ENSG00000147443


Homo sapiens

Features
Gene ID: ENSG00000147443
  
Biological name :DOK2
  
Synonyms : docking protein 2 / DOK2 / O60496
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: -1
Band: p21.3
Gene start: 21908873
Gene end: 21913860
  
Corresponding Affymetrix probe sets: 214054_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000429508
Ensembl peptide - ENSP00000430729
Ensembl peptide - ENSP00000276420
Ensembl peptide - ENSP00000429224
NCBI entrez gene - 9046     See in Manteia.
OMIM - 604997
RefSeq - XM_005273680
RefSeq - NM_001317800
RefSeq - NM_003974
RefSeq - NM_201349
RefSeq Peptide - NP_003965
RefSeq Peptide - NP_001304729
RefSeq Peptide - NP_958728
swissprot - O60496
swissprot - E5RJ11
swissprot - E5RIG9
swissprot - G3V114
Ensembl - ENSG00000147443
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 BX323022.1ENSDARG00000116593Danio rerio
 dok2ENSDARG00000075818Danio rerio
 ENSGALG00000026250Gallus gallus
 Dok2ENSMUSG00000022102Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DOK1 / Q99704 / docking protein 1ENSG0000011532538
DOK3 / Q7L591 / docking protein 3ENSG0000014609433
DOK4 / Q8TEW6 / docking protein 4ENSG0000012517017
DOK5 / Q9P104 / docking protein 5ENSG0000010113416
DOK6 / Q6PKX4 / docking protein 6ENSG0000020605216


Protein motifs (from Interpro)
Interpro ID Name
 IPR001849  Pleckstrin homology domain
 IPR002404  IRS-type PTB domain
 IPR011993  PH-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007166 cell surface receptor signaling pathway TAS
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA
 biological_processGO:0007265 Ras protein signal transduction IEA
 biological_processGO:0007411 axon guidance TAS
 biological_processGO:0050900 leukocyte migration TAS
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0005057 obsolete signal transducer activity, downstream of receptor IEA
 molecular_functionGO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Tie2 Signaling
RET signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000154188 ANGPT1 / Q15389 / angiopoietin 1  / complex / reaction
 ENSG00000120156 TEK / Q02763 / TEK receptor tyrosine kinase  / complex / reaction






 

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