ENSMUSG00000028145


Mus musculus

Features
Gene ID: ENSMUSG00000028145
  
Biological name :Them4
  
Synonyms : Acyl-coenzyme A thioesterase THEM4 / Q3UUI3 / Them4
  
Possible biological names infered from orthology : Q5T1C6 / thioesterase superfamily member 4
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: F2.1
Gene start: 94310089
Gene end: 94332540
  
Corresponding Affymetrix probe sets: 10494007 (MoGene1.0st)   1427055_at (Mouse Genome 430 2.0 Array)   1431140_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000062841
NCBI entrez gene - 75778     See in Manteia.
MGI - MGI:1923028
RefSeq - NM_029431
RefSeq - XM_006502236
RefSeq Peptide - NP_083707
swissprot - Q3UUI3
Ensembl - ENSMUSG00000028145
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 them4ENSDARG00000061621Danio rerio
 THEM4ENSG00000159445Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Them5 / Q9CQJ0 / thioesterase superfamily member 5 / Q8N1Q8*ENSMUSG0000002814836


Protein motifs (from Interpro)
Interpro ID Name
 IPR006683  Thioesterase domain
 IPR029069  HotDog domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006631 fatty acid metabolic process ISO
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0016032 viral process IEA
 biological_processGO:0043491 protein kinase B signaling IEA
 biological_processGO:1902108 regulation of mitochondrial membrane permeability involved in apoptotic process IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005743 mitochondrial inner membrane IEA
 cellular_componentGO:0005758 mitochondrial intermembrane space IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0032587 ruffle membrane IEA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0016290 palmitoyl-CoA hydrolase activity ISO
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0102991 myristoyl-CoA hydrolase activity IEA


Pathways (from Reactome)
Pathway description
PIP3 activates AKT signaling
Activation of AKT2
Negative regulation of the PI3K/AKT network
CD28 dependent PI3K/Akt signaling
VEGFR2 mediated vascular permeability
Mitochondrial Fatty Acid Beta-Oxidation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000607 abnormal hepatocyte morphology "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Rasgrf1tm1Toc/Rasgrf1tm1Toc
Genetic Background: involves: 129/Sv

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000001729 Akt1 / P31750 / Mus musculus thymoma viral proto-onco 1 (Akt1), transcript variant 3, mRNA. / P31749* / AKT serine/threonine kinase 1*  / reaction / complex
 ENSMUSG00000004056 Akt2 / Q60823 / Mus musculus thymoma viral proto-onco 2 (Akt2), transcript variant 4, mRNA. / P31751* / AKT serine/threonine kinase 2*  / complex
 ENSMUSG00000028145 Them4 / Q3UUI3 / Acyl-coenzyme A thioesterase THEM4 / Q5T1C6* / thioesterase superfamily member 4*  / complex






 

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© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr