ENSMUSG00000006386


Mus musculus

Features
Gene ID: ENSMUSG00000006386
  
Biological name :Tek
  
Synonyms : Q02858 / Tek / TEK receptor tyrosine kinase
  
Possible biological names infered from orthology : Q02763
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: C5
Gene start: 94739289
Gene end: 94874976
  
Corresponding Affymetrix probe sets: 10505954 (MoGene1.0st)   1418788_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000071162
Ensembl peptide - ENSMUSP00000073595
Ensembl peptide - ENSMUSP00000099862
NCBI entrez gene - 21687     See in Manteia.
MGI - MGI:98664
RefSeq - XM_006502930
RefSeq - NM_001290549
RefSeq - NM_001290551
RefSeq - NM_013690
RefSeq Peptide - NP_001277478
RefSeq Peptide - NP_001277480
RefSeq Peptide - NP_038718
swissprot - Q02858
swissprot - Q80YS4
swissprot - B1AWS8
Ensembl - ENSMUSG00000006386
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tekENSDARG00000028663Danio rerio
 TEKENSGALG00000001840Gallus gallus
 TEKENSG00000120156Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tie1 / Q06806 / tyrosine kinase with immunoglobulin-like and EGF-like domains 1 / P35590*ENSMUSG0000003319147
Axl / Q00993 / AXL receptor tyrosine kinase / P30530*ENSMUSG0000000260218
Mertk / Q60805 / Tyrosine-protein kinase Mer / Q12866* / MER proto-oncogene, tyrosine kinase*ENSMUSG0000001436117
Tyro3 / P55144 / TYRO3 protein tyrosine kinase 3 / Q06418* / TYRO3 protein tyrosine kinase*ENSMUSG0000002729817
Met / MET proto-oncogene, receptor tyrosine kinase / P08581*ENSMUSG0000000937616
Mst1r / Q62190 / macrophage stimulating 1 receptor (c-met-related tyrosine kinase) / Q04912* / macrophage stimulating 1 receptor*ENSMUSG0000003258416
Ryk / Q01887 / Tyrosine-protein kinase RYK / receptor-like tyrosine kinase*ENSMUSG0000003254711


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000742  EGF-like domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR003961  Fibronectin type III
 IPR007110  Immunoglobulin-like domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR013032  EGF-like, conserved site
 IPR013111  EGF-like domain, extracellular
 IPR013783  Immunoglobulin-like fold
 IPR017441  Protein kinase, ATP binding site
 IPR018941  Tyrosine-protein kinase, receptor Tie-2, Ig-like domain 1, N-terminal
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR036116  Fibronectin type III superfamily
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis TAS
 biological_processGO:0001569 branching involved in blood vessel morphogenesis TAS
 biological_processGO:0001570 vasculogenesis IMP
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0001934 positive regulation of protein phosphorylation ISS
 biological_processGO:0001935 endothelial cell proliferation IMP
 biological_processGO:0001936 regulation of endothelial cell proliferation TAS
 biological_processGO:0001958 endochondral ossification IEA
 biological_processGO:0002040 sprouting angiogenesis ISO
 biological_processGO:0002741 positive regulation of cytokine secretion involved in immune response IDA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007160 cell-matrix adhesion IMP
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway ISS
 biological_processGO:0007507 heart development IMP
 biological_processGO:0010033 response to organic substance IEA
 biological_processGO:0010595 positive regulation of endothelial cell migration ISS
 biological_processGO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling ISS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016525 negative regulation of angiogenesis ISO
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IDA
 biological_processGO:0030097 hemopoiesis IMP
 biological_processGO:0030334 regulation of cell migration IMP
 biological_processGO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway TAS
 biological_processGO:0032526 response to retinoic acid IDA
 biological_processGO:0032878 regulation of establishment or maintenance of cell polarity ISS
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IGI
 biological_processGO:0034446 substrate adhesion-dependent cell spreading ISS
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0042307 positive regulation of protein import into nucleus IDA
 biological_processGO:0043066 negative regulation of apoptotic process IGI
 biological_processGO:0043434 response to peptide hormone IEA
 biological_processGO:0043552 positive regulation of phosphatidylinositol 3-kinase activity ISS
 biological_processGO:0043627 response to estrogen IEA
 biological_processGO:0045765 regulation of angiogenesis IMP
 biological_processGO:0045766 positive regulation of angiogenesis ISS
 biological_processGO:0045785 positive regulation of cell adhesion IMP
 biological_processGO:0046777 protein autophosphorylation ISS
 biological_processGO:0048014 Tie signaling pathway ISS
 biological_processGO:0051259 protein complex oligomerization ISO
 biological_processGO:0051591 response to cAMP IEA
 biological_processGO:0051894 positive regulation of focal adhesion assembly ISO
 biological_processGO:0051897 positive regulation of protein kinase B signaling ISS
 biological_processGO:0060347 heart trabecula formation IMP
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade ISS
 biological_processGO:0072012 glomerulus vasculature development IEA
 biological_processGO:0098609 cell-cell adhesion IMP
 biological_processGO:1901222 regulation of NIK/NF-kappaB signaling IGI
 biological_processGO:1902533 positive regulation of intracellular signal transduction ISS
 biological_processGO:2000251 positive regulation of actin cytoskeleton reorganization ISO
 biological_processGO:2000352 negative regulation of endothelial cell apoptotic process IMP
 cellular_componentGO:0001725 stress fiber ISO
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005815 microtubule organizing center ISO
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005884 actin filament ISO
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane ISO
 cellular_componentGO:0005902 microvillus ISO
 cellular_componentGO:0005911 cell-cell junction ISO
 cellular_componentGO:0005925 focal adhesion IEA
 cellular_componentGO:0009925 basal plasma membrane ISO
 cellular_componentGO:0009986 cell surface ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane ISM
 cellular_componentGO:0016323 basolateral plasma membrane ISO
 cellular_componentGO:0016324 apical plasma membrane ISO
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0045121 membrane raft ISO
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity ISO
 molecular_functionGO:0004714 transmembrane receptor protein tyrosine kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019838 growth factor binding IEA


Pathways (from Reactome)
Pathway description
Tie2 Signaling
RAF/MAP kinase cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000259 abnormal vascular development "malformation or aberrant differentiation of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17509]
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Allelic Composition: Icostm1Flv/Icostm1Flv,Tg(Cd4-Maf)6666Glm/0
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Tektm1Dmt/Tek+,Tie1tm1Jpa/Tie1tm1Jpa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0000260 abnormal angiogenesis "aberrant process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Grhl3ct-J/Grhl3ct-J,mct1C57BL/6J/mct1C57BL/6J
Genetic Background: involves: BALB/cByJ * STOCK ct/J

Allelic Composition: Tektm1Sato/Tektm1Sato
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0000263 absent organized vascular network "formation of vasculature, but failure to differentiate into stereotypic organized pattern" [J:53370]
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Allelic Composition: Tektm1Dmt/Tektm1Dmt,Tie1tm1Jpa/Tie1tm1Jpa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0000264 failure of vascular branching "failure of vasculature to form divisions (offshoots)" [J:53370]
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Allelic Composition: Lipctm1Unc/Lipctm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Tektm1Dmt/Tektm1Dmt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Tektm1Sato/Tektm1Sato
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
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Allelic Composition: Lipctm1Unc/Lipctm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Tektm1Dmt/Tektm1Dmt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Tektm1Sato/Tektm1Sato
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Tektm1Dmt/Tektm1Dmt,Tie1tm1Jpa/Tie1tm1Jpa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Tektm1Dmt/Tek+,Tie1tm1Jpa/Tie1tm1Jpa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0000291 enlarged pericardium "extended fibroserous membrane covering the heart and beginning of the great vessels" [J:29971]
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Allelic Composition: Tektm1Dmt/Tektm1Dmt,Tie1tm1Jpa/Tie1tm1Jpa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Tektm1Dmt/Tek+,Tie1tm1Jpa/Tie1tm1Jpa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0000292 distended pericardial sacs "stretched outer parietal layer of the pericardium" [J:25248]
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Allelic Composition: F7tm1Pec/F7tm1Pec,Tfpitm1Gjb/Tfpitm1Gjb
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0000293 absent myocardial trabeculae "absence of the supporting bundles of muscular fibers lining the walls of the heart" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lipctm1Unc/Lipctm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Tektm1Dmt/Tektm1Dmt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0000296 absent ventricular trabeculae "missing supporting bundles of muscular fibers lining the walls of the ventricles of the heart" [J:45302]
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Allelic Composition: Tektm1Sato/Tektm1Sato
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0001312 abnormal cornea morphology "malformation or absence of the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Angpt1tm1.1Seq/Angpt1tm1.1Seq,Angpt2tm1c(KOMP)Seq/Angpt2tm1c(KOMP)Seq,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/?,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * C57BL/6NCr

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tie1tm1Sato/Tie1tm1Sato
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Tektm1Dmt/Tektm1Dmt,Tie1tm1Jpa/Tie1tm1Jpa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0001688 abnormal somite development "anomalous formation of any of the paired, metamerically arranged cell masses formed in the embryonic paraxial mesoderm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tektm1Dmt/Tektm1Dmt,Tie1tm1Jpa/Tie1tm1Jpa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Tektm1Dmt/Tektm1Dmt,Tie1tm1Jpa/Tie1tm1Jpa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0001718 abnormal yolk sac "malformed extraembryonic tissue which contributes to hematopoietic circulation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:12623]
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Allelic Composition: F7tm1Pec/F7tm1Pec,Tfpitm1Gjb/Tfpitm1Gjb
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001719 absent vitelline blood vessels "missing vasculature of the yolk sac" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:62571, J:12623]
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Allelic Composition: F7tm1Pec/F7tm1Pec,Tfpitm1Gjb/Tfpitm1Gjb
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
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Allelic Composition: Icostm1Flv/Icostm1Flv,Tg(Cd4-Maf)6666Glm/0
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Tektm1Dmt/Tek+,Tie1tm1Jpa/Tie1tm1Jpa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: F7tm1Pec/F7tm1Pec,Tfpitm1Gjb/Tfpitm1Gjb
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Tektm1Dmt/Tek+,Tie1tm1Jpa/Tie1tm1Jpa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0001915 intracranial hemorrhage "bleeding within the skull, including hemorrhage into the brain and within the cranial epidural, subdural, and subarachnoid spaces" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Tektm1Dmt/Tektm1Dmt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0002123 abnormal hematopoiesis "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lipctm1Unc/Lipctm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Tektm1Dmt/Tektm1Dmt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sox10tm1.1Sout/Sox10tm1.1Sout
Genetic Background: involves: C57BL/6N

 MP:0002189 abnormal myocardial trabeculae morphology "malformation of the supporting bundles of muscular fibers lining the walls of the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tektm1Dmt/Tektm1Dmt,Tie1tm1Jpa/Tie1tm1Jpa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0002925 abnormal cardiovascular development "aberrant formation or incomplete differentiation of the cardiovascular system" [RGD:Rat Genome Database submission]
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Allelic Composition: Tektm1Dmt/Tek+,Tie1tm1Jpa/Tie1tm1Jpa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0003227 abnormal vascular branching morphogenesis "increase, decrease or anomaly in the process by which new vessels sprout off pre-existing vessels" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93157]
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Allelic Composition: Tektm1Sato/Tektm1Sato
Genetic Background: either: (involves: 129S1/Sv * 129T2/SvEmsJ) or (involves: 129S1/Sv * C57BL/6J)

 MP:0003229 abnormal vitelline vasculature "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]
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Allelic Composition: Lipctm1Unc/Lipctm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Tektm1Sato/Tektm1Sato
Genetic Background: either: (involves: 129S1/Sv * 129T2/SvEmsJ) or (involves: 129S1/Sv * C57BL/6J)

Allelic Composition: Tektm1Dmt/Tektm1Dmt,Tie1tm1Jpa/Tie1tm1Jpa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0003232 abnormal forebrain development "anomaly in the formation or patterning of the anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [J:93081, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Tektm1Dmt/Tektm1Dmt,Tie1tm1Jpa/Tie1tm1Jpa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0003719 abnormal pericyte morphology "malformation in the connective tissue cells that occurs around capillaries or other small blood vessels " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Tektm1Dmt/Tektm1Dmt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tektm1Sato/Tektm1Sato
Genetic Background: either: (involves: 129S1/Sv * 129T2/SvEmsJ) or (involves: 129S1/Sv * C57BL/6J)

 MP:0004076 abnormal vitelline vascular remodelling "anomaly in the conversion of the primary (honeycomb-like) vascular plexus of the yolk sac into a mature vascular network" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: F7tm1Pec/F7tm1Pec,Tfpitm1Gjb/Tfpitm1Gjb
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Tektm1Dmt/Tektm1Dmt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Tektm1Dmt/Tektm1Dmt,Tie1tm1Jpa/Tie1tm1Jpa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0004787 abnormal dorsal aorta morphology "any structural anomaly of the paired arterial structures of the embryo that supplies each developing somite via efferent segmental arteries; the dorsal aortae articulate with the umbilical arteries, which return mixed blood to the villi of the chorion for reoxygenation" [ISBN:0-914294-08-3 "Gray s Anatomy"]
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Allelic Composition: F7tm1Pec/F7tm1Pec,Tfpitm1Gjb/Tfpitm1Gjb
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005193 abnormal anterior eye segment morphology "anomalous structure of any of the parts of the eye that lie in front of, or ventral to, the lens (inclusive) " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tektm1.1Vlcg/Tektm1.1Vlcg,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/?,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * C57BL/6NCr

 MP:0005602 decreased angiogenesis "reduced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission]
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Allelic Composition: Tektm1Dmt/Tektm1Dmt,Tie1tm1Jpa/Tie1tm1Jpa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0006055 abnormal vascular endothelial cell morphology "malformation in the cells that line the vasculature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Tektm1Dmt/Tektm1Dmt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Tektm1Sato/Tektm1Sato
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0006138 congestive heart failure "the heart is unable to adequately pump blood throughout the body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Tektm1Dmt/Tektm1Dmt,Tie1tm1Jpa/Tie1tm1Jpa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Tektm1Dmt/Tek+,Tie1tm1Jpa/Tie1tm1Jpa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0009274 buphthalmos "abnormal enlargement of the eye that is usually congenital and attended by symptoms of glaucoma" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Tektm1.1Vlcg/Tektm1.1Vlcg,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/?,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * C57BL/6NCr

 MP:0009698 heart hemorrhage "bleeding into the heart" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Tektm1Dmt/Tek+,Tie1tm1Jpa/Tie1tm1Jpa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Lipctm1Unc/Lipctm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Tektm1Dmt/Tektm1Dmt
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Tektm1Sato/Tektm1Sato
Genetic Background: either: (involves: 129S1/Sv * 129T2/SvEmsJ) or (involves: 129S1/Sv * C57BL/6J)

Allelic Composition: Tektm1Dmt/Tektm1Dmt,Tie1tm1Jpa/Tie1tm1Jpa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Tektm1Dmt/Tek+,Tie1tm1Jpa/Tie1tm1Jpa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Tektm1.1(icre/Esr1*)Hrr/Tektm1.1(icre/Esr1*)Hrr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011960 abnormal eye anterior chamber depth "anomaly in the distance between the iris and the cornea at the center plane (maximum distance) of the anterior chamber, compared to controls" [MGI:csmith]
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Allelic Composition: Tektm1.1Vlcg/Tektm1.1Vlcg,Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/?,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129 * C57BL/6NCr

 MP:0013241 embryo tissue necrosis "morphological changes resulting from pathological death of some or all embryo tissue; usually due to irreversible damage" [MGI:csmith]
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Allelic Composition: Tektm1Sato/Tektm1Sato
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Tektm1Dmt/Tektm1Dmt,Tie1tm1Jpa/Tie1tm1Jpa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000059923 Grb2 / Q60631 / Growth factor receptor-bound protein 2 / P62993*  / reaction / complex
 ENSMUSG00000019312 Grb7 / Q03160 / Growth factor receptor-bound protein 7 / Q14451*  / complex / reaction
 ENSMUSG00000022309 Angpt1 / O08538 / Angiopoietin-1 / Q15389*  / complex / reaction
 ENSMUSG00000031465 Angpt2 / O35608 / Angiopoietin-2 / O15123*  / reaction / complex
 ENSMUSG00000027460 Angpt4 / Q9WVH6 / Angiopoietin-4 / Q9Y264*  / reaction / complex
 ENSMUSG00000024241 Sos1 / Q62245 / Son of sevenless homolog 1 / Q07889* / SOS Ras/Rac guanine nucleotide exchange factor 1*  / reaction / complex
 ENSMUSG00000032462 Pik3cb / Q8BTI9 / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform / P42338* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta*  / complex / reaction
 ENSMUSG00000043733 P35235 / Ptpn11 / Tyrosine-protein phosphatase non-receptor type 11 / Q06124* / protein tyrosine phosphatase, non-receptor type 11*  / complex / reaction
 ENSMUSG00000041417 P26450 / Pik3r1 / phosphoinositide-3-kinase regulatory subunit 1 / P27986*  / complex / reaction
 ENSMUSG00000026888 Grb14 / Q9JLM9 / Growth factor receptor-bound protein 14 / Q14449*  / reaction / complex
 ENSMUSG00000006386 Tek / Q02858 / TEK receptor tyrosine kinase / Q02763*  / complex / reaction
 ENSMUSG00000042626 Shc1 / P98083 / SHC-transforming protein 1 / P29353* / SHC adaptor protein 1*  / complex / reaction
 ENSMUSG00000022102 Dok2 / O70469 / Docking protein 2 / O60496*  / reaction / complex
 ENSMUSG00000031834 O08908 / Pik3r2 / Phosphatidylinositol 3-kinase regulatory subunit beta / O00459* / AC007192.1* / phosphoinositide-3-kinase regulatory subunit 2*  / reaction / complex
 ENSMUSG00000072115 Ang / P21570 / Angiogenin / P03950*  / complex
 ENSMUSG00000027665 P42337 / Pik3ca / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform / P42336* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha*  / complex / reaction






 

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