG00000057026


Danio rerio

Features
Gene ID: ENSDARG00000057026
  
Biological name :ran
  
Synonyms : P79735 / ran / RAN, member RAS oncogene family
  
Possible biological names infered from orthology : 1700009N14Rik / GTP-binding nuclear protein Ran / P62826 / P62827 / Q61820 / Rasl2-9 / RAS-like, family 2, locus 9 / RIKEN cDNA 1700009N14 gene
  
Species: Danio rerio
  
Chr. number: 14
Strand: 1
Band:
Gene start: 21685537
Gene end: 21693914
  
Corresponding Affymetrix probe sets: Dr.321.1.S1_at (Zebrafish Array)   NM_131309_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000032532
Ensembl peptide - ENSDARP00000108629
Ensembl peptide - ENSDARP00000121831
NCBI entrez gene - 30572     See in Manteia.
RefSeq - NM_131309
RefSeq Peptide - NP_571384
swissprot - P79735
swissprot - Q6GTE7
ZFIN ID - ZDB-GENE-990415-88
Ensembl - ENSDARG00000057026
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 RANENSGALG00000002569Gallus gallus
 RANENSG00000132341Homo sapiens
 1700009N14RikENSMUSG00000028287Mus musculus
 Q61820ENSMUSG00000083649Mus musculus
 RanENSMUSG00000029430Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
rabl2 / RAB, member of RAS oncogene family-like 2 / RABL2A* / RABL2B* / E9Q9D5* / Q9UBK7* / Q9UNT1* / Rab-like protein 2A * / RAB, member of RAS oncogene family like 2A* / RAB, member of RA...ENSDARG0000006332126


Protein motifs (from Interpro)
Interpro ID Name
 IPR001806  Small GTPase superfamily
 IPR002041  Ran GTPase
 IPR005225  Small GTP-binding protein domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000054 ribosomal subunit export from nucleus IBA
 biological_processGO:0000070 mitotic sister chromatid segregation ISS
 biological_processGO:0003407 neural retina development IMP
 biological_processGO:0006606 protein import into nucleus ISS
 biological_processGO:0006913 nucleocytoplasmic transport IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0046039 GTP metabolic process ISS
 biological_processGO:0060041 retina development in camera-type eye IMP
 biological_processGO:0061015 snRNA import into nucleus ISS
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005635 nuclear envelope IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding ISS
 molecular_functionGO:0003924 GTPase activity ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding ISS
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Regulation of cholesterol biosynthesis by SREBP (SREBF)
Transcriptional regulation by small RNAs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000024 retinal ganglion cell layer retinal ganglion cell layer absent , abnormal
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 ZFA:0000107 eye eye decreased size , abnormal
eye decreased distribution , abnormal
eye cell proliferation decreased occurrence , abnormal
eye absent , abnormal
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 ZFA:0001114 head head deformed , abnormal
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 ZFA:0001117 post-vent region post-vent region decreased length , abnormal
post-vent region bent , abnormal
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 ZFA:0001289 ciliary marginal zone ciliary marginal zone absent , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000058159 ipo8 / importin 8 / O15397* / Q7TMY7*  / reaction / complex
 ENSDARG00000104889 kpnb1 / karyopherin (importin) beta 1 / Q14974* / P70168* / Importin subunit beta-1 * / karyopherin subunit beta 1*  / reaction / complex






 

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