ENSG00000100211


Homo sapiens

Features
Gene ID: ENSG00000100211
  
Biological name :CBY1
  
Synonyms : CBY1 / chibby family member 1, beta catenin antagonist / Q9Y3M2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 22
Strand: 1
Band: q13.1
Gene start: 38656636
Gene end: 38673854
  
Corresponding Affymetrix probe sets: 203450_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000216029
Ensembl peptide - ENSP00000478962
Ensembl peptide - ENSP00000413934
Ensembl peptide - ENSP00000412260
Ensembl peptide - ENSP00000380026
NCBI entrez gene - 25776     See in Manteia.
OMIM - 607757
RefSeq - NM_001002880
RefSeq - NM_015373
RefSeq Peptide - NP_001002880
RefSeq Peptide - NP_056188
swissprot - Q9Y3M2
swissprot - B0QY53
swissprot - A0A087WUW0
swissprot - A0A024R1L9
swissprot - B0QY54
Ensembl - ENSG00000100211
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cby1ENSDARG00000077409Danio rerio
 CBY1ENSGALG00000012218Gallus gallus
 1 ENSMUSG00000022428Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CBY3 / A6NI87 / chibby family member 3ENSG0000020465928


Protein motifs (from Interpro)
Interpro ID Name
 IPR028118  Chibby family


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008104 protein localization IMP
 biological_processGO:0030030 cell projection organization IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030178 negative regulation of Wnt signaling pathway IDA
 biological_processGO:0045444 fat cell differentiation IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0051289 protein homotetramerization IDA
 biological_processGO:0055007 cardiac muscle cell differentiation IEA
 biological_processGO:0060271 cilium assembly IEA
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005802 trans-Golgi network IDA
 cellular_componentGO:0005814 centriole IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0016607 nuclear speck IEA
 cellular_componentGO:0036064 ciliary basal body IEA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008013 beta-catenin binding IPI
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IDA


Pathways (from Reactome)
Pathway description
Deactivation of the beta-catenin transactivating complex


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000082898 XPO1 / O14980 / exportin 1  / complex / reaction
 ENSG00000168036 CTNNB1 / P35222 / catenin beta 1  / complex / reaction
 ENSG00000105221 AKT2 / P31751 / AKT serine/threonine kinase 2  / reaction
 ENSG00000142208 AKT1 / P31749 / AKT serine/threonine kinase 1  / reaction
 ENSG00000164924 YWHAZ / P63104 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta  / complex / reaction






 

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