ENSG00000085265


Homo sapiens

Features
Gene ID: ENSG00000085265
  
Biological name :FCN1
  
Synonyms : FCN1 / ficolin 1 / O00602
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 9
Strand: -1
Band: q34.3
Gene start: 134905890
Gene end: 134917963
  
Corresponding Affymetrix probe sets: 205237_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000360871
Ensembl peptide - ENSP00000479379
NCBI entrez gene - 2219     See in Manteia.
OMIM - 601252
RefSeq - NM_002003
RefSeq Peptide - NP_001994
swissprot - A0A087WVE2
swissprot - O00602
Ensembl - ENSG00000085265
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000040771Gallus gallus
 FcnbENSMUSG00000026835Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FCN2 / Q15485 / ficolin 2ENSG0000016033975
FCN3 / O75636 / ficolin 3ENSG0000014274844
FIBCD1 / Q8N539 / fibrinogen C domain containing 1ENSG0000013072042
Q9UKU9 / ANGPTL2 / angiopoietin like 2ENSG0000013685936
MFAP4 / P55083 / microfibril associated protein 4ENSG0000016648235
Q8NI99 / ANGPTL6 / angiopoietin like 6ENSG0000013081234
O43827 / ANGPTL7 / angiopoietin like 7ENSG0000017181932
O95841 / ANGPTL1 / angiopoietin like 1ENSG0000011619431
FGL2 / Q14314 / fibrinogen like 2ENSG0000012795131
ANGPT1 / Q15389 / angiopoietin 1ENSG0000015418831
ANGPT4 / Q9Y264 / angiopoietin 4ENSG0000010128029
ANGPT2 / O15123 / angiopoietin 2ENSG0000009187929


Protein motifs (from Interpro)
Interpro ID Name
 IPR002181  Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
 IPR008160  Collagen triple helix repeat
 IPR014715  Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 2
 IPR014716  Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
 IPR016133  Insect cysteine-rich antifreeze protein
 IPR020837  Fibrinogen, conserved site
 IPR036056  Fibrinogen-like, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001867 complement activation, lectin pathway TAS
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002752 cell surface pattern recognition receptor signaling pathway IMP
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006956 complement activation TAS
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IDA
 biological_processGO:0034394 protein localization to cell surface IDA
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0043654 recognition of apoptotic cell IDA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0046597 negative regulation of viral entry into host cell IDA
 biological_processGO:2000484 positive regulation of interleukin-8 secretion IMP
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005581 collagen trimer IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031232 extrinsic component of external side of plasma membrane IDA
 cellular_componentGO:0034774 secretory granule lumen TAS
 cellular_componentGO:1904813 ficolin-1-rich granule lumen TAS
 molecular_functionGO:0001664 G-protein coupled receptor binding IPI
 molecular_functionGO:0004252 serine-type endopeptidase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008329 signaling pattern recognition receptor activity IMP
 molecular_functionGO:0030246 carbohydrate binding IEA
 molecular_functionGO:0033691 sialic acid binding IDA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Lectin pathway of complement activation
Initial triggering of complement
Ficolins bind to repetitive carbohydrate structures on the target cell surface
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000127241 MASP1 / P48740 / mannan binding lectin serine peptidase 1  / complex
 ENSG00000009724 MASP2 / O00187 / mannan binding lectin serine peptidase 2  / complex
 ENSG00000085265 FCN1 / O00602 / ficolin 1  / complex






 

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