ENSMUSG00000015947


Mus musculus

Features
Gene ID: ENSMUSG00000015947
  
Biological name :Fcgr1
  
Synonyms : Fcgr1 / High affinity immunoglobulin gamma Fc receptor I / P26151
  
Possible biological names infered from orthology : Fc fragment of IgG receptor Ia / Fc fragment of IgG receptor Ib / FCGR1A / FCGR1B / P12314 / Q92637
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: F2.1
Gene start: 96282909
Gene end: 96293969
  
Corresponding Affymetrix probe sets: 10500335 (MoGene1.0st)   1417876_at (Mouse Genome 430 2.0 Array)   1436625_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000142661
Ensembl peptide - ENSMUSP00000029748
NCBI entrez gene - 14129     See in Manteia.
MGI - MGI:95498
RefSeq - NM_010186
RefSeq Peptide - NP_034316
swissprot - A0A0G2JE74
swissprot - P26151
Ensembl - ENSMUSG00000015947
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FCGR1AENSG00000150337Homo sapiens
 FCGR1BENSG00000198019Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fcrlb / Q5DRQ8 / Fc receptor-like B / Q6BAA4*ENSMUSG0000007052429
Fcrl5 / Q68SN8 / Fc receptor-like protein 5 / Q96RD9* / Fc receptor like 5*ENSMUSG0000004803126
Fcrla / Q920A9 / Fc receptor-like A / Q7L513*ENSMUSG0000003842124
Fcgr2b / P31994* / FCGR2A* / FCGR2C* / P12318* / Fc fragment of IgG receptor IIa* / Fc fragment of IgG receptor IIb* / Fc fragment of IgG receptor IIc (gene/pseudogene)*ENSMUSG0000002665624
Fcgr3 / Mus musculus Fc receptor, IgG, low affinity III (Fcgr3), transcript variant 2, mRNA. / FCGR2C* / P31994* / FCGR2A* / FCGR2B* / P12318* / Fc fragment of IgG receptor IIb* / Fc fragme...ENSMUSG0000005949824
Fcgr4 / A0A0B4J1G0 / Low affinity immunoglobulin gamma Fc region receptor IV / P08637* / FCGR3A* / FCGR3B* / O75015* / Fc fragment of IgG receptor IIIa* / Fc fragment of IgG receptor IIIb*ENSMUSG0000005908923
Fcer1a / P20489 / High affinity immunoglobulin epsilon receptor subunit alpha / P12319* / Fc fragment of IgE receptor Ia*ENSMUSG0000000533921
FcrlsENSMUSG0000001585218
Fcrl6 / A1YIY0 / Fc receptor-like protein 6 ENSMUSG000000705047
Fcrl1 / Q96LA6* / Fc receptor like 1*ENSMUSG000000599945


Protein motifs (from Interpro)
Interpro ID Name
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013151  Immunoglobulin
 IPR013783  Immunoglobulin-like fold
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001788 antibody-dependent cellular cytotoxicity IMP
 biological_processGO:0001798 positive regulation of type IIa hypersensitivity IMP
 biological_processGO:0001805 positive regulation of type III hypersensitivity IMP
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006898 receptor-mediated endocytosis IMP
 biological_processGO:0006910 phagocytosis, recognition IMP
 biological_processGO:0006911 phagocytosis, engulfment IMP
 biological_processGO:0007166 cell surface receptor signaling pathway IMP
 biological_processGO:0009617 response to bacterium IMP
 biological_processGO:0019884 antigen processing and presentation of exogenous antigen IMP
 biological_processGO:0038094 Fc-gamma receptor signaling pathway IEA
 biological_processGO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I IMP
 biological_processGO:0042742 defense response to bacterium IMP
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0050766 positive regulation of phagocytosis IMP
 biological_processGO:0050776 regulation of immune response IMP
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0019770 IgG receptor activity IMP
 molecular_functionGO:0019864 IgG binding IMP


Pathways (from Reactome)
Pathway description
Cross-presentation of soluble exogenous antigens (endosomes)
FCGR activation
Regulation of actin dynamics for phagocytic cup formation
Role of phospholipids in phagocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001798 impaired macrophage phagocytosis "reduced ability of these phagocytic cells to internalize particulate matter" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fcgr1tm1Jsv/Fcgr1tm1Jsv,Fcgr2btm1Ttk/Fcgr2btm1Ttk,Fcgr3tm1Jsv/Fcgr3tm1Jsv
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/c * C57BL/6

Allelic Composition: Fcgr1tm1Hoga/Fcgr1tm1Hoga
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001876 decreased inflammatory response "less than expected response to injury, infection, or insult" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Krt71rco3/Krt71rco3
Genetic Background: C3HeB/FeJ-Krt71rco3

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lama1tm1.1Arhi/Lama1tm1.2Arhi,Edil3Tg(Sox2-cre)1Amc/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Baxtm1Sjk/Baxtm1Sjk
Genetic Background: involves: 129X1/SvJ

 MP:0002421 abnormal cell-mediated immunity "abnormal function of any adaptive immune response in which T cells play a main role " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Krt71rco3/Krt71rco3
Genetic Background: C3HeB/FeJ-Krt71rco3

 MP:0002423 abnormal mast cell physiology "anomalous response of the granulated cells found in most tissues and which contain large amounts of histamine and heparin in granules" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Fcer1atm1Knt/Fcer1atm1Knt,Fcer2atm1Max/Fcer2atm1Max,Fcgr1tm1Jsv/Fcgr1tm1Jsv,Fcgr2btm1Ttk/Fcgr2btm1Ttk,Fcgr3tm1Jsv/Fcgr3tm1Jsv
Genetic Background: B6.Cg-Fcgr2btm1Ttk Fcgr3tm1Jsv Fcer1atm1Knt Fcgr1tm1Jsv Fcer2atm1Max

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Baxtm1Sjk/Baxtm1Sjk
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Fcer1atm1Knt/Fcer1atm1Knt,Fcer2atm1Max/Fcer2atm1Max,Fcgr1tm1Jsv/Fcgr1tm1Jsv,Fcgr2btm1Ttk/Fcgr2btm1Ttk,Fcgr3tm1Jsv/Fcgr3tm1Jsv
Genetic Background: B6.Cg-Fcgr2btm1Ttk Fcgr3tm1Jsv Fcer1atm1Knt Fcgr1tm1Jsv Fcer2atm1Max

 MP:0002454 abnormal macrophage antigen presentation "impairment of these phagocytic cells to process and present antigen to T lymphocytes" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Krt71rco3/Krt71rco3
Genetic Background: C3HeB/FeJ-Krt71rco3

 MP:0002455 abnormal dendritic cell antigen presentation "impairment of these specialized cells to process and present antigen to T lymphoytes" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Baxtm1Sjk/Baxtm1Sjk
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Fcgr1tm1Jgjw/Fcgr1tm1Jgjw
Genetic Background: involves: 129 * C57BL/6

 MP:0002493 increased IgG "greater than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fcgr1tm1Hoga/Fcgr1tm1Hoga
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002531 type I hypersensitivity reaction "a reaction manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized; it is IgE-mediated, and mast cell activation and degranulation are hallmarks" [Pathology , 2nd edition:ISBN 0-397-51047-0]
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Allelic Composition: Baxtm1Sjk/Baxtm1Sjk
Genetic Background: involves: 129X1/SvJ

 MP:0003436 resistance to induced arthritis "less likely to be striken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:75303]
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Allelic Composition: Baxtm1Sjk/Baxtm1Sjk
Genetic Background: involves: 129X1/SvJ

 MP:0004828 decreased susceptibility to autoimmune hemolytic anemia "reduced likelihood that an organism will develop an abnormality of the immune system that destroys red blood cells (hemolysis) prematurely" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Baxtm1Sjk/Baxtm1Sjk
Genetic Background: involves: 129X1/SvJ

 MP:0005596 increased susceptibility to type I hypersensitvity reaction "greater likelihood of developing a response manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized; it is IgE-mediated, and mast cell activation and degranulation are hallmarks" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fcer1atm1Knt/Fcer1atm1Knt,Fcer2atm1Max/Fcer2atm1Max,Fcgr1tm1Jsv/Fcgr1tm1Jsv,Fcgr2btm1Ttk/Fcgr2btm1Ttk,Fcgr3tm1Jsv/Fcgr3tm1Jsv
Genetic Background: B6.Cg-Fcgr2btm1Ttk Fcgr3tm1Jsv Fcer1atm1Knt Fcgr1tm1Jsv Fcer2atm1Max

 MP:0008115 abnormal dendritic cell differentiation "atypical production of or inability to produce a cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fcgr1tm1Jgjw/Fcgr1tm1Jgjw
Genetic Background: involves: 129 * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000034116 Vav1 / P27870 / vav 1 oncogene / P15498* / vav guanine nucleotide exchange factor 1*  / complex / reaction
 ENSMUSG00000016933 Plcg1 / Q62077 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 / P19174* / phospholipase C gamma 1*  / reaction / complex
 ENSMUSG00000017776 Crk / Q64010 / Adapter molecule crk / P46108* / CRK proto-oncogene, adaptor protein*  / complex / reaction
 ENSMUSG00000021457 Syk / P48025 / spleen tyrosine kinase / P43405* / spleen associated tyrosine kinase*  / complex / reaction
 ENSMUSG00000002033 Cd3g / P11942 / T-cell surface glycoprotein CD3 gamma chain / P09693* / CD3g molecule*  / complex
 ENSMUSG00000027665 P42337 / Pik3ca / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform / P42336* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha*  / reaction / complex
 ENSMUSG00000032462 Pik3cb / Q8BTI9 / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform / P42338* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta*  / complex / reaction
 ENSMUSG00000041417 P26450 / Pik3r1 / phosphoinositide-3-kinase regulatory subunit 1 / P27986*  / complex / reaction
 ENSMUSG00000031834 O08908 / Pik3r2 / Phosphatidylinositol 3-kinase regulatory subunit beta / O00459* / AC007192.1* / phosphoinositide-3-kinase regulatory subunit 2*  / complex / reaction
 ENSMUSG00000009621 Vav2 / Q60992 / vav 2 oncogene / P52735* / vav guanine nucleotide exchange factor 2*  / complex / reaction
 ENSMUSG00000033721 Vav3 / Q9R0C8 / vav 3 oncogene / Q9UKW4* / vav guanine nucleotide exchange factor 3*  / complex / reaction
 ENSMUSG00000041112 Elmo1 / Q8BPU7 / Engulfment and cell motility protein 1 / Q92556* / engulfment and cell motility 1*  / complex / reaction
 ENSMUSG00000017670 Elmo2 / Q8BHL5 / Engulfment and cell motility protein 2 / Q96JJ3* / engulfment and cell motility 2*  / reaction / complex
 ENSMUSG00000058325 Dock1 / Q8BUR4 / Dedicator of cytokinesis protein 1 / Q14185* / dedicator of cytokinesis 1*  / reaction / complex
 ENSMUSG00000034330 Plcg2 / Q8CIH5 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 / P16885* / phospholipase C gamma 2*  / complex / reaction






 

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