ENSMUSG00000072115


Mus musculus

Features
Gene ID: ENSMUSG00000072115
  
Biological name :Ang
  
Synonyms : Ang / Angiogenin / P21570
  
Possible biological names infered from orthology : P03950
  
Species: Mus musculus
  
Chr. number: 14
Strand: 1
Band: C1
Gene start: 51091150
Gene end: 51102009
  
Corresponding Affymetrix probe sets: 1438936_s_at (Mouse Genome 430 2.0 Array)   1438937_x_at (Mouse Genome 430 2.0 Array)   1450717_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000067434
Ensembl peptide - ENSMUSP00000132084
NCBI entrez gene - 11727     See in Manteia.
MGI - MGI:88022
RefSeq - NM_007447
RefSeq - NM_001161731
RefSeq Peptide - NP_001155203
RefSeq Peptide - NP_031473
swissprot - P21570
swissprot - Q3TBG7
Ensembl - ENSMUSG00000072115
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rnasel2ENSDARG00000043196Danio rerio
 rnasel3ENSDARG00000036171Danio rerio
 ANGENSG00000214274Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ang2 / Q64438 / Angiogenin-2 / ANG* / P03950* / angiogenin*ENSMUSG0000004789478
Ang4 / Q3TMQ6 / Angiogenin-4 / ANG* / P03950* / angiogenin*ENSMUSG0000006061572
Ang5 / angiogenin, ribonuclease A family, member 5 / ANG* / P03950* / angiogenin*ENSMUSG0000005396169
Ang6 / angiogenin, ribonuclease A family, member 6 / ANG* / P03950* / angiogenin*ENSMUSG0000007259863
Rnase4 / ribonuclease, RNase A family 4 / P34096* / ribonuclease A family member 4*ENSMUSG0000002187640
Rnase1 / ribonuclease, RNase A family, 1 (pancreatic) / P07998* / ribonuclease A family member 1, pancreatic*ENSMUSG0000003589634


Protein motifs (from Interpro)
Interpro ID Name
 IPR001427  Pancreatic ribonuclease
 IPR023411  Ribonuclease A, active site
 IPR023412  Ribonuclease A-domain
 IPR036816  Ribonuclease A-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis ISO
 biological_processGO:0001666 response to hypoxia ISS
 biological_processGO:0001938 positive regulation of endothelial cell proliferation ISS
 biological_processGO:0006651 diacylglycerol biosynthetic process ISO
 biological_processGO:0007202 activation of phospholipase C activity ISS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007417 central nervous system development NAS
 biological_processGO:0009303 rRNA transcription ISO
 biological_processGO:0009725 response to hormone ISO
 biological_processGO:0016477 cell migration ISO
 biological_processGO:0017148 negative regulation of translation IEA
 biological_processGO:0030041 actin filament polymerization ISS
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0032148 activation of protein kinase B activity ISO
 biological_processGO:0032431 activation of phospholipase A2 activity ISO
 biological_processGO:0042327 positive regulation of phosphorylation ISO
 biological_processGO:0048662 negative regulation of smooth muscle cell proliferation ISS
 biological_processGO:0050714 positive regulation of protein secretion ISS
 biological_processGO:0090305 nucleic acid phosphodiester bond hydrolysis IEA
 biological_processGO:0090501 RNA phosphodiester bond hydrolysis IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005605 basal lamina ISS
 cellular_componentGO:0005615 extracellular space ISS
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005730 nucleolus ISS
 cellular_componentGO:0030426 growth cone IDA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0032311 angiogenin-PRI complex ISS
 cellular_componentGO:0043025 neuronal cell body IDA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003723 RNA binding IC
 molecular_functionGO:0003779 actin binding ISS
 molecular_functionGO:0004518 nuclease activity IEA
 molecular_functionGO:0004519 endonuclease activity IBA
 molecular_functionGO:0004540 ribonuclease activity ISS
 molecular_functionGO:0005102 signaling receptor binding ISS
 molecular_functionGO:0005507 copper ion binding ISS
 molecular_functionGO:0008201 heparin binding ISS
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0042277 peptide binding ISO
 molecular_functionGO:0042803 protein homodimerization activity ISS


Pathways (from Reactome)
Pathway description
Adherens junctions interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000006386 Tek / Q02858 / TEK receptor tyrosine kinase / Q02763*  / complex
 ENSMUSG00000072115 Ang / P21570 / Angiogenin / P03950*  / complex






 

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