ENSMUSG00000022102


Mus musculus

Features
Gene ID: ENSMUSG00000022102
  
Biological name :Dok2
  
Synonyms : Docking protein 2 / Dok2 / O70469
  
Possible biological names infered from orthology : O60496
  
Species: Mus musculus
  
Chr. number: 14
Strand: 1
Band: D2
Gene start: 70766036
Gene end: 70778495
  
Corresponding Affymetrix probe sets: 10416334 (MoGene1.0st)   1416333_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000022698
NCBI entrez gene - 13449     See in Manteia.
MGI - MGI:1332623
RefSeq - XM_017315835
RefSeq - NM_010071
RefSeq - XM_011244943
RefSeq - XM_017315834
RefSeq Peptide - NP_034201
swissprot - O70469
swissprot - Q3TX09
Ensembl - ENSMUSG00000022102
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 BX323022.1ENSDARG00000116593Danio rerio
 dok2ENSDARG00000075818Danio rerio
 ENSGALG00000026250Gallus gallus
 DOK2ENSG00000147443Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dok1 / P97465 / Docking protein 1 / Q99704*ENSMUSG0000006833535
Dok3 / Q9QZK7 / Docking protein 3 / Q7L591*ENSMUSG0000003571132
Dok4 / Q99KE3 / Docking protein 4 / Q8TEW6*ENSMUSG0000004063118
Dok6 / Q2MHE5 / Docking protein 6 / Q6PKX4*ENSMUSG0000007351417
Dok5 / Q91ZM9 / Docking protein 5 / Q9P104*ENSMUSG0000002756017


Protein motifs (from Interpro)
Interpro ID Name
 IPR001849  Pleckstrin homology domain
 IPR002404  IRS-type PTB domain
 IPR011993  PH-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade TAS
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IPI
 biological_processGO:0007265 Ras protein signal transduction IPI
 cellular_componentGO:0005622 intracellular IEA
 molecular_functionGO:0005057 obsolete signal transducer activity, downstream of receptor IPI
 molecular_functionGO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity IPI
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Tie2 Signaling
RET signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Dcntm1Ioz/Dcn+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129/Sv * Black Swiss * C57BL/6

Allelic Composition: Dok1tm1Ppp/Dok1tm1Ppp,Dok2tm1Ppp/Dok2tm1Ppp
Genetic Background: 129S1/Sv-Dok1tm1Ppp Dok2tm1Ppp

Allelic Composition: Dok1tm1Ppp/Dok1tm1Ppp,Dok2tm1Ppp/Dok2tm1Ppp,Dok3tm1Ppp/Dok3tm1Ppp
Genetic Background: 129S1/Sv-Dok1tm1Ppp Dok2tm1Ppp Dok3tm1Ppp

 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dcntm1Ioz/Dcn+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129/Sv * Black Swiss * C57BL/6

Allelic Composition: Dok1tm1Ppp/Dok1tm1Ppp,Dok2tm1Ppp/Dok2tm1Ppp
Genetic Background: 129S1/Sv-Dok1tm1Ppp Dok2tm1Ppp

 MP:0000220 increased monocyte count "greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dcntm1Ioz/Dcn+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129/Sv * Black Swiss * C57BL/6

Allelic Composition: Dok1tm1Ppp/Dok1tm1Ppp,Dok2tm1Ppp/Dok2tm1Ppp
Genetic Background: 129S1/Sv-Dok1tm1Ppp Dok2tm1Ppp

 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Dcntm1Ioz/Dcn+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129/Sv * Black Swiss * C57BL/6

 MP:0000321 increased bone marrow cell number "increased number of cells that make up the core cavitites of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Dok1tm1Ppp/Dok1tm1Ppp,Dok2tm1Ppp/Dok2tm1Ppp
Genetic Background: 129S1/Sv-Dok1tm1Ppp Dok2tm1Ppp

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dcntm1Ioz/Dcn+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129/Sv * Black Swiss * C57BL/6

Allelic Composition: Dok1tm1Ppp/Dok1tm1Ppp,Dok2tm1Ppp/Dok2tm1Ppp
Genetic Background: 129S1/Sv-Dok1tm1Ppp Dok2tm1Ppp

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dok1tm1Yyam/Dok1tm1Yyam,Dok2tm1Yyam/Dok2tm1Yyam,Tg(BCR/ABL1)5Hhi/0
Genetic Background: involves: C57BL/6

Allelic Composition: Dok2tm1Yyam/Dok2tm1Yyam,Tg(BCR/ABL1)5Hhi/0
Genetic Background: involves: C57BL/6

 MP:0000709 enlarged thymus "increased size of thymus" [J:50053]
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Allelic Composition: Dok1tm1Yyam/Dok1tm1Yyam,Dok2tm1Yyam/Dok2tm1Yyam,Tg(BCR/ABL1)5Hhi/0
Genetic Background: involves: C57BL/6

Allelic Composition: Dok2tm1Yyam/Dok2tm1Yyam,Tg(BCR/ABL1)5Hhi/0
Genetic Background: involves: C57BL/6

 MP:0001601 abnormal myelopoiesis "atypical process of bone marrow cell formation and/or bone marrow-derived blood cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
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Allelic Composition: Dcntm1Ioz/Dcn+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129/Sv * Black Swiss * C57BL/6

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
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Allelic Composition: Dok1tm1Yyam/Dok1tm1Yyam,Dok2tm1Yyam/Dok2tm1Yyam,Dok3tm1Brs/Dok3tm1Brs
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0002026 leukemia "progressive proliferation of abnormal leukocytes in hematopoietic tissues, organs and blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18542]
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Allelic Composition: Dcntm1Ioz/Dcn+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129/Sv * Black Swiss * C57BL/6

Allelic Composition: Dok1tm1Yyam/Dok1tm1Yyam,Dok2tm1Yyam/Dok2tm1Yyam,Tg(BCR/ABL1)5Hhi/0
Genetic Background: involves: C57BL/6

Allelic Composition: Dok2tm1Yyam/Dok2tm1Yyam,Tg(BCR/ABL1)5Hhi/0
Genetic Background: involves: C57BL/6

Allelic Composition: Dok1tm1Ppp/Dok1tm1Ppp,Dok2tm1Ppp/Dok2tm1Ppp
Genetic Background: 129S1/Sv-Dok1tm1Ppp Dok2tm1Ppp

Allelic Composition: Dok2tm1Ppp/Dok2tm1Ppp,Tg(BCR/ABL1)5Hhi/0
Genetic Background: involves: 129S1/Sv

Allelic Composition: Dok2tm1Ppp/Dok2+,Tg(BCR/ABL1)5Hhi/0
Genetic Background: involves: 129S1/Sv

 MP:0002027 lung adenocarcinoma "malignant neoplasm of epithelial cells in the lung" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:18542]
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Allelic Composition: Dok1tm1Ppp/Dok1tm1Ppp,Tg(BCR/ABL1)5Hhi/0
Genetic Background: involves: 129S1/Sv

Allelic Composition: Dok1tm1Ppp/Dok1tm1Ppp,Dok2tm1Ppp/Dok2tm1Ppp
Genetic Background: 129S1/Sv-Dok1tm1Ppp Dok2tm1Ppp

Allelic Composition: Dok1tm1Ppp/Dok1tm1Ppp,Dok2tm1Ppp/Dok2tm1Ppp,Dok3tm1Ppp/Dok3tm1Ppp
Genetic Background: 129S1/Sv-Dok1tm1Ppp Dok2tm1Ppp Dok3tm1Ppp

 MP:0002032 sarcoma "connective tissue neoplasm associated with the proliferation of mesodermal cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
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Allelic Composition: Dcntm1Ioz/Dcn+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129/Sv * Black Swiss * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dok1tm1Yyam/Dok1tm1Yyam,Dok2tm1Yyam/Dok2tm1Yyam,Tg(BCR/ABL1)5Hhi/0
Genetic Background: involves: C57BL/6

Allelic Composition: Dok2tm1Yyam/Dok2tm1Yyam,Tg(BCR/ABL1)5Hhi/0
Genetic Background: involves: C57BL/6

Allelic Composition: Dok2tm1Ppp/Dok2tm1Ppp,Tg(BCR/ABL1)5Hhi/0
Genetic Background: involves: 129S1/Sv

Allelic Composition: Dok2tm1Ppp/Dok2+,Tg(BCR/ABL1)5Hhi/0
Genetic Background: involves: 129S1/Sv

Allelic Composition: Dok1tm1Ppp/Dok1tm1Ppp,Dok2tm1Ppp/Dok2tm1Ppp,Dok3tm1Ppp/Dok3tm1Ppp
Genetic Background: 129S1/Sv-Dok1tm1Ppp Dok2tm1Ppp Dok3tm1Ppp

Allelic Composition: Dok1tm1Yyam/Dok1tm1Yyam,Dok2tm1Yyam/Dok2tm1Yyam,Dok3tm1Brs/Dok3tm1Brs
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0002270 abnormal alveoli morphology "any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dok1tm1Ppp/Dok1tm1Ppp,Dok2tm1Ppp/Dok2tm1Ppp,Dok3tm1Ppp/Dok3tm1Ppp
Genetic Background: 129S1/Sv-Dok1tm1Ppp Dok2tm1Ppp Dok3tm1Ppp

 MP:0002442 abnormal leukocyte physiology "abnormal function of any of the white blood cells (basophils, eosinophils, neutrophils, lymphocytes, or monocytes) " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Dcntm1Ioz/Dcn+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129/Sv * Black Swiss * C57BL/6

Allelic Composition: Dok1tm1Ppp/Dok1tm1Ppp,Dok2tm1Ppp/Dok2tm1Ppp
Genetic Background: 129S1/Sv-Dok1tm1Ppp Dok2tm1Ppp

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: F2rtm1Pago/F2rtm1Pago,F3tm1.1Dwr/F3tm1.1Dwr
Genetic Background: B6.129-F3tm1.1Dwr F2rtm1Pago

Allelic Composition: Dok1tm1Yyam/Dok1tm1Yyam,Dok2tm1Yyam/Dok2tm1Yyam,Dok3tm1Brs/Dok3tm1Brs
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0002462 abnormal granulocyte physiology "functional anomaly of neutrophils, eosinophils, or basophils " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dok1tm1Ppp/Dok1tm1Ppp,Tg(BCR/ABL1)5Hhi/0
Genetic Background: involves: 129S1/Sv

 MP:0004202 pulmonary hyperplasia "overdevelopment or increased size, usually due an increased number of cells of the respiratory organ in all or part of the organ" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dok1tm1Ppp/Dok1tm1Ppp,Dok2tm1Ppp/Dok2tm1Ppp,Dok3tm1Ppp/Dok3tm1Ppp
Genetic Background: 129S1/Sv-Dok1tm1Ppp Dok2tm1Ppp Dok3tm1Ppp

 MP:0005425 increased macrophage count "greater than the normal numbers of macrophages" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:73418]
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Allelic Composition: Dok1tm1Yyam/Dok1tm1Yyam,Dok2tm1Yyam/Dok2tm1Yyam,Dok3tm1Brs/Dok3tm1Brs
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0005481 chronic myelocytic leukemia "a heterogeneous group of myeloproliferative disorders that may evolve into acute leukemia in late stages " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Dok1tm1Ppp/Dok1tm1Ppp,Dok2tm1Ppp/Dok2tm1Ppp,Dok3tm1Ppp/Dok3tm1Ppp
Genetic Background: 129S1/Sv-Dok1tm1Ppp Dok2tm1Ppp Dok3tm1Ppp

 MP:0008014 lung tumor "presence of abnormal, rapidly proliferating cells on the lung usually in the form of a distinct mass" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Dok1tm1Ppp/Dok1tm1Ppp,Dok2tm1Ppp/Dok2tm1Ppp,Dok3tm1Ppp/Dok3tm1Ppp
Genetic Background: 129S1/Sv-Dok1tm1Ppp Dok2tm1Ppp Dok3tm1Ppp

Allelic Composition: Dok2tm1Ppp/Dok2+
Genetic Background: 129S1/Sv-Dok2tm1Ppp

 MP:0008254 increased megakaryocyte cell number "greater number of giant cells 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow; mature blood platelets are released from its cytoplasm" [CL:0000556, ISBN:0721601464]
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Allelic Composition: Dcntm1Ioz/Dcn+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129/Sv * Black Swiss * C57BL/6

 MP:0009321 histiocytic sarcoma 
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Allelic Composition: Dok1tm1Yyam/Dok1tm1Yyam,Dok2tm1Yyam/Dok2tm1Yyam,Dok3tm1Brs/Dok3tm1Brs
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0010810 increased type II pneumocyte number "greater number of the granular and roughly cuboidal cells typically found at the alveolar-septal junction that modulate the fluid surrounding the alveolar epithelium by secreting and recycling surfactants, and also contribute to tissue repair and can differentiate after injury into a type I pneumocyte; type II cells cover a much smaller surface area than type I cells (less than 5 percent), but are much more numerous and contain lamellar bodies on the apical surface where surfactant is stored" [ISBN:0412046911, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", PMID:8540632]
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Allelic Composition: Dok1tm1Ppp/Dok1tm1Ppp,Dok2tm1Ppp/Dok2tm1Ppp,Dok3tm1Ppp/Dok3tm1Ppp
Genetic Background: 129S1/Sv-Dok1tm1Ppp Dok2tm1Ppp Dok3tm1Ppp

 MP:0010829 increased bronchioalveolar stem cell number 
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Allelic Composition: Dok1tm1Ppp/Dok1tm1Ppp,Dok2tm1Ppp/Dok2tm1Ppp,Dok3tm1Ppp/Dok3tm1Ppp
Genetic Background: 129S1/Sv-Dok1tm1Ppp Dok2tm1Ppp Dok3tm1Ppp

 MP:0011178 increased erythroblast number "greater number of the nucleated precursor of erythrocytes" [MGI:csmith]
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Allelic Composition: Dcntm1Ioz/Dcn+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129/Sv * Black Swiss * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000022309 Angpt1 / O08538 / Angiopoietin-1 / Q15389*  / reaction / complex
 ENSMUSG00000006386 Tek / Q02858 / TEK receptor tyrosine kinase / Q02763*  / reaction / complex






 

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