ENSG00000150337


Homo sapiens

Features
Gene ID: ENSG00000150337
  
Biological name :FCGR1A
  
Synonyms : Fc fragment of IgG receptor Ia / FCGR1A / P12314
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: q21.2
Gene start: 149782671
Gene end: 149792518
  
Corresponding Affymetrix probe sets: 214511_x_at (Human Genome U133 Plus 2.0 Array)   216950_s_at (Human Genome U133 Plus 2.0 Array)   216951_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000394279
Ensembl peptide - ENSP00000358165
NCBI entrez gene - 2209     See in Manteia.
OMIM - 146760
RefSeq - XM_005244958
RefSeq - NM_000566
RefSeq - XM_005244957
RefSeq Peptide - NP_000557
swissprot - P12314
swissprot - C9JSN8
Ensembl - ENSG00000150337
  
Related genetic diseases (OMIM): 146760 - [IgG receptor I, phagocytic, familial deficiency of]
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Fcgr1ENSMUSG00000015947Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FCGR1B / Q92637 / Fc fragment of IgG receptor IbENSG0000019801974
FCRLB / Q6BAA4 / Fc receptor like BENSG0000016274632
FCRL3 / Q96P31 / Fc receptor like 3ENSG0000016085629
FCRL4 / Q96PJ5 / Fc receptor like 4ENSG0000016351829
FCRL5 / Q96RD9 / Fc receptor like 5ENSG0000014329729
FCRLA / Q7L513 / Fc receptor like AENSG0000013218528
FCGR3B / O75015 / Fc fragment of IgG receptor IIIbENSG0000016274725
FCGR3A / P08637 / Fc fragment of IgG receptor IIIaENSG0000020374725
FCGR2A / P12318 / Fc fragment of IgG receptor IIaENSG0000014322624
FCGR2C / Fc fragment of IgG receptor IIc (gene/pseudogene)ENSG0000024468224
FCGR2B / P31994 / Fc fragment of IgG receptor IIbENSG0000007269424
FCRL6 / Q6DN72 / Fc receptor like 6ENSG0000018103623
FCER1A / P12319 / Fc fragment of IgE receptor IaENSG0000017963923
FCRL2 / Q96LA5 / Fc receptor like 2ENSG0000013270420
FCRL1 / Q96LA6 / Fc receptor like 1ENSG0000016353414


Protein motifs (from Interpro)
Interpro ID Name
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013151  Immunoglobulin
 IPR013783  Immunoglobulin-like fold
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS
 biological_processGO:0006898 receptor-mediated endocytosis TAS
 biological_processGO:0006911 phagocytosis, engulfment TAS
 biological_processGO:0006955 immune response TAS
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0050776 regulation of immune response TAS
 biological_processGO:0060333 interferon-gamma-mediated signaling pathway TAS
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030669 clathrin-coated endocytic vesicle membrane TAS
 cellular_componentGO:0031901 early endosome membrane TAS
 molecular_functionGO:0005057 obsolete signal transducer activity, downstream of receptor TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019864 IgG binding IEA


Pathways (from Reactome)
Pathway description
Cross-presentation of soluble exogenous antigens (endosomes)
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
FCGR activation
Regulation of actin dynamics for phagocytic cup formation
Role of phospholipids in phagocytosis
Interferon gamma signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000188211 Q68D85 / NCR3LG1 / natural killer cell cytotoxicity receptor 3 ligand 1  / reaction / complex
 ENSG00000062598 ELMO2 / Q96JJ3 / engulfment and cell motility 2  / reaction / complex
 ENSG00000160293 VAV2 / P52735 / vav guanine nucleotide exchange factor 2  / reaction / complex
 ENSG00000141968 VAV1 / P15498 / vav guanine nucleotide exchange factor 1  / complex / reaction
 ENSG00000105647 O00459 / PIK3R2 / phosphoinositide-3-kinase regulatory subunit 2  / reaction / complex
 ENSG00000198821 CD247 / P20963 / CD247 molecule  / complex
 ENSG00000211893 IGHG2 / P01859 / immunoglobulin heavy constant gamma 2 (G2m marker)  / complex / reaction
 ENSG00000150760 DOCK1 / Q14185 / dedicator of cytokinesis 1  / complex / reaction
 ENSG00000051382 P42338 / PIK3CB / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta  / reaction / complex
 ENSG00000121879 P42336 / PIK3CA / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha  / complex / reaction
 ENSG00000204475 NCR3 / O14931 / natural cytotoxicity triggering receptor 3  / complex
 ENSG00000134215 VAV3 / Q9UKW4 / vav guanine nucleotide exchange factor 3  / reaction / complex
 ENSG00000189430 NCR1 / O76036 / natural cytotoxicity triggering receptor 1  / complex
 ENSG00000165025 SYK / P43405 / spleen associated tyrosine kinase  / reaction / complex
 ENSG00000167193 CRK / P46108 / CRK proto-oncogene, adaptor protein  / reaction / complex
 ENSG00000155849 ELMO1 / Q92556 / engulfment and cell motility 1  / reaction / complex
 ENSG00000124181 PLCG1 / P19174 / phospholipase C gamma 1  / complex / reaction
 ENSG00000211892 IGHG4 / P01861 / immunoglobulin heavy constant gamma 4 (G4m marker)  / reaction / complex
 ENSG00000197943 PLCG2 / P16885 / phospholipase C gamma 2  / reaction / complex
 ENSG00000160654 CD3G / P09693 / CD3g molecule  / complex
 ENSG00000211896 IGHG1 / P01857 / immunoglobulin heavy constant gamma 1 (G1m marker)  / reaction / complex
 ENSG00000145675 P27986 / PIK3R1 / phosphoinositide-3-kinase regulatory subunit 1  / complex / reaction






 

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