ENSMUSG00000026835


Mus musculus

Features
Gene ID: ENSMUSG00000026835
  
Biological name :Fcnb
  
Synonyms : Fcnb / Ficolin-2 / O70497
  
Possible biological names infered from orthology : FCN1 / FCN2 / ficolin 1 / O00602 / Q15485
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: A3
Gene start: 28076378
Gene end: 28084885
  
Corresponding Affymetrix probe sets: 10481262 (MoGene1.0st)   1430080_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000119098
Ensembl peptide - ENSMUSP00000028179
Ensembl peptide - ENSMUSP00000112625
NCBI entrez gene - 14134     See in Manteia.
MGI - MGI:1341158
RefSeq - NM_010190
RefSeq - XM_006497676
RefSeq Peptide - NP_034320
swissprot - B2FDG6
swissprot - O70497
swissprot - Q3U9R5
Ensembl - ENSMUSG00000026835
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000040771Gallus gallus
 FCN1ENSG00000085265Homo sapiens
 FCN2ENSG00000160339Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fcna / O70165 / Ficolin-1 ENSMUSG0000002693861
A2AV25 / Fibcd1 / Fibrinogen C domain-containing protein 1 / Q8N539* / fibrinogen C domain containing 1*ENSMUSG0000002684143
Q9R045 / Angptl2 / Angiopoietin-related protein 2 / Q9UKU9* / angiopoietin like 2*ENSMUSG0000000410537
Q8R0Z6 / Angptl6 / Angiopoietin-related protein 6 / Q8NI99* / angiopoietin like 6*ENSMUSG0000003874237
Mfap4 / Q9D1H9 / Microfibril-associated glycoprotein 4 / P55083* / microfibril associated protein 4*ENSMUSG0000004243635
Q640P2 / Angptl1 / Angiopoietin-related protein 1 / O95841* / angiopoietin like 1*ENSMUSG0000003354434
Angpt4 / Q9WVH6 / Angiopoietin-4 / Q9Y264*ENSMUSG0000002746032
Angpt1 / O08538 / Angiopoietin-1 / Q15389*ENSMUSG0000002230932
Q8R1Q3 / Angptl7 / Angiopoietin-related protein 7 / O43827* / angiopoietin like 7*ENSMUSG0000002898932
Angpt2 / O35608 / Angiopoietin-2 / O15123*ENSMUSG0000003146532
Fgl2 / P12804 / Fibroleukin / Q14314* / fibrinogen like 2*ENSMUSG0000003989932


Protein motifs (from Interpro)
Interpro ID Name
 IPR002181  Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
 IPR008160  Collagen triple helix repeat
 IPR014715  Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 2
 IPR014716  Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
 IPR016133  Insect cysteine-rich antifreeze protein
 IPR020837  Fibrinogen, conserved site
 IPR036056  Fibrinogen-like, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001867 complement activation, lectin pathway IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002752 cell surface pattern recognition receptor signaling pathway ISO
 biological_processGO:0007186 G-protein coupled receptor signaling pathway ISO
 biological_processGO:0034394 protein localization to cell surface ISO
 biological_processGO:0043654 recognition of apoptotic cell ISO
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0046597 negative regulation of viral entry into host cell ISO
 biological_processGO:2000484 positive regulation of interleukin-8 secretion ISO
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005581 collagen trimer IEA
 cellular_componentGO:0031232 extrinsic component of external side of plasma membrane ISO
 molecular_functionGO:0001664 G-protein coupled receptor binding ISO
 molecular_functionGO:0008329 signaling pattern recognition receptor activity ISO
 molecular_functionGO:0030246 carbohydrate binding IEA
 molecular_functionGO:0033691 sialic acid binding ISO
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0097367 carbohydrate derivative binding IDA


Pathways (from Reactome)
Pathway description
Lectin pathway of complement activation
Initial triggering of complement
Ficolins bind to repetitive carbohydrate structures on the target cell surface
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fcgr2btm1Kgcs/Fcgr2b+
Genetic Background: involves: C57BL/6

Allelic Composition: Fcnatm1Tefu/Fcnatm1Tefu,Fcnbtm1Yend/Fcnbtm1Yend
Genetic Background: B6.129-Fcnatm1Tefu Fcnbtm1Yend

 MP:0009062 impaired lectin complement pathway "abnormal function of the plasma protein cascade triggered by binding of lectin(s) to carbohydrate groups found on pathogen cell surfaces" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fcnatm1Tefu/Fcnatm1Tefu,Fcnbtm1Yend/Fcnbtm1Yend
Genetic Background: B6.129-Fcnatm1Tefu Fcnbtm1Yend

 MP:0009788 increased susceptibility to bacterial infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fcgr2btm1Kgcs/Fcgr2b+
Genetic Background: involves: C57BL/6

Allelic Composition: Fcnatm1Tefu/Fcnatm1Tefu,Fcnbtm1Yend/Fcnbtm1Yend
Genetic Background: B6.129-Fcnatm1Tefu Fcnbtm1Yend

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000028979 Masp2 / Q91WP0 / Mannan-binding lectin serine protease 2 Mannan-binding lectin serine protease 2 A chain Mannan-binding lectin serine protease 2 B chain / O00187* / mannan binding lectin se...  / complex
 ENSMUSG00000026835 Fcnb / O70497 / Ficolin-2 / FCN1* / FCN2* / Q15485* / O00602* / ficolin 1*  / complex
 ENSMUSG00000022887 Masp1 / P98064 / Mus musculus mannan-binding lectin serine peptidase 1 (Masp1), transcript variant 1, mRNA. / P48740* / mannan binding lectin serine peptidase 1*  / complex






 

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