ENSMUSG00000027316


Mus musculus

Features
Gene ID: ENSMUSG00000027316
  
Biological name :Gfra4
  
Synonyms : GDNF family receptor alpha-4 / Gfra4 / Q9JJT2
  
Possible biological names infered from orthology : Q9GZZ7
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: F1
Gene start: 131039632
Gene end: 131043088
  
Corresponding Affymetrix probe sets: 10487787 (MoGene1.0st)   1450835_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000105869
Ensembl peptide - ENSMUSP00000105864
Ensembl peptide - ENSMUSP00000105868
Ensembl peptide - ENSMUSP00000028787
Ensembl peptide - ENSMUSP00000068357
Ensembl peptide - ENSMUSP00000105863
NCBI entrez gene - 14588     See in Manteia.
MGI - MGI:1341873
RefSeq - XM_017315629
RefSeq - NM_001136063
RefSeq - NM_001271001
RefSeq - NM_001271002
RefSeq - NM_020014
RefSeq Peptide - NP_001129535
RefSeq Peptide - NP_001257930
RefSeq Peptide - NP_001257931
RefSeq Peptide - NP_064398
swissprot - Q9JJT2
swissprot - A2AP45
Ensembl - ENSMUSG00000027316
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gfra4aENSDARG00000056651Danio rerio
 gfra4bENSDARG00000074582Danio rerio
 GFRA4ENSGALG00000036589Gallus gallus
 GFRA4ENSG00000125861Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gfra2 / O08842 / GDNF family receptor alpha-2 / O00451*ENSMUSG0000002210335
Gfra1 / P97785 / GDNF family receptor alpha-1 / P56159*ENSMUSG0000002508932
Gfra3 / O35118 / GDNF family receptor alpha-3 / O60609*ENSMUSG0000002436627


Protein motifs (from Interpro)
Interpro ID Name
 IPR003438  Glial cell line-derived neurotrophic factor receptor
 IPR016017  GDNF/GAS1
 IPR037193  GDNF receptor alpha


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway TAS
 biological_processGO:0030279 negative regulation of ossification IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031225 anchored component of membrane IEA
 molecular_functionGO:0015026 coreceptor activity TAS


Pathways (from Reactome)
Pathway description
RAF/MAP kinase cascade
RET signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002876 abnormal thyroid physiology "anomalous function of this endocrine gland that normally produces hormones that regulate the metabolic rate of the body " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Itga2tm1Ztr/Itga2tm1Ztr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0020039 increased bone ossification "increase in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [ORCID: orcid.org/0000-0003-4606-0597]
Show

Allelic Composition: Itga2tm1Ztr/Itga2tm1Ztr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0020080 increased bone mineralization "increase in the rate at which minerals are deposited into bone" [ORCID: orcid.org/0000-0003-4606-0597]
Show

Allelic Composition: Itga2tm1Ztr/Itga2tm1Ztr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000002664 Pspn / persephin / O60542*  / complex / reaction
 ENSMUSG00000059923 Grb2 / Q60631 / Growth factor receptor-bound protein 2 / P62993*  / complex / reaction
 ENSMUSG00000019312 Grb7 / Q03160 / Growth factor receptor-bound protein 7 / Q14451*  / complex / reaction
 ENSMUSG00000020170 Frs2 / Q8C180 / Fibroblast growth factor receptor substrate 2 / Q8WU20*  / complex / reaction
 ENSMUSG00000024366 Gfra3 / O35118 / GDNF family receptor alpha-3 / O60609*  / complex / reaction
 ENSMUSG00000032462 Pik3cb / Q8BTI9 / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform / P42338* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta*  / complex
 ENSMUSG00000030110 Ret / P35546 / Proto-onco tyrosine-protein kinase receptor Ret Soluble RET kinase fragment Extracellular cell-membrane anchored RET cadherin 120 kDa fragment / P07949* / ret proto-oncogene*  / reaction / complex
 ENSMUSG00000027665 P42337 / Pik3ca / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform / P42336* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha*  / complex
 ENSMUSG00000039481 Nrtn / P97463 / Neurturin / Q99748*  / reaction / complex
 ENSMUSG00000042626 Shc1 / P98083 / SHC-transforming protein 1 / P29353* / SHC adaptor protein 1*  / reaction / complex
 ENSMUSG00000025089 Gfra1 / P97785 / GDNF family receptor alpha-1 / P56159*  / reaction / complex
 ENSMUSG00000016933 Plcg1 / Q62077 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 / P19174* / phospholipase C gamma 1*  / complex / reaction
 ENSMUSG00000027316 Gfra4 / Q9JJT2 / GDNF family receptor alpha-4 / Q9GZZ7*  / complex / reaction
 ENSMUSG00000024241 Sos1 / Q62245 / Son of sevenless homolog 1 / Q07889* / SOS Ras/Rac guanine nucleotide exchange factor 1*  / reaction / complex
 ENSMUSG00000028539 Artn / Q9Z0L2 / Artemin / Q5T4W7*  / reaction / complex
 ENSMUSG00000041417 P26450 / Pik3r1 / phosphoinositide-3-kinase regulatory subunit 1 / P27986*  / complex
 ENSMUSG00000022103 Gfra2 / O08842 / GDNF family receptor alpha-2 / O00451*  / reaction / complex
 ENSMUSG00000004508 Gab2 / GAB4* / Q2WGN9* / Q9UQC2* / GRB2 associated binding protein 2* / GRB2 associated binding protein family member 4*  / complex
 ENSMUSG00000027646 Src / P05480 / Neuronal proto-onco tyrosine-protein kinase Src / P12931* / SRC proto-oncogene, non-receptor tyrosine kinase*  / reaction / complex
 ENSMUSG00000039936 O35904 / Pik3cd / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta / O00329*  / complex
 ENSMUSG00000022144 Gdnf / P48540 / Mus musculus glial cell line derived neurotrophic factor (Gdnf), transcript variant 3, mRNA. / P39905* / glial cell derived neurotrophic factor*  / reaction / complex
 ENSMUSG00000041351 A2ALS5 / Rap1gap / Mus musculus Rap1 GTPase-activating protein (Rap1gap), transcript variant 5, mRNA. / P47736* / RAP1 GTPase activating protein*  / reaction / complex
 ENSMUSG00000043733 P35235 / Ptpn11 / Tyrosine-protein phosphatase non-receptor type 11 / Q06124* / protein tyrosine phosphatase, non-receptor type 11*  / reaction / complex
 ENSMUSG00000031714 Gab1 / Q9QYY0 / GRB2-associated-binding protein 1 / Q13480*  / complex
 ENSMUSG00000020176 Grb10 / Q60760 / Growth factor receptor-bound protein 10 / Q13322*  / reaction / complex






 

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