ENSG00000115325


Homo sapiens

Features
Gene ID: ENSG00000115325
  
Biological name :DOK1
  
Synonyms : docking protein 1 / DOK1 / Q99704
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: p13.1
Gene start: 74549026
Gene end: 74557554
  
Corresponding Affymetrix probe sets: 211121_s_at (Human Genome U133 Plus 2.0 Array)   216835_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000233668
Ensembl peptide - ENSP00000344330
Ensembl peptide - ENSP00000387016
Ensembl peptide - ENSP00000393586
NCBI entrez gene - 1796     See in Manteia.
OMIM - 602919
RefSeq - NM_001381
RefSeq - XM_017003528
RefSeq - NM_001197260
RefSeq - NM_001318866
RefSeq - NM_001318867
RefSeq - NM_001318868
RefSeq - NM_001318869
RefSeq Peptide - NP_001184189
RefSeq Peptide - NP_001305795
RefSeq Peptide - NP_001305796
RefSeq Peptide - NP_001305797
RefSeq Peptide - NP_001305798
RefSeq Peptide - NP_001372
swissprot - Q99704
swissprot - H7C093
Ensembl - ENSG00000115325
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dok1aENSDARG00000078108Danio rerio
 dok1bENSDARG00000099177Danio rerio
 Dok1ENSMUSG00000068335Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DOK2 / O60496 / docking protein 2ENSG0000014744333
DOK3 / Q7L591 / docking protein 3ENSG0000014609430
DOK4 / Q8TEW6 / docking protein 4ENSG0000012517017
DOK5 / Q9P104 / docking protein 5ENSG0000010113416
DOK6 / Q6PKX4 / docking protein 6ENSG0000020605216


Protein motifs (from Interpro)
Interpro ID Name
 IPR001849  Pleckstrin homology domain
 IPR002404  IRS-type PTB domain
 IPR011993  PH-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007166 cell surface receptor signaling pathway TAS
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway TAS
 biological_processGO:0007265 Ras protein signal transduction IEA
 biological_processGO:0007411 axon guidance TAS
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0045742 positive regulation of epidermal growth factor receptor signaling pathway TAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0005057 obsolete signal transducer activity, downstream of receptor IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
RET signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000101213 PTK6 / Q13882 / protein tyrosine kinase 6  / reaction / complex






 

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