ENSMUSG00000026938


Mus musculus

Features
Gene ID: ENSMUSG00000026938
  
Biological name :Fcna
  
Synonyms : Fcna / Ficolin-1 / O70165
  
Possible biological names infered from orthology :
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: A3
Gene start: 25624666
Gene end: 25628030
  
Corresponding Affymetrix probe sets: 10480849 (MoGene1.0st)   1418243_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000028307
NCBI entrez gene - 14133     See in Manteia.
MGI - MGI:1340905
RefSeq - XM_011239016
RefSeq - NM_007995
RefSeq - XM_006497673
RefSeq - XM_006497675
RefSeq Peptide - NP_032021
swissprot - O70165
swissprot - Q4FJM1
Ensembl - ENSMUSG00000026938
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000040771Gallus gallus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fcnb / O70497 / Ficolin-2 / FCN1* / FCN2* / Q15485* / O00602* / ficolin 1*ENSMUSG0000002683557
A2AV25 / Fibcd1 / Fibrinogen C domain-containing protein 1 / Q8N539* / fibrinogen C domain containing 1*ENSMUSG0000002684139
Mfap4 / Q9D1H9 / Microfibril-associated glycoprotein 4 / P55083* / microfibril associated protein 4*ENSMUSG0000004243633
Q9R045 / Angptl2 / Angiopoietin-related protein 2 / Q9UKU9* / angiopoietin like 2*ENSMUSG0000000410532
Fgl2 / P12804 / Fibroleukin / Q14314* / fibrinogen like 2*ENSMUSG0000003989932
Q8R0Z6 / Angptl6 / Angiopoietin-related protein 6 / Q8NI99* / angiopoietin like 6*ENSMUSG0000003874231
Q640P2 / Angptl1 / Angiopoietin-related protein 1 / O95841* / angiopoietin like 1*ENSMUSG0000003354430
Q8R1Q3 / Angptl7 / Angiopoietin-related protein 7 / O43827* / angiopoietin like 7*ENSMUSG0000002898928
Angpt1 / O08538 / Angiopoietin-1 / Q15389*ENSMUSG0000002230928
Angpt4 / Q9WVH6 / Angiopoietin-4 / Q9Y264*ENSMUSG0000002746028
Angpt2 / O35608 / Angiopoietin-2 / O15123*ENSMUSG0000003146526


Protein motifs (from Interpro)
Interpro ID Name
 IPR002181  Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
 IPR008160  Collagen triple helix repeat
 IPR014715  Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 2
 IPR014716  Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
 IPR016133  Insect cysteine-rich antifreeze protein
 IPR020837  Fibrinogen, conserved site
 IPR036056  Fibrinogen-like, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001867 complement activation, lectin pathway IDA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002752 cell surface pattern recognition receptor signaling pathway ISS
 biological_processGO:0007186 G-protein coupled receptor signaling pathway ISS
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:2000484 positive regulation of interleukin-8 secretion ISS
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005581 collagen trimer IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031232 extrinsic component of external side of plasma membrane ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008329 signaling pattern recognition receptor activity ISS
 molecular_functionGO:0030246 carbohydrate binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0097367 carbohydrate derivative binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fcgr2btm1Kgcs/Fcgr2b+
Genetic Background: involves: C57BL/6

Allelic Composition: Fcnatm1Tefu/Fcnatm1Tefu,Fcnbtm1Yend/Fcnbtm1Yend
Genetic Background: B6.129-Fcnatm1Tefu Fcnbtm1Yend

 MP:0009062 impaired lectin complement pathway "abnormal function of the plasma protein cascade triggered by binding of lectin(s) to carbohydrate groups found on pathogen cell surfaces" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fcgr2btm1Kgcs/Fcgr2b+
Genetic Background: involves: C57BL/6

Allelic Composition: Fcnatm1Tefu/Fcnatm1Tefu,Fcnbtm1Yend/Fcnbtm1Yend
Genetic Background: B6.129-Fcnatm1Tefu Fcnbtm1Yend

 MP:0009788 increased susceptibility to bacterial infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fcgr2btm1Kgcs/Fcgr2b+
Genetic Background: involves: C57BL/6

Allelic Composition: Fcnatm1Tefu/Fcnatm1Tefu,Fcnbtm1Yend/Fcnbtm1Yend
Genetic Background: B6.129-Fcnatm1Tefu Fcnbtm1Yend

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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