ENSMUSG00000028539


Mus musculus

Features
Gene ID: ENSMUSG00000028539
  
Biological name :Artn
  
Synonyms : Artemin / Artn / Q9Z0L2
  
Possible biological names infered from orthology : Q5T4W7
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: D2.1
Gene start: 117926162
Gene end: 117929763
  
Corresponding Affymetrix probe sets: 10515558 (MoGene1.0st)   1432032_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000095526
Ensembl peptide - ENSMUSP00000064521
NCBI entrez gene - 11876     See in Manteia.
MGI - MGI:1333791
RefSeq - NM_009711
RefSeq - XM_011240419
RefSeq - NM_001284191
RefSeq - NM_001284192
RefSeq - NM_001284193
RefSeq - XM_006502690
RefSeq - XM_006502691
RefSeq - XM_006502692
RefSeq - XM_006502693
RefSeq - XM_006502694
RefSeq Peptide - NP_001271121
RefSeq Peptide - NP_001271122
RefSeq Peptide - NP_033841
RefSeq Peptide - NP_001271120
swissprot - Q9Z0L2
Ensembl - ENSMUSG00000028539
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 artnaENSDARG00000096252Danio rerio
 ARTNENSGALG00000032098Gallus gallus
 ARTNENSG00000117407Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nrtn / P97463 / Neurturin / Q99748*ENSMUSG0000003948129
Pspn / persephin / O60542*ENSMUSG0000000266424
Gdnf / P48540 / Mus musculus glial cell line derived neurotrophic factor (Gdnf), transcript variant 3, mRNA. / P39905* / glial cell derived neurotrophic factor*ENSMUSG0000002214423


Protein motifs (from Interpro)
Interpro ID Name
 IPR001839  Transforming growth factor-beta, C-terminal
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007166 cell surface receptor signaling pathway ISO
 biological_processGO:0007411 axon guidance IMP
 biological_processGO:0007422 peripheral nervous system development IMP
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0050930 induction of positive chemotaxis IDA
 biological_processGO:0061146 Peyer"s patch morphogenesis IMP
 biological_processGO:0097021 lymphocyte migration into lymphoid organs IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IDA
 molecular_functionGO:0005102 signaling receptor binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008083 growth factor activity IEA
 molecular_functionGO:0030116 glial cell-derived neurotrophic factor receptor binding ISO


Pathways (from Reactome)
Pathway description
RAF/MAP kinase cascade
RET signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001008 abnormal sympathetic ganglia morphology "malformed or absent groups of neuronal cell bodies of the autonomic nervous system" [J:18048]
Show

Allelic Composition: Gfra3tm1Jmi/Gfra3tm1Jmi
Genetic Background: involves: 129X1/SvJ * FVB/N

 MP:0001011 abnormal superior cervical ganglion morphology "malformation or absence of the group of neurons that is the largest of the sympathetic trunk; normally lies at the base of the skull and innervates the head and neck" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Gfra3tm1Jmi/Gfra3tm1Jmi
Genetic Background: involves: 129X1/SvJ * FVB/N

 MP:0001015 small superior cervical ganglion "reduced size of the group of neurons that is the largest of the ganglia of the sympathetic trunk; normally lies at the base of the skull and innervates the head and neck" [J:23882]
Show

Allelic Composition: Gfra3tm1Jmi/Gfra3tm1Jmi
Genetic Background: involves: 129X1/SvJ * FVB/N

 MP:0001025 abnormal sympathetic neuron morphology "malformation or anomalous development of any of the neurons of the part of the autonomic nervous system that innervates smooth muscle, cardiac muscle and glands and mediates the body s response to stressful situations" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Gfra3tm1Jmi/Gfra3tm1Jmi
Genetic Background: involves: 129X1/SvJ * FVB/N

 MP:0001046 abnormal enteric neuron morphology "malformed or absent neurons that innervate the esophagus, stomach, small and large bowel" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gfra3tm1Jmi/Gfra3tm1Jmi
Genetic Background: involves: 129X1/SvJ * FVB/N

 MP:0001344 blepharoptosis "ptosis, drooping eyelids " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:24414]
Show

Allelic Composition: Gfra3tm1Jmi/Gfra3tm1Jmi
Genetic Background: involves: 129X1/SvJ * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000002664 Pspn / persephin / O60542*  / reaction / complex
 ENSMUSG00000059923 Grb2 / Q60631 / Growth factor receptor-bound protein 2 / P62993*  / complex / reaction
 ENSMUSG00000019312 Grb7 / Q03160 / Growth factor receptor-bound protein 7 / Q14451*  / complex / reaction
 ENSMUSG00000020170 Frs2 / Q8C180 / Fibroblast growth factor receptor substrate 2 / Q8WU20*  / complex / reaction
 ENSMUSG00000025089 Gfra1 / P97785 / GDNF family receptor alpha-1 / P56159*  / complex / reaction
 ENSMUSG00000022144 Gdnf / P48540 / Mus musculus glial cell line derived neurotrophic factor (Gdnf), transcript variant 3, mRNA. / P39905* / glial cell derived neurotrophic factor*  / complex / reaction
 ENSMUSG00000022103 Gfra2 / O08842 / GDNF family receptor alpha-2 / O00451*  / complex / reaction
 ENSMUSG00000027316 Gfra4 / Q9JJT2 / GDNF family receptor alpha-4 / Q9GZZ7*  / complex / reaction
 ENSMUSG00000030110 Ret / P35546 / Proto-onco tyrosine-protein kinase receptor Ret Soluble RET kinase fragment Extracellular cell-membrane anchored RET cadherin 120 kDa fragment / P07949* / ret proto-oncogene*  / reaction / complex
 ENSMUSG00000039481 Nrtn / P97463 / Neurturin / Q99748*  / complex / reaction
 ENSMUSG00000024366 Gfra3 / O35118 / GDNF family receptor alpha-3 / O60609*  / complex / reaction
 ENSMUSG00000032462 Pik3cb / Q8BTI9 / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform / P42338* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta*  / complex
 ENSMUSG00000041417 P26450 / Pik3r1 / phosphoinositide-3-kinase regulatory subunit 1 / P27986*  / complex
 ENSMUSG00000027665 P42337 / Pik3ca / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform / P42336* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha*  / complex
 ENSMUSG00000016933 Plcg1 / Q62077 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 / P19174* / phospholipase C gamma 1*  / complex / reaction
 ENSMUSG00000042626 Shc1 / P98083 / SHC-transforming protein 1 / P29353* / SHC adaptor protein 1*  / reaction / complex
 ENSMUSG00000028539 Artn / Q9Z0L2 / Artemin / Q5T4W7*  / complex / reaction
 ENSMUSG00000041351 A2ALS5 / Rap1gap / Mus musculus Rap1 GTPase-activating protein (Rap1gap), transcript variant 5, mRNA. / P47736* / RAP1 GTPase activating protein*  / reaction / complex
 ENSMUSG00000043733 P35235 / Ptpn11 / Tyrosine-protein phosphatase non-receptor type 11 / Q06124* / protein tyrosine phosphatase, non-receptor type 11*  / reaction / complex
 ENSMUSG00000039936 O35904 / Pik3cd / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta / O00329*  / complex
 ENSMUSG00000031714 Gab1 / Q9QYY0 / GRB2-associated-binding protein 1 / Q13480*  / complex
 ENSMUSG00000027646 Src / P05480 / Neuronal proto-onco tyrosine-protein kinase Src / P12931* / SRC proto-oncogene, non-receptor tyrosine kinase*  / complex / reaction
 ENSMUSG00000024241 Sos1 / Q62245 / Son of sevenless homolog 1 / Q07889* / SOS Ras/Rac guanine nucleotide exchange factor 1*  / complex / reaction
 ENSMUSG00000004508 Gab2 / GAB4* / Q2WGN9* / Q9UQC2* / GRB2 associated binding protein 2* / GRB2 associated binding protein family member 4*  / complex
 ENSMUSG00000020176 Grb10 / Q60760 / Growth factor receptor-bound protein 10 / Q13322*  / reaction / complex






 

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