ENSMUSG00000059089


Mus musculus

Features
Gene ID: ENSMUSG00000059089
  
Biological name :Fcgr4
  
Synonyms : A0A0B4J1G0 / Fcgr4 / Low affinity immunoglobulin gamma Fc region receptor IV
  
Possible biological names infered from orthology : Fc fragment of IgG receptor IIIa / Fc fragment of IgG receptor IIIb / FCGR3A / FCGR3B / O75015 / P08637
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: H3
Gene start: 171018920
Gene end: 171029761
  
Corresponding Affymetrix probe sets: 10351509 (MoGene1.0st)   1425225_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000077873
NCBI entrez gene - 246256     See in Manteia.
MGI - MGI:2179523
RefSeq - NM_144559
RefSeq Peptide - NP_653142
swissprot - A0A0B4J1G0
Ensembl - ENSMUSG00000059089
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FCGR3AENSG00000203747Homo sapiens
 FCGR3BENSG00000162747Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fcgr3 / Mus musculus Fc receptor, IgG, low affinity III (Fcgr3), transcript variant 2, mRNA. / FCGR2C* / P31994* / FCGR2A* / FCGR2B* / P12318* / Fc fragment of IgG receptor IIb* / Fc fragme...ENSMUSG0000005949843
Fcgr1 / P26151 / High affinity immunoglobulin gamma Fc receptor I / Q92637* / FCGR1A* / FCGR1B* / P12314* / Fc fragment of IgG receptor Ib* / Fc fragment of IgG receptor Ia*ENSMUSG0000001594737
Fcgr2b / P31994* / FCGR2A* / FCGR2C* / P12318* / Fc fragment of IgG receptor IIa* / Fc fragment of IgG receptor IIb* / Fc fragment of IgG receptor IIc (gene/pseudogene)*ENSMUSG0000002665636
Fcer1a / P20489 / High affinity immunoglobulin epsilon receptor subunit alpha / P12319* / Fc fragment of IgE receptor Ia*ENSMUSG0000000533933
Fcrlb / Q5DRQ8 / Fc receptor-like B / Q6BAA4*ENSMUSG0000007052428
Fcrl5 / Q68SN8 / Fc receptor-like protein 5 / Q96RD9* / Fc receptor like 5*ENSMUSG0000004803123
Fcrla / Q920A9 / Fc receptor-like A / Q7L513*ENSMUSG0000003842119
FcrlsENSMUSG0000001585214
Fcrl6 / A1YIY0 / Fc receptor-like protein 6 ENSMUSG000000705048
Fcrl1 / Q96LA6* / Fc receptor like 1*ENSMUSG000000599945


Protein motifs (from Interpro)
Interpro ID Name
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013783  Immunoglobulin-like fold
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0038094 Fc-gamma receptor signaling pathway IEA
 biological_processGO:0038095 Fc-epsilon receptor signaling pathway IEA
 biological_processGO:0042060 wound healing IEA
 biological_processGO:0042119 neutrophil activation IMP
 biological_processGO:0045780 positive regulation of bone resorption IMP
 biological_processGO:0051930 regulation of sensory perception of pain IEA
 biological_processGO:0071222 cellular response to lipopolysaccharide IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009897 external side of plasma membrane ISO
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0019767 IgE receptor activity IDA
 molecular_functionGO:0019770 IgG receptor activity IDA
 molecular_functionGO:0019863 IgE binding IEA
 molecular_functionGO:0019864 IgG binding IEA


Pathways (from Reactome)
Pathway description
Post-translational modification: synthesis of GPI-anchored proteins
FCGR activation
Regulation of actin dynamics for phagocytic cup formation
Role of phospholipids in phagocytosis
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002993 arthritis "joint inflammation, marked by changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Egln1tm1.1Fsl/Egln1+
Genetic Background: C57BL/6-Egln1tm1.1Fsl

 MP:0003436 resistance to induced arthritis "less likely to be striken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:75303]
Show

Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Sprntm1Geno/Sprntm1Geno
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J * FVB/N

 MP:0004985 decreased osteoclast cell number "reduced number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Egln1tm1.1Fsl/Egln1+
Genetic Background: C57BL/6-Egln1tm1.1Fsl

 MP:0004993 decreased bone resorption "reduced amount of degradation of the organic and inorganic phases of bone by absorption, usually by the abnormal function or number of osteoclasts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Egln1tm1.1Fsl/Egln1+
Genetic Background: C57BL/6-Egln1tm1.1Fsl

 MP:0005166 decreased susceptiblity to injury "less than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Prnptm1Cwe/Prnptm1Cwe,Sprntm1Geno/Sprntm1Geno
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J * FVB/N

 MP:0005416 abnormal circulating protein level "anomalous blood concentration of any of the macromolecules consisting of long chains of amino acids in peptide linkage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Egln1tm1.1Fsl/Egln1+
Genetic Background: C57BL/6-Egln1tm1.1Fsl

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000002033 Cd3g / P11942 / T-cell surface glycoprotein CD3 gamma chain / P09693* / CD3g molecule*  / complex
 ENSMUSG00000005763 Cd247 / P24161 / T-cell surface glycoprotein CD3 zeta chain / P20963* / CD247 molecule*  / complex
 ENSMUSG00000034116 Vav1 / P27870 / vav 1 oncogene / P15498* / vav guanine nucleotide exchange factor 1*  / reaction / complex
 ENSMUSG00000016933 Plcg1 / Q62077 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 / P19174* / phospholipase C gamma 1*  / complex / reaction
 ENSMUSG00000017776 Crk / Q64010 / Adapter molecule crk / P46108* / CRK proto-oncogene, adaptor protein*  / reaction / complex
 ENSMUSG00000027665 P42337 / Pik3ca / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform / P42336* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha*  / complex / reaction
 ENSMUSG00000032462 Pik3cb / Q8BTI9 / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform / P42338* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta*  / complex / reaction
 ENSMUSG00000041417 P26450 / Pik3r1 / phosphoinositide-3-kinase regulatory subunit 1 / P27986*  / reaction / complex
 ENSMUSG00000031834 O08908 / Pik3r2 / Phosphatidylinositol 3-kinase regulatory subunit beta / O00459* / AC007192.1* / phosphoinositide-3-kinase regulatory subunit 2*  / complex / reaction
 ENSMUSG00000009621 Vav2 / Q60992 / vav 2 oncogene / P52735* / vav guanine nucleotide exchange factor 2*  / reaction / complex
 ENSMUSG00000021457 Syk / P48025 / spleen tyrosine kinase / P43405* / spleen associated tyrosine kinase*  / reaction / complex
 ENSMUSG00000033721 Vav3 / Q9R0C8 / vav 3 oncogene / Q9UKW4* / vav guanine nucleotide exchange factor 3*  / reaction / complex
 ENSMUSG00000041112 Elmo1 / Q8BPU7 / Engulfment and cell motility protein 1 / Q92556* / engulfment and cell motility 1*  / reaction / complex
 ENSMUSG00000017670 Elmo2 / Q8BHL5 / Engulfment and cell motility protein 2 / Q96JJ3* / engulfment and cell motility 2*  / reaction / complex
 ENSMUSG00000058325 Dock1 / Q8BUR4 / Dedicator of cytokinesis protein 1 / Q14185* / dedicator of cytokinesis 1*  / reaction / complex
 ENSMUSG00000034330 Plcg2 / Q8CIH5 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 / P16885* / phospholipase C gamma 2*  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr