ENSMUSG00000002602


Mus musculus

Features
Gene ID: ENSMUSG00000002602
  
Biological name :Axl
  
Synonyms : Axl / AXL receptor tyrosine kinase / Q00993
  
Possible biological names infered from orthology : P30530
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: A3
Gene start: 25757273
Gene end: 25788705
  
Corresponding Affymetrix probe sets: 10561104 (MoGene1.0st)   1423586_at (Mouse Genome 430 2.0 Array)   1438621_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000002677
Ensembl peptide - ENSMUSP00000083110
Ensembl peptide - ENSMUSP00000114907
NCBI entrez gene - 26362     See in Manteia.
MGI - MGI:1347244
RefSeq - XM_006539993
RefSeq - NM_001190974
RefSeq - NM_001190975
RefSeq - NM_009465
RefSeq - XM_006539989
RefSeq - XM_006539991
RefSeq - XM_006539992
RefSeq Peptide - NP_001177903
RefSeq Peptide - NP_001177904
RefSeq Peptide - NP_033491
swissprot - Q00993
swissprot - Q6PE80
swissprot - F6YPR4
Ensembl - ENSMUSG00000002602
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 AXLENSDARG00000112045Danio rerio
 AXLENSG00000167601Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mertk / Q60805 / Tyrosine-protein kinase Mer / Q12866* / MER proto-oncogene, tyrosine kinase*ENSMUSG0000001436143
Tyro3 / P55144 / TYRO3 protein tyrosine kinase 3 / Q06418* / TYRO3 protein tyrosine kinase*ENSMUSG0000002729840
Mst1r / Q62190 / macrophage stimulating 1 receptor (c-met-related tyrosine kinase) / Q04912* / macrophage stimulating 1 receptor*ENSMUSG0000003258424
Tie1 / Q06806 / tyrosine kinase with immunoglobulin-like and EGF-like domains 1 / P35590*ENSMUSG0000003319123
Tek / Q02858 / TEK receptor tyrosine kinase / Q02763*ENSMUSG0000000638622
Met / MET proto-oncogene, receptor tyrosine kinase / P08581*ENSMUSG0000000937622
Ryk / Q01887 / Tyrosine-protein kinase RYK / receptor-like tyrosine kinase*ENSMUSG0000003254718


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR003599  Immunoglobulin subtype
 IPR003961  Fibronectin type III
 IPR007110  Immunoglobulin-like domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR013783  Immunoglobulin-like fold
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR036116  Fibronectin type III superfamily
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001764 neuron migration IMP
 biological_processGO:0001779 natural killer cell differentiation IGI
 biological_processGO:0001818 negative regulation of cytokine production IGI
 biological_processGO:0001961 positive regulation of cytokine-mediated signaling pathway IEA
 biological_processGO:0001974 blood vessel remodeling IMP
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006909 phagocytosis IEA
 biological_processGO:0006954 inflammatory response IMP
 biological_processGO:0007167 enzyme linked receptor protein signaling pathway IGI
 biological_processGO:0007283 spermatogenesis IGI
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0021885 forebrain cell migration IGI
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030168 platelet activation IMP
 biological_processGO:0031100 animal organ regeneration IEA
 biological_processGO:0031668 cellular response to extracellular stimulus IDA
 biological_processGO:0032689 negative regulation of interferon-gamma production IEA
 biological_processGO:0032720 negative regulation of tumor necrosis factor production IGI
 biological_processGO:0032825 positive regulation of natural killer cell differentiation IEA
 biological_processGO:0032940 secretion by cell IMP
 biological_processGO:0034101 erythrocyte homeostasis IMP
 biological_processGO:0034446 substrate adhesion-dependent cell spreading IMP
 biological_processGO:0035457 cellular response to interferon-alpha IEA
 biological_processGO:0042698 ovulation cycle IGI
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043277 apoptotic cell clearance IMP
 biological_processGO:0043491 protein kinase B signaling IMP
 biological_processGO:0043524 negative regulation of neuron apoptotic process IMP
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0046718 viral entry into host cell IEA
 biological_processGO:0048469 cell maturation IEA
 biological_processGO:0048549 positive regulation of pinocytosis IEA
 biological_processGO:0051250 negative regulation of lymphocyte activation IGI
 biological_processGO:0051897 positive regulation of protein kinase B signaling IMP
 biological_processGO:0060068 vagina development IGI
 biological_processGO:0070301 cellular response to hydrogen peroxide IEA
 biological_processGO:0071222 cellular response to lipopolysaccharide IEA
 biological_processGO:0097028 dendritic cell differentiation IEA
 biological_processGO:0097350 neutrophil clearance IGI
 biological_processGO:2000669 negative regulation of dendritic cell apoptotic process IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0044228 host cell surface IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0001786 phosphatidylserine binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004714 transmembrane receptor protein tyrosine kinase activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0032036 myosin heavy chain binding IEA
 molecular_functionGO:0043548 phosphatidylinositol 3-kinase binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IPI


Pathways (from Reactome)
Pathway description
VEGFA-VEGFR2 Pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Axltm1Grl/Axltm1Grl,Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

 MP:0000783 abnormal forebrain morphology "malformed or absent anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Axltm1Grl/Axltm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Axltm1Grl/Axltm1Grl,Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000807 abnormal hippocampus morphology "absent or malformed deep lying structure of the cerebrum involved with memory storage and spatial navigation" [The Atlas of Mouse Development:ISBN 0-12-402035-6, MGI:Cls, J:38857]
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Allelic Composition: Axltm1Grl/Axltm1Grl,Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000849 abnormal cerebellum morphology "any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Axltm1Grl/Axltm1Grl,Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001120 abnormal uterus morphology "malformation or absence of the female muscular organ of gestation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

 MP:0001144 fused vaginal opening "condition in which the external vaginal opening is closed by the adherence of the epithelium of the vagina" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Axltm1Grl/Axltm1Grl,Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Axltm1Grl/Axltm1Grl,Mertktm1Grl/Mertktm1Grl
Genetic Background: involves: C57BL/6J

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

Allelic Composition: Axltm1Grl/Axltm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

Allelic Composition: Axltm1Grl/Axltm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001168 prostate epithelial dysplasia "abnormal development of the prostate epithelium" [J:63764]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

 MP:0001212 skin lesions "focal patches of inflammation on the skin" [J:30162]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

 MP:0001634 internal hemorrhage "blood loss in the interior of the body due to vessel rupture or dysmorphology " [J:23170]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

 MP:0001648 abnormal apoptosis "excessive or absent cell death in a particular tissue or cell type" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:25248]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

 MP:0001828 abnormal T cell activation "anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Axltm1Grl/Axltm1Grl,Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

 MP:0001938 delayed sexual maturation "immaturity of the sexual organs at a given age" [J:61190]
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Allelic Composition: Axltm1Grl/Axltm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002001 blindness "loss of the sense of sight" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Axltm1Grl/Axltm1Grl,Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Selptm1Bay/Selptm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

 MP:0002425 altered susceptibility to autoimmune disorder "a change in the likelihood that an organism will develop disease characterized by production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Axltm1Grl/Axltm1Grl,Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Axltm1Grl/Axltm1Grl,Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002452 abnormal antigen presenting cell physiology "impairment or abnormality of the function of cells involved in making antigen recognizable by lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

 MP:0002933 joint inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the joints" [RGD:Rat Genome Database submission]
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Allelic Composition: Axltm1Grl/Axltm1Grl,Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0003070 increased vascular permeability "greater or faster ability of the blood vessels to permit the passage of substances such as fluid, heat, or gases" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003103 liver degeneration "deterioration of the liver due to injury or disease, often accompanied by loss of function" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91653]
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Allelic Composition: Axltm1Grl/Axltm1Grl,Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0003203 increased neuron apoptosis "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Axltm1Grl/Axltm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0003232 abnormal forebrain development "anomaly in the formation or patterning of the anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [J:93081, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Axltm1Grl/Axltm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0003725 increased autoantibody level "elevated level of antibodies to self-antigens present in the sera; often indicative of autoimmune disease" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: Axltm1Grl/Axltm1Grl,Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0004762 increased anti-double stranded DNA antibody level "increase in the level of antibodies that recognize double stranded DNA" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Axltm1Grl/Axltm1Grl,Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Axltm1Grl/Axltm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Axltm1Grl/Axltm1Grl,Mertktm1Grl/Mertktm1Grl
Genetic Background: involves: C57BL/6J

 MP:0004906 enlarged uterus 
Show

Allelic Composition: Axltm1Grl/Axltm1Grl,Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0005013 increased lymphocyte number "greater than normal white blood cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Axltm1Grl/Axltm1Grl,Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0005048 thrombosis "formation within a tissue or the vascular lumen of a thrombus, an aggregation of coagulated blood containing platelets, fibrin, and entrapped cellular elements " [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Axltm1Grl/Axltm1Grl,Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0005154 increased B cell proliferation "greater than the normal response by B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Axltm1Grl/Axltm1Grl,Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Axltm1Grl/Axltm1Grl,Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Axltm1Grl/Axltm1Grl,Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0006009 abnormal neuronal migration "defective or impaired movement of immature neurons from germinal zones to specific positions where they will reside as they mature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Axltm1Grl/Axltm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Axltm1Grl/Axltm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0008217 abnormal B cell activation "any anomaly in the normal change in morphology and behavior of a mature or immature B cell during an immune response, resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific" [GO:0002312, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Axltm1Grl/Axltm1Grl,Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0008444 retinal cone cell degeneration "a retrogressive impairment of function or destruction of one of the photoreceptor cell types in the retina, in which the photopigment is in invaginations of the cell membrane of the outer segment" [MESH:A08.663.650.650.670.100, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Axltm1Grl/Axltm1Grl,Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0008451 retinal rod cell degeneration "a retrogressive impairment of function or destruction of one of the photoreceptor cell types of the vertebrate retina, in which the photopigment is in stacks of membranous disks separate from the outer cell membrane" [MESH:A08.663.650.650.670.650]
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Allelic Composition: Axltm1Grl/Axltm1Grl,Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0008553 increased circulating tumor necrosis factor level "greater amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Axltm1Grl/Axltm1Grl,Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0009006 prolonged estrous cycle "increase in the length of the sexual cycle of female animals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Axltm1Grl/Axltm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0009008 delayed estrous cycle "onset of the sexual cycle of females occurring at a later than expected day/age" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Axltm1Grl/Axltm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0009012 short diestrus "decrease in the length of the diestrous phase of the estrous cycle in female animals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Axltm1Grl/Axltm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0009014 prolonged proestrus "increase in the length of the proestrous phase of the estrous cycle in female animals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Axltm1Grl/Axltm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0009396 small endometrial glands "decrease in the average size of the simple or branched tubular glands located in the mucous membrane of the uterus" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Axltm1Grl/Axltm1Grl,Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0009853 decreased Sertoli cell phagocytosis "decreased phagocytic activity of testicular Sertoli cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Axltm1Grl/Axltm1Grl,Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Axltm1Grl/Axltm1Grl,Mertktm1Grl/Mertktm1Grl
Genetic Background: involves: C57BL/6J

 MP:0013508 increased granulosa cell apoptosis "increase in the timing or the number of granulsa cells undergoing programmed cell death" [MGI:csmith]
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Allelic Composition: Axltm1Grl/Axltm1Grl,Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000028071 Q9QXK9 / Sh2d2a / SH2 domain containing 2A / Q9NP31*  / reaction / complex
 ENSMUSG00000027646 Src / P05480 / Neuronal proto-onco tyrosine-protein kinase Src / P12931* / SRC proto-oncogene, non-receptor tyrosine kinase*  / reaction / complex
 ENSMUSG00000062960 Kdr / kinase insert domain receptor / P35968*  / complex / reaction
 ENSMUSG00000032462 Pik3cb / Q8BTI9 / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform / P42338* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta*  / complex / reaction
 ENSMUSG00000031834 O08908 / Pik3r2 / Phosphatidylinositol 3-kinase regulatory subunit beta / O00459* / AC007192.1* / phosphoinositide-3-kinase regulatory subunit 2*  / reaction / complex
 ENSMUSG00000041417 P26450 / Pik3r1 / phosphoinositide-3-kinase regulatory subunit 1 / P27986*  / complex / reaction
 ENSMUSG00000023951 Vegfa / Q00731 / vascular endothelial growth factor A / P15692*  / reaction / complex
 ENSMUSG00000027665 P42337 / Pik3ca / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform / P42336* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha*  / complex / reaction






 

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