ENSGALG00000020703


Gallus gallus

Features
Gene ID: ENSGALG00000020703
  
Biological name :GRB14
  
Synonyms : GRB14 / growth factor receptor bound protein 14
  
Possible biological names infered from orthology : Q14449 / Q9JLM9
  
Species: Gallus gallus
  
Chr. number: 7
Strand: 1
Band:
Gene start: 20231963
Gene end: 20298979
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSGALP00000032500
Ensembl peptide - ENSGALP00000052386
Ensembl peptide - ENSGALP00000043709
NCBI entrez gene - 424183     See in Manteia.
RefSeq - XM_015289727
RefSeq - XM_015289728
RefSeq - XM_015289729
RefSeq - XM_015289730
swissprot - A0A1D5NTQ2
swissprot - F1P2E8
swissprot - A0A1D5PHV5
Ensembl - ENSGALG00000020703
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 GRB14ENSDARG00000068280Danio rerio
 GRB14ENSG00000115290Homo sapiens
 Grb14ENSMUSG00000026888Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GRB10 / growth factor receptor bound protein 10 / Q13322* / Q60760*ENSGALG0000001310055
GRB7 / growth factor receptor bound protein 7 / Q03160* / Q14451*ENSGALG0000003650047
APBB1IP / amyloid beta precursor protein binding family B member 1 interacting protein / Q7Z5R6* / Q8R5A3* / amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein*ENSGALG0000000757923
RAPH1* / Q70E73* / Ras association (RalGDS/AF-6) and pleckstrin homology domains 1*ENSGALG0000003168813


Protein motifs (from Interpro)
Interpro ID Name
 IPR000159  Ras-associating (RA) domain
 IPR000980  SH2 domain
 IPR001849  Pleckstrin homology domain
 IPR011993  PH-like domain superfamily
 IPR015042  BPS (Between PH and SH2) domain
 IPR029071  Ubiquitin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0009967 positive regulation of signal transduction IEA
 biological_processGO:0046627 negative regulation of insulin receptor signaling pathway IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0005070 SH3/SH2 adaptor activity IEA
 molecular_functionGO:0030971 receptor tyrosine kinase binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA


Pathways (from Reactome)
Pathway description
Tie2 Signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000001840 TEK / TEK receptor tyrosine kinase / Q02763* / Q02858*  / complex / reaction
 ENSGALG00000029983 ANGPT1 / angiopoietin 1 / O08538* / Q15389*  / complex / reaction






 

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