ENSG00000154188


Homo sapiens

Features
Gene ID: ENSG00000154188
  
Biological name :ANGPT1
  
Synonyms : angiopoietin 1 / ANGPT1 / Q15389
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: -1
Band: q23.1
Gene start: 107249482
Gene end: 107498055
  
Corresponding Affymetrix probe sets: 1552939_at (Human Genome U133 Plus 2.0 Array)   205608_s_at (Human Genome U133 Plus 2.0 Array)   205609_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000297450
Ensembl peptide - ENSP00000430750
Ensembl peptide - ENSP00000429349
Ensembl peptide - ENSP00000428908
Ensembl peptide - ENSP00000428340
NCBI entrez gene - 284     See in Manteia.
OMIM - 601667
RefSeq - NM_001146
RefSeq - NM_001199859
RefSeq - NM_001314051
RefSeq Peptide - NP_001186788
RefSeq Peptide - NP_001300980
RefSeq Peptide - NP_001137
swissprot - Q15389
swissprot - E5RFF4
swissprot - B4DTQ9
swissprot - E7ERK4
Ensembl - ENSG00000154188
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 angpt1ENSDARG00000030364Danio rerio
 ANGPT1ENSGALG00000029983Gallus gallus
 Angpt1ENSMUSG00000022309Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ANGPT2 / O15123 / angiopoietin 2ENSG0000009187959
ANGPT4 / Q9Y264 / angiopoietin 4ENSG0000010128045
O95841 / ANGPTL1 / angiopoietin like 1ENSG0000011619427
Q8NI99 / ANGPTL6 / angiopoietin like 6ENSG0000013081225
Q9UKU9 / ANGPTL2 / angiopoietin like 2ENSG0000013685925
FGL2 / Q14314 / fibrinogen like 2ENSG0000012795124
O43827 / ANGPTL7 / angiopoietin like 7ENSG0000017181924
FIBCD1 / Q8N539 / fibrinogen C domain containing 1ENSG0000013072021
FCN2 / Q15485 / ficolin 2ENSG0000016033920
FCN1 / O00602 / ficolin 1ENSG0000008526520
MFAP4 / P55083 / microfibril associated protein 4ENSG0000016648219
FCN3 / O75636 / ficolin 3ENSG0000014274818


Protein motifs (from Interpro)
Interpro ID Name
 IPR002181  Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
 IPR014715  Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 2
 IPR014716  Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
 IPR020837  Fibrinogen, conserved site
 IPR028843  Angiopoietin-1
 IPR036056  Fibrinogen-like, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade TAS
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001701 in utero embryonic development IEA
 biological_processGO:0001933 negative regulation of protein phosphorylation IEA
 biological_processGO:0002040 sprouting angiogenesis IDA
 biological_processGO:0002092 positive regulation of receptor internalization IDA
 biological_processGO:0002740 negative regulation of cytokine secretion involved in immune response IEA
 biological_processGO:0007162 negative regulation of cell adhesion IDA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA
 biological_processGO:0007171 activation of transmembrane receptor protein tyrosine kinase activity IDA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0010595 positive regulation of endothelial cell migration IDA
 biological_processGO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IEA
 biological_processGO:0014842 regulation of skeletal muscle satellite cell proliferation IDA
 biological_processGO:0030097 hemopoiesis IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030210 heparin biosynthetic process IDA
 biological_processGO:0031398 positive regulation of protein ubiquitination IDA
 biological_processGO:0031589 cell-substrate adhesion IEA
 biological_processGO:0032680 regulation of tumor necrosis factor production IEA
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IEA
 biological_processGO:0034394 protein localization to cell surface IDA
 biological_processGO:0042308 negative regulation of protein import into nucleus IEA
 biological_processGO:0043066 negative regulation of apoptotic process IDA
 biological_processGO:0043116 negative regulation of vascular permeability IDA
 biological_processGO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0043393 regulation of protein binding IEA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IEA
 biological_processGO:0043536 positive regulation of blood vessel endothelial cell migration IDA
 biological_processGO:0045785 positive regulation of cell adhesion IEA
 biological_processGO:0048014 Tie signaling pathway IEA
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IDA
 biological_processGO:0050900 leukocyte migration TAS
 biological_processGO:0050918 positive chemotaxis IDA
 biological_processGO:0051897 positive regulation of protein kinase B signaling IDA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IDA
 biological_processGO:0072012 glomerulus vasculature development ISS
 biological_processGO:2000352 negative regulation of endothelial cell apoptotic process IDA
 biological_processGO:2000446 regulation of macrophage migration inhibitory factor signaling pathway IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005902 microvillus IDA
 cellular_componentGO:0045121 membrane raft IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0005088 Ras guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0030971 receptor tyrosine kinase binding IEA


Pathways (from Reactome)
Pathway description
Tie2 Signaling
RAF/MAP kinase cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000115290 GRB14 / Q14449 / growth factor receptor bound protein 14  / reaction / complex
 ENSG00000105647 O00459 / PIK3R2 / phosphoinositide-3-kinase regulatory subunit 2  / complex / reaction
 ENSG00000147443 DOK2 / O60496 / docking protein 2  / complex / reaction
 ENSG00000160691 SHC1 / P29353 / SHC adaptor protein 1  / reaction / complex
 ENSG00000154188 ANGPT1 / Q15389 / angiopoietin 1  / complex / reaction
 ENSG00000145675 P27986 / PIK3R1 / phosphoinositide-3-kinase regulatory subunit 1  / reaction / complex
 ENSG00000177885 GRB2 / P62993 / growth factor receptor bound protein 2  / complex / reaction
 ENSG00000051382 P42338 / PIK3CB / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta  / complex / reaction
 ENSG00000121879 P42336 / PIK3CA / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha  / reaction / complex
 ENSG00000179295 PTPN11 / Q06124 / protein tyrosine phosphatase, non-receptor type 11  / complex / reaction
 ENSG00000115904 SOS1 / Q07889 / SOS Ras/Rac guanine nucleotide exchange factor 1  / reaction / complex
 ENSG00000141738 GRB7 / Q14451 / growth factor receptor bound protein 7  / complex / reaction
 ENSG00000120156 TEK / Q02763 / TEK receptor tyrosine kinase  / complex / reaction






 

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