ENSG00000204475


Homo sapiens

Features
Gene ID: ENSG00000204475
  
Biological name :NCR3
  
Synonyms : natural cytotoxicity triggering receptor 3 / NCR3 / O14931
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: -1
Band: p21.33
Gene start: 31588895
Gene end: 31592985
  
Corresponding Affymetrix probe sets: 210763_x_at (Human Genome U133 Plus 2.0 Array)   211010_s_at (Human Genome U133 Plus 2.0 Array)   211583_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000342156
Ensembl peptide - ENSP00000365239
Ensembl peptide - ENSP00000365240
Ensembl peptide - ENSP00000365241
NCBI entrez gene - 259197     See in Manteia.
OMIM - 611550
RefSeq - XM_011514459
RefSeq - NM_001145466
RefSeq - NM_001145467
RefSeq - NM_147130
RefSeq - XM_006715049
RefSeq Peptide - NP_667341
RefSeq Peptide - NP_001138938
RefSeq Peptide - NP_001138939
swissprot - O14931
swissprot - Q05D23
Ensembl - ENSG00000204475
  
Related genetic diseases (OMIM): 609148 - {Malaria, mild, susceptibility to}, 609148
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
No match


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013106  Immunoglobulin V-set domain
 IPR013783  Immunoglobulin-like fold
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002429 immune response-activating cell surface receptor signaling pathway IDA
 biological_processGO:0002860 positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target IBA
 biological_processGO:0006954 inflammatory response NAS
 biological_processGO:0006955 immune response NAS
 biological_processGO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IBA
 biological_processGO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IBA
 biological_processGO:0008037 cell recognition TAS
 biological_processGO:0030101 natural killer cell activation IDA
 biological_processGO:0042271 susceptibility to natural killer cell mediated cytotoxicity IBA
 biological_processGO:0045954 positive regulation of natural killer cell mediated cytotoxicity IMP
 biological_processGO:0050776 regulation of immune response TAS
 biological_processGO:0060370 susceptibility to T cell mediated cytotoxicity IBA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0005913 cell-cell adherens junction IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005102 signaling receptor binding IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IBA
 molecular_functionGO:0050839 cell adhesion molecule binding IBA


Pathways (from Reactome)
Pathway description
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000188211 Q68D85 / NCR3LG1 / natural killer cell cytotoxicity receptor 3 ligand 1  / complex / reaction
 ENSG00000198821 CD247 / P20963 / CD247 molecule  / complex
 ENSG00000150337 FCGR1A / P12314 / Fc fragment of IgG receptor Ia  / complex






 

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