ENSG00000159445


Homo sapiens

Features
Gene ID: ENSG00000159445
  
Biological name :THEM4
  
Synonyms : Q5T1C6 / THEM4 / thioesterase superfamily member 4
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: q21.3
Gene start: 151873584
Gene end: 151909808
  
Corresponding Affymetrix probe sets: 1553118_at (Human Genome U133 Plus 2.0 Array)   229253_at (Human Genome U133 Plus 2.0 Array)   243492_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000357804
Ensembl peptide - ENSP00000433304
Ensembl peptide - ENSP00000431288
NCBI entrez gene - 117145     See in Manteia.
OMIM - 606388
RefSeq - NM_053055
RefSeq - XM_011509142
RefSeq Peptide - NP_444283
swissprot - E9PLJ7
swissprot - Q5T1C6
swissprot - F6XC58
Ensembl - ENSG00000159445
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 them4ENSDARG00000061621Danio rerio
 Them4ENSMUSG00000028145Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
THEM5 / Q8N1Q8 / thioesterase superfamily member 5ENSG0000019640735


Protein motifs (from Interpro)
Interpro ID Name
 IPR006683  Thioesterase domain
 IPR029069  HotDog domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006631 fatty acid metabolic process IEA
 biological_processGO:0006637 acyl-CoA metabolic process TAS
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0043491 protein kinase B signaling IMP
 biological_processGO:0051898 negative regulation of protein kinase B signaling TAS
 biological_processGO:1902108 regulation of mitochondrial membrane permeability involved in apoptotic process IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005743 mitochondrial inner membrane IEA
 cellular_componentGO:0005758 mitochondrial intermembrane space IEA
 cellular_componentGO:0005759 mitochondrial matrix TAS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0032587 ruffle membrane IEA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016290 palmitoyl-CoA hydrolase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0047617 acyl-CoA hydrolase activity TAS
 molecular_functionGO:0102991 myristoyl-CoA hydrolase activity IEA


Pathways (from Reactome)
Pathway description
PIP3 activates AKT signaling
Activation of AKT2
Negative regulation of the PI3K/AKT network
CD28 dependent PI3K/Akt signaling
VEGFR2 mediated vascular permeability
Mitochondrial Fatty Acid Beta-Oxidation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000142208 AKT1 / P31749 / AKT serine/threonine kinase 1  / reaction / complex
 ENSG00000105221 AKT2 / P31751 / AKT serine/threonine kinase 2  / complex
 ENSG00000159445 THEM4 / Q5T1C6 / thioesterase superfamily member 4  / complex






 

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