ENSMUSG00000068335


Mus musculus

Features
Gene ID: ENSMUSG00000068335
  
Biological name :Dok1
  
Synonyms : Docking protein 1 / Dok1 / P97465
  
Possible biological names infered from orthology : Q99704
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: C3
Gene start: 83030934
Gene end: 83033471
  
Corresponding Affymetrix probe sets: 10545623 (MoGene1.0st)   1417790_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000145318
Ensembl peptide - ENSMUSP00000145347
Ensembl peptide - ENSMUSP00000087079
NCBI entrez gene - 13448     See in Manteia.
MGI - MGI:893587
RefSeq - NM_010070
RefSeq - NM_001291799
RefSeq Peptide - NP_001278728
RefSeq Peptide - NP_034200
swissprot - P97465
swissprot - A0A0N4SW29
swissprot - A0A0N4SW01
Ensembl - ENSMUSG00000068335
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dok1aENSDARG00000078108Danio rerio
 dok1bENSDARG00000099177Danio rerio
 DOK1ENSG00000115325Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dok2 / O70469 / Docking protein 2 / O60496*ENSMUSG0000002210230
Dok3 / Q9QZK7 / Docking protein 3 / Q7L591*ENSMUSG0000003571128
Dok6 / Q2MHE5 / Docking protein 6 / Q6PKX4*ENSMUSG0000007351416
Dok4 / Q99KE3 / Docking protein 4 / Q8TEW6*ENSMUSG0000004063116
Dok5 / Q91ZM9 / Docking protein 5 / Q9P104*ENSMUSG0000002756015


Protein motifs (from Interpro)
Interpro ID Name
 IPR001849  Pleckstrin homology domain
 IPR002404  IRS-type PTB domain
 IPR011993  PH-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade TAS
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IPI
 biological_processGO:0007265 Ras protein signal transduction IPI
 biological_processGO:0035556 intracellular signal transduction IPI
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0005057 obsolete signal transducer activity, downstream of receptor IPI
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
RET signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Dcntm1Ioz/Dcn+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129/Sv * Black Swiss * C57BL/6

Allelic Composition: Dok1tm1Ppp/Dok1tm1Ppp,Dok2tm1Ppp/Dok2tm1Ppp
Genetic Background: 129S1/Sv-Dok1tm1Ppp Dok2tm1Ppp

Allelic Composition: Dok1tm1Ppp/Dok1tm1Ppp,Dok2tm1Ppp/Dok2tm1Ppp,Dok3tm1Ppp/Dok3tm1Ppp
Genetic Background: 129S1/Sv-Dok1tm1Ppp Dok2tm1Ppp Dok3tm1Ppp

 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dcntm1Ioz/Dcn+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129/Sv * Black Swiss * C57BL/6

Allelic Composition: Dok1tm1Ppp/Dok1tm1Ppp,Dok2tm1Ppp/Dok2tm1Ppp
Genetic Background: 129S1/Sv-Dok1tm1Ppp Dok2tm1Ppp

 MP:0000220 increased monocyte count "greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dcntm1Ioz/Dcn+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129/Sv * Black Swiss * C57BL/6

Allelic Composition: Dok1tm1Ppp/Dok1tm1Ppp,Dok2tm1Ppp/Dok2tm1Ppp
Genetic Background: 129S1/Sv-Dok1tm1Ppp Dok2tm1Ppp

 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Dcntm1Ioz/Dcn+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129/Sv * Black Swiss * C57BL/6

 MP:0000321 increased bone marrow cell number "increased number of cells that make up the core cavitites of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Dok1tm1Ppp/Dok1tm1Ppp,Dok2tm1Ppp/Dok2tm1Ppp
Genetic Background: 129S1/Sv-Dok1tm1Ppp Dok2tm1Ppp

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dcntm1Ioz/Dcn+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129/Sv * Black Swiss * C57BL/6

Allelic Composition: Dok1tm1Ppp/Dok1tm1Ppp,Dok2tm1Ppp/Dok2tm1Ppp
Genetic Background: 129S1/Sv-Dok1tm1Ppp Dok2tm1Ppp

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dok1tm1Yyam/Dok1tm1Yyam,Tg(BCR/ABL1)5Hhi/0
Genetic Background: involves: C57BL/6

Allelic Composition: Dok1tm1Yyam/Dok1tm1Yyam,Dok2tm1Yyam/Dok2tm1Yyam,Tg(BCR/ABL1)5Hhi/0
Genetic Background: involves: C57BL/6

 MP:0000709 enlarged thymus "increased size of thymus" [J:50053]
Show

Allelic Composition: Dok1tm1Yyam/Dok1tm1Yyam,Tg(BCR/ABL1)5Hhi/0
Genetic Background: involves: C57BL/6

Allelic Composition: Dok1tm1Yyam/Dok1tm1Yyam,Dok2tm1Yyam/Dok2tm1Yyam,Tg(BCR/ABL1)5Hhi/0
Genetic Background: involves: C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Cacna1aTg-5J/Cacna1a+
Genetic Background: B10.Cg-Cacna1aTg-5J

 MP:0001601 abnormal myelopoiesis "atypical process of bone marrow cell formation and/or bone marrow-derived blood cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
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Allelic Composition: Dcntm1Ioz/Dcn+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129/Sv * Black Swiss * C57BL/6

 MP:0001806 decreased IgM "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dcntm1Ioz/Dcn+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129/Sv * Black Swiss * C57BL/6

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
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Allelic Composition: Dok1tm1Yyam/Dok1tm1Yyam,Dok2tm1Yyam/Dok2tm1Yyam,Dok3tm1Brs/Dok3tm1Brs
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0002026 leukemia "progressive proliferation of abnormal leukocytes in hematopoietic tissues, organs and blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18542]
Show

Allelic Composition: Dcntm1Ioz/Dcn+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129/Sv * Black Swiss * C57BL/6

Allelic Composition: Dok1tm1Yyam/Dok1tm1Yyam,Tg(BCR/ABL1)5Hhi/0
Genetic Background: involves: C57BL/6

Allelic Composition: Dok1tm1Yyam/Dok1tm1Yyam,Dok2tm1Yyam/Dok2tm1Yyam,Tg(BCR/ABL1)5Hhi/0
Genetic Background: involves: C57BL/6

Allelic Composition: Dok1tm1Ppp/Dok1tm1Ppp,Tg(BCR/ABL1)5Hhi/0
Genetic Background: involves: 129S1/Sv

Allelic Composition: Dok1tm1Ppp/Dok1tm1Ppp,Dok2tm1Ppp/Dok2tm1Ppp
Genetic Background: 129S1/Sv-Dok1tm1Ppp Dok2tm1Ppp

Allelic Composition: Dok1tm1Ppp/Dok1+,Tg(BCR/ABL1)5Hhi/0
Genetic Background: involves: 129S1/Sv

 MP:0002027 lung adenocarcinoma "malignant neoplasm of epithelial cells in the lung" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:18542]
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Allelic Composition: Dok2tm1Yyam/Dok2tm1Yyam,Tg(BCR/ABL1)5Hhi/0
Genetic Background: involves: C57BL/6

Allelic Composition: Dok1tm1Ppp/Dok1tm1Ppp,Dok2tm1Ppp/Dok2tm1Ppp
Genetic Background: 129S1/Sv-Dok1tm1Ppp Dok2tm1Ppp

Allelic Composition: Dok1tm1Ppp/Dok1tm1Ppp,Dok2tm1Ppp/Dok2tm1Ppp,Dok3tm1Ppp/Dok3tm1Ppp
Genetic Background: 129S1/Sv-Dok1tm1Ppp Dok2tm1Ppp Dok3tm1Ppp

Allelic Composition: Dok1tm1Ppp/Dok1tm1Ppp,Dok3tm1Ppp/Dok3tm1Ppp
Genetic Background: 129S1/Sv-Dok1tm1Ppp Dok3tm1Ppp

 MP:0002032 sarcoma "connective tissue neoplasm associated with the proliferation of mesodermal cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
Show

Allelic Composition: Dcntm1Ioz/Dcn+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129/Sv * Black Swiss * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dcntm1Ioz/Dcn+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129/Sv * Black Swiss * C57BL/6

Allelic Composition: Dok1tm1Yyam/Dok1tm1Yyam,Dok2tm1Yyam/Dok2tm1Yyam,Tg(BCR/ABL1)5Hhi/0
Genetic Background: involves: C57BL/6

Allelic Composition: Dok1tm1Ppp/Dok1tm1Ppp,Tg(BCR/ABL1)5Hhi/0
Genetic Background: involves: 129S1/Sv

Allelic Composition: Dok1tm1Ppp/Dok1+,Tg(BCR/ABL1)5Hhi/0
Genetic Background: involves: 129S1/Sv

Allelic Composition: Dok1tm1Ppp/Dok1tm1Ppp,Dok2tm1Ppp/Dok2tm1Ppp,Dok3tm1Ppp/Dok3tm1Ppp
Genetic Background: 129S1/Sv-Dok1tm1Ppp Dok2tm1Ppp Dok3tm1Ppp

Allelic Composition: Dok1tm1Yyam/Dok1tm1Yyam,Dok2tm1Yyam/Dok2tm1Yyam,Dok3tm1Brs/Dok3tm1Brs
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0002270 abnormal alveoli morphology "any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dok1tm1Ppp/Dok1tm1Ppp,Dok2tm1Ppp/Dok2tm1Ppp,Dok3tm1Ppp/Dok3tm1Ppp
Genetic Background: 129S1/Sv-Dok1tm1Ppp Dok2tm1Ppp Dok3tm1Ppp

 MP:0002398 abnormal bone marrow cell morphology/development "anomalous structure or formation of the cells found in the bone marrow" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dok2tm1Yyam/Dok2tm1Yyam,Tg(BCR/ABL1)5Hhi/0
Genetic Background: involves: C57BL/6

 MP:0002442 abnormal leukocyte physiology "abnormal function of any of the white blood cells (basophils, eosinophils, neutrophils, lymphocytes, or monocytes) " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Dcntm1Ioz/Dcn+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129/Sv * Black Swiss * C57BL/6

Allelic Composition: Dok1tm1Ppp/Dok1tm1Ppp,Dok2tm1Ppp/Dok2tm1Ppp
Genetic Background: 129S1/Sv-Dok1tm1Ppp Dok2tm1Ppp

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: F2rtm1Pago/F2rtm1Pago,F3tm1.1Dwr/F3tm1.1Dwr
Genetic Background: B6.129-F3tm1.1Dwr F2rtm1Pago

Allelic Composition: Dok1tm1Yyam/Dok1tm1Yyam,Dok2tm1Yyam/Dok2tm1Yyam,Dok3tm1Brs/Dok3tm1Brs
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cacna1aTg-5J/Cacna1a+
Genetic Background: B10.Cg-Cacna1aTg-5J

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Cacna1aTg-5J/Cacna1a+
Genetic Background: B10.Cg-Cacna1aTg-5J

 MP:0004202 pulmonary hyperplasia "overdevelopment or increased size, usually due an increased number of cells of the respiratory organ in all or part of the organ" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dok1tm1Ppp/Dok1tm1Ppp,Dok2tm1Ppp/Dok2tm1Ppp,Dok3tm1Ppp/Dok3tm1Ppp
Genetic Background: 129S1/Sv-Dok1tm1Ppp Dok2tm1Ppp Dok3tm1Ppp

 MP:0004892 increased adiponectin level "greater level of a protein hormone that regulates glucose homeostasis and metabolism of lipids; it is normally produced by adipose tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cacna1aTg-5J/Cacna1a+
Genetic Background: B10.Cg-Cacna1aTg-5J

 MP:0005094 abnormal T cell proliferation "anomaly in the clonal expansion of naive T cells" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Dok2tm1Yyam/Dok2tm1Yyam,Tg(BCR/ABL1)5Hhi/0
Genetic Background: involves: C57BL/6

 MP:0005154 increased B cell proliferation "greater than the normal response by B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dcntm1Ioz/Dcn+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129/Sv * Black Swiss * C57BL/6

 MP:0005289 increased oxygen consumption "greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cacna1aTg-5J/Cacna1a+
Genetic Background: B10.Cg-Cacna1aTg-5J

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cacna1aTg-5J/Cacna1a+
Genetic Background: B10.Cg-Cacna1aTg-5J

 MP:0005425 increased macrophage count "greater than the normal numbers of macrophages" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:73418]
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Allelic Composition: Dok1tm1Yyam/Dok1tm1Yyam,Dok2tm1Yyam/Dok2tm1Yyam,Dok3tm1Brs/Dok3tm1Brs
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0005459 decreased percent body fat "less fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cacna1aTg-5J/Cacna1a+
Genetic Background: B10.Cg-Cacna1aTg-5J

 MP:0005481 chronic myelocytic leukemia "a heterogeneous group of myeloproliferative disorders that may evolve into acute leukemia in late stages " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Dok1tm1Ppp/Dok1tm1Ppp,Dok2tm1Ppp/Dok2tm1Ppp,Dok3tm1Ppp/Dok3tm1Ppp
Genetic Background: 129S1/Sv-Dok1tm1Ppp Dok2tm1Ppp Dok3tm1Ppp

 MP:0005668 decreased circulating leptin level "less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: Cacna1aTg-5J/Cacna1a+
Genetic Background: B10.Cg-Cacna1aTg-5J

 MP:0008014 lung tumor "presence of abnormal, rapidly proliferating cells on the lung usually in the form of a distinct mass" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Dok1tm1Ppp/Dok1tm1Ppp,Dok2tm1Ppp/Dok2tm1Ppp,Dok3tm1Ppp/Dok3tm1Ppp
Genetic Background: 129S1/Sv-Dok1tm1Ppp Dok2tm1Ppp Dok3tm1Ppp

 MP:0008254 increased megakaryocyte cell number "greater number of giant cells 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow; mature blood platelets are released from its cytoplasm" [CL:0000556, ISBN:0721601464]
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Allelic Composition: Dcntm1Ioz/Dcn+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129/Sv * Black Swiss * C57BL/6

 MP:0009115 abnormal fat cell morphology "any structural anomaly of a fat-storing cell found mostly in the abdominal cavity and subcutaneous tissue of mammals" [CL:0000449]
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Allelic Composition: Dok1tm1Yyam/Dok1tm1Yyam,Ppargtm1Laz/Ppargtm1Laz
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0009269 decreased fat cell size "reduction in the size of fat-storing cells found mostly in the abdominal cavity and subcutaneous tissue of mammals" [CL:0000449]
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Allelic Composition: Cacna1aTg-5J/Cacna1a+
Genetic Background: B10.Cg-Cacna1aTg-5J

 MP:0009289 decreased epididymal fat pad weight 
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Allelic Composition: Cacna1aTg-5J/Cacna1a+
Genetic Background: B10.Cg-Cacna1aTg-5J

 MP:0009293 decreased inguinal fat pad weight 
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Allelic Composition: Cacna1aTg-5J/Cacna1a+
Genetic Background: B10.Cg-Cacna1aTg-5J

 MP:0009321 histiocytic sarcoma 
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Allelic Composition: Dok1tm1Yyam/Dok1tm1Yyam,Dok2tm1Yyam/Dok2tm1Yyam,Dok3tm1Brs/Dok3tm1Brs
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0010182 decreased susceptibility to weight gain "smaller increase in body weight over time when compared to the average increase in weight on the same diet, with equal energy (calorie) intake" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cacna1aTg-5J/Cacna1a+
Genetic Background: B10.Cg-Cacna1aTg-5J

 MP:0010810 increased type II pneumocyte number "greater number of the granular and roughly cuboidal cells typically found at the alveolar-septal junction that modulate the fluid surrounding the alveolar epithelium by secreting and recycling surfactants, and also contribute to tissue repair and can differentiate after injury into a type I pneumocyte; type II cells cover a much smaller surface area than type I cells (less than 5 percent), but are much more numerous and contain lamellar bodies on the apical surface where surfactant is stored" [ISBN:0412046911, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", PMID:8540632]
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Allelic Composition: Dok1tm1Ppp/Dok1tm1Ppp,Dok2tm1Ppp/Dok2tm1Ppp,Dok3tm1Ppp/Dok3tm1Ppp
Genetic Background: 129S1/Sv-Dok1tm1Ppp Dok2tm1Ppp Dok3tm1Ppp

 MP:0010829 increased bronchioalveolar stem cell number 
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Allelic Composition: Dok1tm1Ppp/Dok1tm1Ppp,Dok2tm1Ppp/Dok2tm1Ppp,Dok3tm1Ppp/Dok3tm1Ppp
Genetic Background: 129S1/Sv-Dok1tm1Ppp Dok2tm1Ppp Dok3tm1Ppp

 MP:0011178 increased erythroblast number "greater number of the nucleated precursor of erythrocytes" [MGI:csmith]
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Allelic Composition: Dcntm1Ioz/Dcn+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129/Sv * Black Swiss * C57BL/6

 MP:0011703 increased fibroblast proliferation "greater the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
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Allelic Composition: Dok2tm1Yyam/Dok2tm1Yyam,Tg(BCR/ABL1)5Hhi/0
Genetic Background: involves: C57BL/6

 MP:0014169 decreased brown adipose tissue mass "decreased physical bulk or volume of brown adipose tissue" [MGI:csmith]
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Allelic Composition: Cacna1aTg-5J/Cacna1a+
Genetic Background: B10.Cg-Cacna1aTg-5J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000038751 Ptk6 / Q64434 / PTK6 protein tyrosine kinase 6 / Q13882* / protein tyrosine kinase 6*  / complex / reaction






 

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