ENSMUSG00000038742


Mus musculus

Features
Gene ID: ENSMUSG00000038742
  
Biological name :Angptl6
  
Synonyms : Angiopoietin-related protein 6 / Angptl6 / Q8R0Z6
  
Possible biological names infered from orthology : angiopoietin like 6 / Q8NI99
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: A3
Gene start: 20873808
Gene end: 20879727
  
Corresponding Affymetrix probe sets: 10591350 (MoGene1.0st)   1424785_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000035784
NCBI entrez gene - 70726     See in Manteia.
MGI - MGI:1917976
RefSeq - XM_011242600
RefSeq - NM_145154
RefSeq - XM_011242599
RefSeq Peptide - NP_660136
swissprot - Q8R0Z6
Ensembl - ENSMUSG00000038742
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 angptl6ENSDARG00000020265Danio rerio
 Q8NI99ENSG00000130812Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9R045 / Angptl2 / Angiopoietin-related protein 2 / Q9UKU9* / angiopoietin like 2*ENSMUSG0000000410542
Q640P2 / Angptl1 / Angiopoietin-related protein 1 / O95841* / angiopoietin like 1*ENSMUSG0000003354438
A2AV25 / Fibcd1 / Fibrinogen C domain-containing protein 1 / Q8N539* / fibrinogen C domain containing 1*ENSMUSG0000002684128
Angpt4 / Q9WVH6 / Angiopoietin-4 / Q9Y264*ENSMUSG0000002746027
Angpt2 / O35608 / Angiopoietin-2 / O15123*ENSMUSG0000003146527
Angpt1 / O08538 / Angiopoietin-1 / Q15389*ENSMUSG0000002230926
Fcnb / O70497 / Ficolin-2 / FCN1* / FCN2* / Q15485* / O00602* / ficolin 1*ENSMUSG0000002683525
Fgl2 / P12804 / Fibroleukin / Q14314* / fibrinogen like 2*ENSMUSG0000003989923
Fcna / O70165 / Ficolin-1 ENSMUSG0000002693823
Mfap4 / Q9D1H9 / Microfibril-associated glycoprotein 4 / P55083* / microfibril associated protein 4*ENSMUSG0000004243622
Q8R1Q3 / Angptl7 / Angiopoietin-related protein 7 / O43827* / angiopoietin like 7*ENSMUSG0000002898922


Protein motifs (from Interpro)
Interpro ID Name
 IPR002181  Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
 IPR014715  Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 2
 IPR014716  Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
 IPR020837  Fibrinogen, conserved site
 IPR036056  Fibrinogen-like, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0030154 cell differentiation IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0030141 secretory granule IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001261 obese "excessively fat; an increase in fat in the subcutaneous connective tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Myh11tm1Peri/Myh11+
Genetic Background: involves: 129 * C57BL/6

 MP:0001554 increased circulating free fatty acid level "higher than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
Show

Allelic Composition: Myh11tm1Peri/Myh11+
Genetic Background: involves: 129 * C57BL/6

 MP:0001559 hyperglycemia "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Myh11tm1Peri/Myh11+
Genetic Background: involves: 129 * C57BL/6

 MP:0001718 abnormal yolk sac "malformed extraembryonic tissue which contributes to hematopoietic circulation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:12623]
Show

Allelic Composition: Myh11tm1Peri/Myh11+
Genetic Background: involves: 129 * C57BL/6

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Myh11tm1Peri/Myh11+
Genetic Background: involves: 129 * C57BL/6

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Myh11tm1Peri/Myh11+
Genetic Background: involves: 129 * C57BL/6

 MP:0002925 abnormal cardiovascular development "aberrant formation or incomplete differentiation of the cardiovascular system" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Myh11tm1Peri/Myh11+
Genetic Background: involves: 129 * C57BL/6

 MP:0002970 abnormal white fat morphology "structural aberration in the connective tissue consisting of fat-storing cells and arranged in lobular groups or along minor blood vessels" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Myh11tm1Peri/Myh11+
Genetic Background: involves: 129 * C57BL/6

 MP:0003229 abnormal vitelline vasculature "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]
Show

Allelic Composition: Myh11tm1Peri/Myh11+
Genetic Background: involves: 129 * C57BL/6

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Myh11tm1Peri/Myh11+
Genetic Background: involves: 129 * C57BL/6

 MP:0005290 decreased oxygen consumption "less than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Myh11tm1Peri/Myh11+
Genetic Background: involves: 129 * C57BL/6

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Myh11tm1Peri/Myh11+
Genetic Background: involves: 129 * C57BL/6

 MP:0005669 increased circulating leptin level "greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
Show

Allelic Composition: Myh11tm1Peri/Myh11+
Genetic Background: involves: 129 * C57BL/6

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myh11tm1Peri/Myh11+
Genetic Background: involves: 129 * C57BL/6

 MP:0011014 decreased core body temperature "reduced degree of heat natural to the internal center of a living being" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myh11tm1Peri/Myh11+
Genetic Background: involves: 129 * C57BL/6

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Myh11tm1Peri/Myh11+
Genetic Background: involves: 129 * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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