ENSG00000115290


Homo sapiens

Features
Gene ID: ENSG00000115290
  
Biological name :GRB14
  
Synonyms : GRB14 / growth factor receptor bound protein 14 / Q14449
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: -1
Band: q24.3
Gene start: 164492812
Gene end: 164621848
  
Corresponding Affymetrix probe sets: 206204_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000263915
Ensembl peptide - ENSP00000416786
Ensembl peptide - ENSP00000401702
NCBI entrez gene - 2888     See in Manteia.
OMIM - 601524
RefSeq - XM_017003899
RefSeq - NM_001303422
RefSeq - NM_004490
RefSeq Peptide - NP_001290351
RefSeq Peptide - NP_004481
swissprot - C9JLT6
swissprot - C9JD37
swissprot - Q14449
Ensembl - ENSG00000115290
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 GRB14ENSDARG00000068280Danio rerio
 GRB14ENSGALG00000020703Gallus gallus
 Grb14ENSMUSG00000026888Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GRB10 / Q13322 / growth factor receptor bound protein 10ENSG0000010607055
GRB7 / Q14451 / growth factor receptor bound protein 7ENSG0000014173847
RAPH1 / Q70E73 / Ras association (RalGDS/AF-6) and pleckstrin homology domains 1ENSG0000017316626
Q7Z5R6 / APBB1IP / amyloid beta precursor protein binding family B member 1 interacting proteinENSG0000007742025


Protein motifs (from Interpro)
Interpro ID Name
 IPR000159  Ras-associating (RA) domain
 IPR000980  SH2 domain
 IPR001849  Pleckstrin homology domain
 IPR011993  PH-like domain superfamily
 IPR015042  BPS (Between PH and SH2) domain
 IPR029071  Ubiquitin-like domain superfamily
 IPR035034  Grb14, SH2 domain
 IPR035035  Growth factor receptor-bound protein 14
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0009967 positive regulation of signal transduction IEA
 biological_processGO:0046627 negative regulation of insulin receptor signaling pathway IMP
 biological_processGO:0050900 leukocyte migration TAS
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0010008 endosome membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 molecular_functionGO:0005070 SH3/SH2 adaptor activity IEA
 molecular_functionGO:0030971 receptor tyrosine kinase binding IPI
 molecular_functionGO:0042802 identical protein binding IMP
 molecular_functionGO:0042803 protein homodimerization activity IMP


Pathways (from Reactome)
Pathway description
Tie2 Signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000154188 ANGPT1 / Q15389 / angiopoietin 1  / reaction / complex
 ENSG00000120156 TEK / Q02763 / TEK receptor tyrosine kinase  / reaction / complex






 

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