ENSGALG00000001840


Gallus gallus

Features
Gene ID: ENSGALG00000001840
  
Biological name :TEK
  
Synonyms : TEK / TEK receptor tyrosine kinase
  
Possible biological names infered from orthology : Q02763 / Q02858
  
Species: Gallus gallus
  
Chr. number: Z
Strand: 1
Band:
Gene start: 68562096
Gene end: 68597536
  
Corresponding Affymetrix probe sets: GgaAffx.1208.3.S1_s_at (Chicken Array)   GgaAffx.1208.4.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000002841
Ensembl peptide - ENSGALP00000048677
NCBI entrez gene - 427368     See in Manteia.
RefSeq - XM_004949580
swissprot - A0A1D5P7I7
swissprot - F1NFQ9
Ensembl - ENSGALG00000001840
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tekENSDARG00000028663Danio rerio
 TEKENSG00000120156Homo sapiens
 TekENSMUSG00000006386Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TIE1 / tyrosine kinase with immunoglobulin like and EGF like domains 1 / P35590* / Q06806*ENSGALG0000000995747
MERTK / tyrosine-protein kinase Mer precursor / Q12866* / Q60805* / Tyrosine-protein kinase Mer * / MER proto-oncogene, tyrosine kinase*ENSGALG0000000825719
MST1R / macrophage-stimulating protein receptor precursor / Q04912* / Q62190* / macrophage stimulating 1 receptor* / macrophage stimulating 1 receptor (c-met-related tyrosine kinase)*ENSGALG0000000310316
TYRO3 / tyrosine-protein kinase receptor TYRO3 precursor / Q06418* / P55144* / TYRO3 protein tyrosine kinase* / TYRO3 protein tyrosine kinase 3*ENSGALG0000000863116
MET / hepatocyte growth factor receptor precursor / P08581* / MET proto-oncogene, receptor tyrosine kinase*ENSGALG0000003688315
RYK / receptor-like tyrosine kinase / Q01887* / Tyrosine-protein kinase RYK *ENSGALG0000000648811


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000742  EGF-like domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR003961  Fibronectin type III
 IPR007110  Immunoglobulin-like domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR013032  EGF-like, conserved site
 IPR013783  Immunoglobulin-like fold
 IPR017441  Protein kinase, ATP binding site
 IPR018941  Tyrosine-protein kinase, receptor Tie-2, Ig-like domain 1, N-terminal
 IPR020635  Tyrosine-protein kinase, catalytic domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0002040 sprouting angiogenesis IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA
 biological_processGO:0010595 positive regulation of endothelial cell migration IEA
 biological_processGO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016525 negative regulation of angiogenesis IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0032878 regulation of establishment or maintenance of cell polarity IEA
 biological_processGO:0034446 substrate adhesion-dependent cell spreading IEA
 biological_processGO:0043552 positive regulation of phosphatidylinositol 3-kinase activity IEA
 biological_processGO:0045766 positive regulation of angiogenesis IEA
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:0048014 Tie signaling pathway IEA
 biological_processGO:0051259 protein complex oligomerization IEA
 biological_processGO:0051894 positive regulation of focal adhesion assembly IEA
 biological_processGO:0051897 positive regulation of protein kinase B signaling IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:1902533 positive regulation of intracellular signal transduction IEA
 biological_processGO:2000251 positive regulation of actin cytoskeleton reorganization IEA
 cellular_componentGO:0001725 stress fiber IEA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005884 actin filament IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0005902 microvillus IEA
 cellular_componentGO:0005911 cell-cell junction IEA
 cellular_componentGO:0009925 basal plasma membrane IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0045121 membrane raft IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004714 transmembrane receptor protein tyrosine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
Tie2 Signaling
RAF/MAP kinase cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000036500 GRB7 / growth factor receptor bound protein 7 / Q03160* / Q14451*  / complex / reaction
 ENSGALG00000040755 ANGPT4 / angiopoietin 4 / Q9WVH6* / Q9Y264*  / complex / reaction
 ENSGALG00000001840 TEK / TEK receptor tyrosine kinase / Q02763* / Q02858*  / reaction / complex
 ENSGALG00000039450 SOS1 / SOS Ras/Rac guanine nucleotide exchange factor 1 / Q07889* / Q62245* / Son of sevenless homolog 1 *  / reaction / complex
 ENSGALG00000003428 O00459* / O08908* / PIK3R2* / AC007192.1* / phosphoinositide-3-kinase regulatory subunit 2* / Phosphatidylinositol 3-kinase regulatory subunit beta *  / complex / reaction
 ENSGALG00000008016 GRB2 / growth factor receptor-bound protein 2 / P62993* / Q60631*  / complex / reaction
 ENSGALG00000014786 PIK3R1 / phosphoinositide-3-kinase regulatory subunit 1 / P26450* / P27986*  / reaction / complex
 ENSGALG00000005505 PIK3CB / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta / P42338* / Q8BTI9* / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform *  / reaction / complex
 ENSGALG00000020703 GRB14 / growth factor receptor bound protein 14 / Q14449* / Q9JLM9*  / complex / reaction
 ENSGALG00000008934 PIK3CA / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha / P42336* / P42337* / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform *  / complex / reaction
 ENSGALG00000004821 PTPN11 / Q90687 / Tyrosine-protein phosphatase non-receptor type 11 / P35235* / Q06124* / protein tyrosine phosphatase, non-receptor type 11*  / complex / reaction
 ENSGALG00000029983 ANGPT1 / angiopoietin 1 / O08538* / Q15389*  / reaction / complex
 ENSGALG00000039775 SHC1 / SHC adaptor protein 1 / P29353* / P98083* / SHC-transforming protein 1 *  / complex / reaction






 

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