ENSMUSG00000034330


Mus musculus

Features
Gene ID: ENSMUSG00000034330
  
Biological name :Plcg2
  
Synonyms : 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 / Plcg2 / Q8CIH5
  
Possible biological names infered from orthology : P16885 / phospholipase C gamma 2
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: E1
Gene start: 117498291
Gene end: 117635142
  
Corresponding Affymetrix probe sets: 10575799 (MoGene1.0st)   1426926_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000079991
NCBI entrez gene - 234779     See in Manteia.
MGI - MGI:97616
RefSeq - NM_172285
RefSeq Peptide - NP_758489
swissprot - Q8CIH5
Ensembl - ENSMUSG00000034330
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 plcg2ENSDARG00000068763Danio rerio
 PLCG2ENSGALG00000033507Gallus gallus
 PLCG2ENSG00000197943Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Plcg1 / Q62077 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 / P19174* / phospholipase C gamma 1*ENSMUSG0000001693350
Plce1 / Q8K4S1 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 / Q9P212* / phospholipase C epsilon 1*ENSMUSG0000002499822


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR000909  Phosphatidylinositol-specific phospholipase C, X domain
 IPR000980  SH2 domain
 IPR001192  Phosphoinositide phospholipase C family
 IPR001452  SH3 domain
 IPR001711  Phospholipase C, phosphatidylinositol-specific, Y domain
 IPR001849  Pleckstrin homology domain
 IPR011992  EF-hand domain pair
 IPR011993  PH-like domain superfamily
 IPR016279  Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma
 IPR017946  PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily
 IPR028381  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
 IPR035023  PLC-gamma, C-terminal SH2 domain
 IPR035024  PLC-gamma, N-terminal SH2 domain
 IPR035723  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2, SH3 domain
 IPR035892  C2 domain superfamily
 IPR036028  SH3-like domain superfamily
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002092 positive regulation of receptor internalization IMP
 biological_processGO:0002316 follicular B cell differentiation IMP
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006661 phosphatidylinositol biosynthetic process IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0009395 phospholipid catabolic process IEA
 biological_processGO:0010468 regulation of gene expression IMP
 biological_processGO:0016042 lipid catabolic process IEA
 biological_processGO:0030183 B cell differentiation IMP
 biological_processGO:0032237 activation of store-operated calcium channel activity IMP
 biological_processGO:0032481 positive regulation of type I interferon production IMP
 biological_processGO:0032496 response to lipopolysaccharide IDA
 biological_processGO:0032959 inositol trisphosphate biosynthetic process IDA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0043069 negative regulation of programmed cell death IMP
 biological_processGO:0050852 T cell receptor signaling pathway IDA
 biological_processGO:0050853 B cell receptor signaling pathway IMP
 biological_processGO:0051209 release of sequestered calcium ion into cytosol IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IEA
 molecular_functionGO:0001784 phosphotyrosine residue binding IEA
 molecular_functionGO:0004435 phosphatidylinositol phospholipase C activity ISO
 molecular_functionGO:0004629 phospholipase C activity TAS
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008081 phosphoric diester hydrolase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
GPVI-mediated activation cascade
Toll Like Receptor 4 (TLR4) Cascade
Synthesis of IP3 and IP4 in the cytosol
Role of phospholipids in phagocytosis
DAP12 signaling
FCERI mediated MAPK activation
FCERI mediated Ca+2 mobilization
CLEC7A (Dectin-1) signaling
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000130 abnormal cancellous bone morphology "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ctla4tm1All/Ctla4tm1All
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000574 abnormal foot pad morphology "anomalous structure of the body of fat on the foot" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Myf5tm3(cre)Sor/Myf5+,Stat5btm1Mam/Stat5btm1Mam,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * FVB/N

 MP:0000693 spleen hyperplasia "increased cell number in the spleen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
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Allelic Composition: Oca2p/Oca2p
Genetic Background: Not Specified

 MP:0000694 spleen hypoplasia "small size due to reduced cell number in the spleen" [J:43971]
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Allelic Composition: Blnktm1Kplm/Blnktm1Kplm,Plcg2tm1.1Kuro/Plcg2tm1.1Kuro
Genetic Background: involves: 129P2/OlaHsd

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Plcg2tm1Jni/Plcg2tm1Jni,Tg(IghMyc)22Bri/0
Genetic Background: involves: 129P2/OlaHsd * C57BL * C57BL/6 * SJL

 MP:0001194 dermatitis "inflammation of the skin" [J:65146]
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Allelic Composition: Arhgap6/Hccs/Mid1tm1Hzo/Y
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Plcg2Ali5/Plcg2+,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S7/SvEvBrd * C3HeB/FeJ * C3HeB/FeJ-Plcg2Ali5

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Plcg2tm1Jni/Plcg2tm1Jni
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001634 internal hemorrhage "blood loss in the interior of the body due to vessel rupture or dysmorphology " [J:23170]
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Allelic Composition: Bdnftm1Par/Bdnf+,Ntrk2tm1.1Tes/Ntrk2+
Genetic Background: B6.129S1-Bdnftm1Par Ntrk2tm1.1Tes

Allelic Composition: Plcg2al/Plcg2al
Genetic Background: involves: 129 * C57BL/6

 MP:0001800 abnormal humoral immune response "abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Clnktm1Rygo/Clnktm1Rygo
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0001802 arrested B cell development "inability to produce mature B cells, and accumulation of B cell precursors" [J:52607]
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Allelic Composition: Plcg2tm1Jni/Plcg2tm1Jni
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Pik3r1tm1Dfr/Pik3r1tm1Dfr,Plcg2tm1Jni/Plcg2tm1Jni
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0001806 decreased IgM "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il4/Il13tm3Anjm/Il4/Il13tm3Anjm
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Plcg2m1Btlr/Plcg2m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0001845 abnormal inflammatory response "aberrant reaction of the microcirculation characterized by movement of fluid and leukocytes from the blood into extravascular tissues" [Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Myf5tm3(cre)Sor/Myf5+,Stat5btm1Mam/Stat5btm1Mam,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * FVB/N

 MP:0001879 abnormal lymphatic vessel morphology "malformation of the network of vessels which carries lymph around the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Bdnftm1Par/Bdnf+,Ntrk2tm1.1Tes/Ntrk2+
Genetic Background: B6.129S1-Bdnftm1Par Ntrk2tm1.1Tes

Allelic Composition: Plcg2al/Plcg2al
Genetic Background: involves: 129 * C57BL/6

 MP:0002023 B cell derived lymphoma "heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Plcg2tm1Jni/Plcg2tm1Jni,Tg(IghMyc)22Bri/0
Genetic Background: involves: 129P2/OlaHsd * C57BL * C57BL/6 * SJL

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bdnftm1Par/Bdnf+,Ntrk2tm1.1Tes/Ntrk2+
Genetic Background: B6.129S1-Bdnftm1Par Ntrk2tm1.1Tes

Allelic Composition: Plcg2al/Plcg2al
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Plcg2tm1Jni/Plcg2tm1Jni,Tg(IghMyc)22Bri/0
Genetic Background: involves: 129P2/OlaHsd * C57BL * C57BL/6 * SJL

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Oca2p/Oca2p
Genetic Background: Not Specified

Allelic Composition: Plcg2tm1Jni/Plcg2tm1Jni
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Pik3r1tm1Dfr/Pik3r1tm1Dfr,Plcg2tm1Jni/Plcg2tm1Jni
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

Allelic Composition: Plcg2m1Btlr/Plcg2m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0002376 abnormal dendritic cell physiology "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]
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Allelic Composition: Plcg2tm1Jni/Plcg2tm1Jni
Genetic Background: involves: 129P2/OlaHsd

 MP:0002418 increased susceptibility to viral infection "greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Plcg2tm1Jni/Plcg2tm1Jni
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Arhgap6/Hccs/Mid1tm1Hzo/Y
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Plcg2Ali5/Plcg2+
Genetic Background: involves: C57BL/6J * C3HeB/FeJ-Plcg2Ali5

Allelic Composition: Plcg2Ali5/Plcg2Ali5
Genetic Background: involves: C57BL/6J * C3HeB/FeJ-Plcg2Ali5

Allelic Composition: Plcg2tm1Jni/Plcg2tm1Jni
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Plcg2tm1Jni/Plcg2tm1Jni
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002499 chronic inflammation "persistent inflammatory response, often caused by persistent infection or during an autoimmune response" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Arhgap6/Hccs/Mid1tm1Hzo/Y
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Plcg2Ali5/Plcg2Ali5
Genetic Background: involves: C57BL/6J * C3HeB/FeJ-Plcg2Ali5

Allelic Composition: Plcg2Ali5/Plcg2+,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S7/SvEvBrd * C3HeB/FeJ * C3HeB/FeJ-Plcg2Ali5

 MP:0002743 glomerulonephritis "glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Plcg2Ali5/Plcg2+
Genetic Background: involves: C57BL/6J * C3HeB/FeJ-Plcg2Ali5

Allelic Composition: Plcg2Ali5/Plcg2Ali5
Genetic Background: involves: C57BL/6J * C3HeB/FeJ-Plcg2Ali5

 MP:0003132 increased number of pre-B cells "greater number of progenitor cells that form the B cell component of the immune system" [J:91592, Immunobiology, The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Plcg2tm1Jni/Plcg2tm1Jni
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003436 resistance to induced arthritis "less likely to be striken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:75303]
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Allelic Composition: Plcg2tm1Jni/Plcg2tm1Jni
Genetic Background: involves: 129P2/OlaHsd

 MP:0003560 osteoarthritis "a type of arthritis that is caused by the breakdown and eventual loss of the cartilage of one or more joints" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95374]
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Allelic Composition: Arhgap6/Hccs/Mid1tm1Hzo/Y
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Plcg2Ali5/Plcg2+,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: involves: 129S7/SvEvBrd * C3HeB/FeJ * C3HeB/FeJ-Plcg2Ali5

 MP:0004985 decreased osteoclast cell number "reduced number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Plcg2tm1Jni/Plcg2tm1Jni
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Blnktm1Kplm/Blnktm1Kplm,Plcg2tm1.1Kuro/Plcg2tm1.1Kuro
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Blnktm1Kplm/Blnktm1Kplm,Plcg2tm1.1Kuro/Plcg2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0005070 defective NK cell cytolysis "impaired ability of these cells to destroy or dissolve targeted cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:6213]
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Allelic Composition: Clnktm1Rygo/Clnktm1Rygo
Genetic Background: B6.129P2-Clnktm1Rygo

Allelic Composition: Plcg2tm1Jni/Plcg2tm1Jni
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005093 impaired B cell proliferation "absent or reduced ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Clnktm1Rygo/Clnktm1Rygo
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Plcg2tm1Jni/Plcg2tm1Jni
Genetic Background: involves: 129P2/OlaHsd

 MP:0005154 increased B cell proliferation "greater than the normal response by B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Plcg2tm1Jni/Plcg2tm1Jni
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005461 abnormal dendritic cell morphology/development "anomalous structure or atypical formation of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Plcg2tm1Jni/Plcg2tm1Jni
Genetic Background: involves: 129P2/OlaHsd

 MP:0008167 increased B-1a cell number "greater number of the B-1 B cell subset bearing the CD5 surface marker" [CL:0000820, PMID:11861604]
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Allelic Composition: Clnktm1Rygo/Clnktm1Rygo
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Ightm1.1Twin/Ightm1.1Twin,Plcg2Ali5/Plcg2+
Genetic Background: involves: 129 * 129S4/SvJae * C3HeB/FeJ * C57BL/6

 MP:0008174 decreased follicular B cell number "reduced number of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Plcg2tm1Jni/Plcg2tm1Jni
Genetic Background: involves: 129P2/OlaHsd

 MP:0008186 increased pro-B cell number "greater number of the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs" [CL:0000826, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Clnktm1Rygo/Clnktm1Rygo
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Plcg2tm1Jni/Plcg2tm1Jni
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Plcg2tm1.1Kuro/Plcg2tm1.1Kuro
Genetic Background: Not Specified

 MP:0008190 decreased transitional stage B cell number "reduced number of immature B cells of an intermediate stage between the pre-B cell stage and the mature naive stage; transitional B cells express surface immunoglobulin, and are subject to the process of B cell selection" [CL:0000818, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Plcg2Ali5/Plcg2Ali5
Genetic Background: involves: C57BL/6J * C3HeB/FeJ-Plcg2Ali5

 MP:0008207 decreased B-2 cell number "reduced number of conventional B cells subject to antigenic stimulation and dependent on T cell help and with a distinct surface marker expression pattern from B-1 B cells" [CL:0000822, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:11861604]
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Allelic Composition: Arhgap6/Hccs/Mid1tm1Hzo/Y
Genetic Background: involves: 129S7/SvEvBrd

 MP:0008209 decreased pre-B cell number "reduced number of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Clnktm1Rygo/Clnktm1Rygo
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Pik3r1tm1Dfr/Pik3r1tm1Dfr,Plcg2tm1Jni/Plcg2tm1Jni
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0008211 decreased mature B cell number "reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
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Allelic Composition: Plcg2Ali5/Plcg2Ali5
Genetic Background: involves: C57BL/6J * C3HeB/FeJ-Plcg2Ali5

Allelic Composition: Plcg2tm1Kuro/Plcg2tm1Kuro,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Plcg2tm1Jni/Plcg2tm1Jni
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Pik3r1tm1Dfr/Pik3r1tm1Dfr,Plcg2tm1Jni/Plcg2tm1Jni
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0008214 increased immature B cell number "greater number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Plcg2tm1Kuro/Plcg2tm1Kuro,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0008215 decreased immature B cell number "reduced number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pik3r1tm1Dfr/Pik3r1tm1Dfr,Plcg2tm1Jni/Plcg2tm1Jni
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0008217 abnormal B cell activation "any anomaly in the normal change in morphology and behavior of a mature or immature B cell during an immune response, resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific" [GO:0002312, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Blnktm1Kplm/Blnktm1Kplm,Plcg2tm1.1Kuro/Plcg2+
Genetic Background: involves: 129P2/OlaHsd

 MP:0008396 abnormal osteoclast differentiation "atypical production of or inability to produce bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Plcg2tm1Jni/Plcg2tm1Jni
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008561 decreased tumor necrosis factor secretion "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Zfp318M1Btlr/Zfp318+
Genetic Background: C57BL/6J-Zfp318M1Btlr

Allelic Composition: Plcg2M2Btlr/Plcg2+
Genetic Background: C57BL/6J-Plcg2M2Btlr

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Clnktm1Rygo/Clnktm1Rygo
Genetic Background: B6.129P2-Clnktm1Rygo

Allelic Composition: Plcg2tm1Jni/Plcg2tm1Jni
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008782 increased B cell apoptosis "increase in the timing or the number of B cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Plcg2tm1Jni/Plcg2tm1Jni
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Blnktm1Kplm/Blnktm1Kplm,Plcg2tm1.1Kuro/Plcg2tm1.1Kuro
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Blnktm1Kplm/Blnktm1Kplm,Plcg2tm1.1Kuro/Plcg2+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Pik3r1tm1Dfr/Pik3r1tm1Dfr,Plcg2tm1Jni/Plcg2tm1Jni
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0009347 increased cancellous bone thickness "thicker than normal bone with a lattice-like or spongy structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Plcg2tm1Jni/Plcg2tm1Jni
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009549 impaired platelet aggregation "decrease in the ability of one platelet to one or more other platelets via adhesion molecules" [GO:0070527]
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Allelic Composition: Plcg2tm1Jni/Plcg2tm1Jni
Genetic Background: involves: 129P2/OlaHsd

 MP:0009925 increased transitional stage T2 B cell number "greater number of a type of a transitional stage B cell that has the phenotype surface IgM-positive, surface IgD-postive, CD21-positive, CD23-positive, CD62L-negative, and is located in the splenic B follicles" [PMID:12810111]
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Allelic Composition: Plcg2tm1Jni/Plcg2tm1Jni
Genetic Background: involves: 129P2/OlaHsd

 MP:0010740 abnormal dendritic cell chemotaxis "anomaly in the movement of a dendritic cell in response to an external stimulus" [GO:0002407]
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Allelic Composition: Plcg2tm1Jni/Plcg2tm1Jni
Genetic Background: involves: 129P2/OlaHsd

 MP:0010766 abnormal NK cell physiology "any functional anomaly of a lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors, and also regulate immune responses via cytokine release and direct contact with other cells" [GOC:add, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:15771571]
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Allelic Composition: Plcg2tm1.1Kuro/Plcg2tm1.1Kuro
Genetic Background: Not Specified

 MP:0010878 increased trabecular bone volume "increase in the amount of space occupied by trabecular bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Plcg2tm1Jni/Plcg2tm1Jni
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Blnktm1Kplm/Blnktm1Kplm,Plcg2tm1.1Kuro/Plcg2tm1.1Kuro
Genetic Background: involves: 129P2/OlaHsd

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Pik3r1tm1Dfr/Pik3r1tm1Dfr,Plcg2tm1Jni/Plcg2tm1Jni
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0012080 chylous ascites "the extravasation of milky triglyceride-rich chyle into the peritoneal cavity; often a secondary symptom of neoplasms" [MGI:csmith]
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Allelic Composition: Bdnftm1Par/Bdnf+,Ntrk2tm1.1Tes/Ntrk2+
Genetic Background: B6.129S1-Bdnftm1Par Ntrk2tm1.1Tes

Allelic Composition: Plcg2al/Plcg2al
Genetic Background: involves: 129 * C57BL/6

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
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Allelic Composition: Plcg2tm1Jni/Plcg2tm1Jni,Tg(IghMyc)22Bri/0
Genetic Background: involves: 129P2/OlaHsd * C57BL * C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000034116 Vav1 / P27870 / vav 1 oncogene / P15498* / vav guanine nucleotide exchange factor 1*  / reaction / complex
 ENSMUSG00000059923 Grb2 / Q60631 / Growth factor receptor-bound protein 2 / P62993*  / complex / reaction
 ENSMUSG00000020395 Itk / Q03526 / Tyrosine-protein kinase ITK/TSK / Q08881* / IL2 inducible T cell kinase*  / complex
 ENSMUSG00000026117 Zap70 / P43404 / zeta-chain (TCR) associated protein kinase / P43403* / zeta chain of T cell receptor associated protein kinase 70*  / reaction
 ENSMUSG00000022781 Pak2 / Q8CIN4 / Serine/threonine-protein kinase PAK 2 PAK-2p27 PAK-2p34 / Q13177* / p21 (RAC1) activated kinase 2*  / reaction / complex
 ENSMUSG00000042626 Shc1 / P98083 / SHC-transforming protein 1 / P29353* / SHC adaptor protein 1*  / complex / reaction
 ENSMUSG00000031264 Btk / P35991 / Tyrosine-protein kinase BTK / Q06187* / Bruton tyrosine kinase*  / complex / reaction
 ENSMUSG00000030742 Lat / O54957 / Linker for activation of T-cells family member 1 / O43561* / linker for activation of T cells*  / complex / reaction
 ENSMUSG00000042351 Grap2 / O89100 / GRB2-related adaptor protein 2 / O75791*  / complex / reaction
 ENSMUSG00000030774 Pak1 / Mus musculus p21 protein (Cdc42/Rac)-activated kinase 1 (Pak1), transcript variant 3, mRNA. / Q13153* / p21 (RAC1) activated kinase 1*  / reaction / complex
 ENSMUSG00000024241 Sos1 / Q62245 / Son of sevenless homolog 1 / Q07889* / SOS Ras/Rac guanine nucleotide exchange factor 1*  / complex / reaction
 ENSMUSG00000009621 Vav2 / Q60992 / vav 2 oncogene / P52735* / vav guanine nucleotide exchange factor 2*  / reaction / complex
 ENSMUSG00000021457 Syk / P48025 / spleen tyrosine kinase / P43405* / spleen associated tyrosine kinase*  / reaction / complex
 ENSMUSG00000033721 Vav3 / Q9R0C8 / vav 3 oncogene / Q9UKW4* / vav guanine nucleotide exchange factor 3*  / reaction / complex
 ENSMUSG00000000409 Lck / P06240 / Proto-onco tyrosine-protein kinase LCK / P06239* / LCK proto-oncogene, Src family tyrosine kinase*  / reaction
 ENSMUSG00000002699 Lcp2 / Q60787 / Lymphocyte cytosolic protein 2 / Q13094*  / complex / reaction
 ENSMUSG00000001847 Rac1 / P63001 / RAS-related C3 botulinum substrate 1 / P63000* / Rac family small GTPase 1*  / complex / reaction
 ENSMUSG00000005763 Cd247 / P24161 / T-cell surface glycoprotein CD3 zeta chain / P20963* / CD247 molecule*  / reaction / complex
 ENSMUSG00000059089 Fcgr4 / A0A0B4J1G0 / Low affinity immunoglobulin gamma Fc region receptor IV / P08637* / FCGR3A* / FCGR3B* / O75015* / Fc fragment of IgG receptor IIIa* / Fc fragment of IgG receptor IIIb*  / reaction / complex
 ENSMUSG00000015947 Fcgr1 / P26151 / High affinity immunoglobulin gamma Fc receptor I / Q92637* / FCGR1A* / FCGR1B* / P12314* / Fc fragment of IgG receptor Ib* / Fc fragment of IgG receptor Ia*  / reaction / complex
 ENSMUSG00000002033 Cd3g / P11942 / T-cell surface glycoprotein CD3 gamma chain / P09693* / CD3g molecule*  / reaction / complex
 ENSMUSG00000079293 Clec7a / Q6QLQ4 / Mus musculus C-type lectin domain family 7, member a (Clec7a), transcript variant 1, coding, mRNA. / Q9BXN2* / C-type lectin domain containing 7A*  / reaction






 

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