ENSG00000166482


Homo sapiens

Features
Gene ID: ENSG00000166482
  
Biological name :MFAP4
  
Synonyms : MFAP4 / microfibril associated protein 4 / P55083
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: -1
Band: p11.2
Gene start: 19383442
Gene end: 19387240
  
Corresponding Affymetrix probe sets: 212713_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000468578
Ensembl peptide - ENSP00000299610
Ensembl peptide - ENSP00000378957
NCBI entrez gene - 4239     See in Manteia.
OMIM - 600596
RefSeq - NM_002404
RefSeq - NM_001198695
RefSeq Peptide - NP_001185624
RefSeq Peptide - NP_002395
swissprot - P55083
swissprot - A0A024QZ34
swissprot - K7ES70
Ensembl - ENSG00000166482
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FO203432.1ENSDARG00000115195Danio rerio
 mfap4ENSDARG00000090783Danio rerio
 MFAP4 (1 of many)ENSDARG00000090557Danio rerio
 si:ch1073-110a20.3ENSDARG00000096586Danio rerio
 si:zfos-2330d3.1ENSDARG00000038683Danio rerio
 wu:fj11g02ENSDARG00000038681Danio rerio
 zgc:173915ENSDARG00000089667Danio rerio
 zmp:0000001323ENSDARG00000094845Danio rerio
 Mfap4ENSMUSG00000042436Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FIBCD1 / Q8N539 / fibrinogen C domain containing 1ENSG0000013072045
FCN2 / Q15485 / ficolin 2ENSG0000016033941
FCN1 / O00602 / ficolin 1ENSG0000008526541
FCN3 / O75636 / ficolin 3ENSG0000014274837
Q8NI99 / ANGPTL6 / angiopoietin like 6ENSG0000013081237
Q9UKU9 / ANGPTL2 / angiopoietin like 2ENSG0000013685933
O43827 / ANGPTL7 / angiopoietin like 7ENSG0000017181933
ANGPT4 / Q9Y264 / angiopoietin 4ENSG0000010128033
ANGPT1 / Q15389 / angiopoietin 1ENSG0000015418833
O95841 / ANGPTL1 / angiopoietin like 1ENSG0000011619432
FGL2 / Q14314 / fibrinogen like 2ENSG0000012795132
ANGPT2 / O15123 / angiopoietin 2ENSG0000009187932


Protein motifs (from Interpro)
Interpro ID Name
 IPR002181  Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
 IPR014715  Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 2
 IPR014716  Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
 IPR036056  Fibrinogen-like, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0009650 UV protection IDA
 biological_processGO:0010712 regulation of collagen metabolic process IDA
 biological_processGO:0048251 elastic fiber assembly IDA
 biological_processGO:0071493 cellular response to UV-B IDA
 biological_processGO:0097435 supramolecular fiber organization IDA
 cellular_componentGO:0001527 microfibril NAS
 cellular_componentGO:0005576 extracellular region IDA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0031012 extracellular matrix IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0071953 elastic fiber IDA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Molecules associated with elastic fibres


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000049540 ELN / P15502 / elastin  / complex / reaction
 ENSG00000138829 FBN2 / P35556 / fibrillin 2  / complex / reaction
 ENSG00000166147 FBN1 / P35555 / fibrillin 1  / reaction / complex
 ENSG00000197614 MFAP5 / Q13361 / microfibril associated protein 5  / reaction / complex
 ENSG00000117122 MFAP2 / P55001 / microfibril associated protein 2  / complex / reaction
 ENSG00000138080 Q9Y6C2 / EMILIN1 / elastin microfibril interfacer 1  / complex / reaction






 

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