ENSG00000203747


Homo sapiens

Features
Gene ID: ENSG00000203747
  
Biological name :FCGR3A
  
Synonyms : Fc fragment of IgG receptor IIIa / FCGR3A / P08637
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: q23.3
Gene start: 161541759
Gene end: 161550737
  
Corresponding Affymetrix probe sets: 204006_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000410180
Ensembl peptide - ENSP00000396567
Ensembl peptide - ENSP00000416607
Ensembl peptide - ENSP00000491631
Ensembl peptide - ENSP00000356944
Ensembl peptide - ENSP00000356946
Ensembl peptide - ENSP00000392047
NCBI entrez gene - 2214     See in Manteia.
OMIM - 146740
RefSeq - XM_011509293
RefSeq - NM_000569
RefSeq - NM_001127592
RefSeq - NM_001127593
RefSeq - NM_001127595
RefSeq - NM_001127596
RefSeq Peptide - NP_001121068
RefSeq Peptide - NP_000560
RefSeq Peptide - NP_001121064
RefSeq Peptide - NP_001121065
RefSeq Peptide - NP_001121067
RefSeq Peptide - NP_001316049
swissprot - P08637
swissprot - A0A1W2PQB1
swissprot - C9JC71
swissprot - H0Y755
swissprot - M9MML0
Ensembl - ENSG00000203747
  
Related genetic diseases (OMIM): 615707 - Immunodeficiency 20, 615707
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Fcgr4ENSMUSG00000059089Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FCGR3B / O75015 / Fc fragment of IgG receptor IIIbENSG0000016274790
FCGR2A / P12318 / Fc fragment of IgG receptor IIaENSG0000014322636
FCGR2C / Fc fragment of IgG receptor IIc (gene/pseudogene)ENSG0000024468234
FCGR2B / P31994 / Fc fragment of IgG receptor IIbENSG0000007269434
FCGR1A / P12314 / Fc fragment of IgG receptor IaENSG0000015033733
FCGR1B / Q92637 / Fc fragment of IgG receptor IbENSG0000019801932
FCER1A / P12319 / Fc fragment of IgE receptor IaENSG0000017963931
FCRL5 / Q96RD9 / Fc receptor like 5ENSG0000014329727
FCRLB / Q6BAA4 / Fc receptor like BENSG0000016274626
FCRL3 / Q96P31 / Fc receptor like 3ENSG0000016085622
FCRL4 / Q96PJ5 / Fc receptor like 4ENSG0000016351822
FCRLA / Q7L513 / Fc receptor like AENSG0000013218519
FCRL2 / Q96LA5 / Fc receptor like 2ENSG0000013270417
FCRL6 / Q6DN72 / Fc receptor like 6ENSG0000018103615
FCRL1 / Q96LA6 / Fc receptor like 1ENSG000001635347


Protein motifs (from Interpro)
Interpro ID Name
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013783  Immunoglobulin-like fold
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006955 immune response TAS
 biological_processGO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS
 biological_processGO:0050776 regulation of immune response TAS
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0019864 IgG binding IEA


Pathways (from Reactome)
Pathway description
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
FCGR activation
Regulation of actin dynamics for phagocytic cup formation
Role of phospholipids in phagocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000007 Autosomal recessive inheritance "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in homozygotes. In the context of medical genetics, autosomal recessive disorders manifest in homozygotes (with two copies of the mutant allele) or compound heterozygotes (whereby each copy of a gene has a distinct mutant allele)." [HPO:curators]
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 HP:0000403 Recurrent otitis media 
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 HP:0002721 Immunodeficiency 
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 HP:0011108 Recurrent sinusitis "A `recurrent` (PATO:0000427) form of `sinusitis` (HP:0000246)." [HPO:probinson]
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000160654 CD3G / P09693 / CD3g molecule  / complex
 ENSG00000198821 CD247 / P20963 / CD247 molecule  / complex
 ENSG00000197943 PLCG2 / P16885 / phospholipase C gamma 2  / complex / reaction
 ENSG00000155849 ELMO1 / Q92556 / engulfment and cell motility 1  / complex / reaction
 ENSG00000167193 CRK / P46108 / CRK proto-oncogene, adaptor protein  / reaction / complex
 ENSG00000051382 P42338 / PIK3CB / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta  / complex / reaction
 ENSG00000145675 P27986 / PIK3R1 / phosphoinositide-3-kinase regulatory subunit 1  / complex / reaction
 ENSG00000062598 ELMO2 / Q96JJ3 / engulfment and cell motility 2  / reaction / complex
 ENSG00000211896 IGHG1 / P01857 / immunoglobulin heavy constant gamma 1 (G1m marker)  / complex / reaction
 ENSG00000124181 PLCG1 / P19174 / phospholipase C gamma 1  / reaction / complex
 ENSG00000211892 IGHG4 / P01861 / immunoglobulin heavy constant gamma 4 (G4m marker)  / complex / reaction
 ENSG00000150760 DOCK1 / Q14185 / dedicator of cytokinesis 1  / reaction / complex
 ENSG00000121879 P42336 / PIK3CA / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha  / reaction / complex
 ENSG00000105647 O00459 / PIK3R2 / phosphoinositide-3-kinase regulatory subunit 2  / complex / reaction
 ENSG00000141968 VAV1 / P15498 / vav guanine nucleotide exchange factor 1  / reaction / complex
 ENSG00000211893 IGHG2 / P01859 / immunoglobulin heavy constant gamma 2 (G2m marker)  / complex / reaction
 ENSG00000165025 SYK / P43405 / spleen associated tyrosine kinase  / complex / reaction
 ENSG00000160293 VAV2 / P52735 / vav guanine nucleotide exchange factor 2  / complex / reaction
 ENSG00000134215 VAV3 / Q9UKW4 / vav guanine nucleotide exchange factor 3  / reaction / complex






 

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