ENSMUSG00000028148


Mus musculus

Features
Gene ID: ENSMUSG00000028148
  
Biological name :Them5
  
Synonyms : Q9CQJ0 / Them5 / thioesterase superfamily member 5
  
Possible biological names infered from orthology : Q8N1Q8
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: F2.1
Gene start: 94342099
Gene end: 94347352
  
Corresponding Affymetrix probe sets: 10494016 (MoGene1.0st)   1429354_at (Mouse Genome 430 2.0 Array)   1431211_s_at (Mouse Genome 430 2.0 Array)   1453801_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000142808
Ensembl peptide - ENSMUSP00000029794
NCBI entrez gene - 66198     See in Manteia.
MGI - MGI:1913448
RefSeq - NM_025416
RefSeq Peptide - NP_079692
swissprot - A0A0G2JEK7
swissprot - Q9CQJ0
Ensembl - ENSMUSG00000028148
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 them4ENSDARG00000061621Danio rerio
 ENSGALG00000026039Gallus gallus
 THEM5ENSG00000196407Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Them4 / Q3UUI3 / Acyl-coenzyme A thioesterase THEM4 / Q5T1C6* / thioesterase superfamily member 4*ENSMUSG0000002814533


Protein motifs (from Interpro)
Interpro ID Name
 IPR006683  Thioesterase domain
 IPR029069  HotDog domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006631 fatty acid metabolic process IEA
 biological_processGO:0035336 long-chain fatty-acyl-CoA metabolic process IEA
 biological_processGO:0035965 cardiolipin acyl-chain remodeling IMP
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005759 mitochondrial matrix ISO
 molecular_functionGO:0016290 palmitoyl-CoA hydrolase activity ISO
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0102991 myristoyl-CoA hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Mitochondrial Fatty Acid Beta-Oxidation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001554 increased circulating free fatty acid level "higher than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
Show

Allelic Composition: Lrp227SH/Lrp227SH
Genetic Background: involves: A/J * C57BL/6N

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lrp227SH/Lrp227SH
Genetic Background: involves: A/J * C57BL/6N

 MP:0005282 decreased fatty acid level "less than normal non-circulating level of organic, monobasic acids derived from hydrocarbons; they are saturated and unsaturated" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Lrp227SH/Lrp227SH
Genetic Background: involves: A/J * C57BL/6N

 MP:0006035 abnormal mitochondrial morphology "anomalous structure of the mitochondria" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Lrp227SH/Lrp227SH
Genetic Background: involves: A/J * C57BL/6N

 MP:0010954 abnormal cellular respiration "anomaly in the enzymatic release of energy from organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration)" [GO:0045333]
Show

Allelic Composition: Lrp227SH/Lrp227SH
Genetic Background: involves: A/J * C57BL/6N

 MP:0010955 abnormal respiratory electron transport chain "anomaly in the process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient" [GO:0022904]
Show

Allelic Composition: Lrp227SH/Lrp227SH
Genetic Background: involves: A/J * C57BL/6N

 MP:0011630 increased mitochondria size "enlarged the cellular organelles responsible for energy production" [MGI:csmith]
Show

Allelic Composition: Lrp227SH/Lrp227SH
Genetic Background: involves: A/J * C57BL/6N

 MP:0011633 abnormal mitochondrial shape "any anomaly in the characteristic surface outline or contour of a mitochondria" [MGI:csmith]
Show

Allelic Composition: Lrp227SH/Lrp227SH
Genetic Background: involves: A/J * C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000028148 Them5 / Q9CQJ0 / thioesterase superfamily member 5 / Q8N1Q8*  / complex






 

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