ENSMUSG00000024998


Mus musculus

Features
Gene ID: ENSMUSG00000024998
  
Biological name :Plce1
  
Synonyms : 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 / Plce1 / Q8K4S1
  
Possible biological names infered from orthology : phospholipase C epsilon 1 / Q9P212
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: C3
Gene start: 38481109
Gene end: 38785030
  
Corresponding Affymetrix probe sets: 10462922 (MoGene1.0st)   1452398_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000130604
Ensembl peptide - ENSMUSP00000138098
Ensembl peptide - ENSMUSP00000138330
Ensembl peptide - ENSMUSP00000138360
NCBI entrez gene - 74055     See in Manteia.
MGI - MGI:1921305
RefSeq - XM_011247380
RefSeq - NM_019588
RefSeq - XM_006527394
RefSeq - XM_006527395
RefSeq - XM_011247378
RefSeq - XM_011247379
RefSeq Peptide - NP_062534
swissprot - Q8K4S1
swissprot - S4R168
swissprot - S4R1Q8
Ensembl - ENSMUSG00000024998
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 plce1ENSDARG00000087921Danio rerio
 ENSGALG00000039528Gallus gallus
 ENSGALG00000040799Gallus gallus
 PLCE1ENSG00000138193Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Plcg1 / Q62077 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 / P19174* / phospholipase C gamma 1*ENSMUSG0000001693313
Plcg2 / Q8CIH5 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 / P16885* / phospholipase C gamma 2*ENSMUSG0000003433012


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR000159  Ras-associating (RA) domain
 IPR000909  Phosphatidylinositol-specific phospholipase C, X domain
 IPR001192  Phosphoinositide phospholipase C family
 IPR001711  Phospholipase C, phosphatidylinositol-specific, Y domain
 IPR001895  Ras guanine-nucleotide exchange factors catalytic domain
 IPR011992  EF-hand domain pair
 IPR017946  PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily
 IPR023578  Ras guanine nucleotide exchange factor domain superfamily
 IPR028398  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1
 IPR029071  Ubiquitin-like domain superfamily
 IPR035892  C2 domain superfamily
 IPR036964  Ras guanine-nucleotide exchange factor catalytic domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000187 activation of MAPK activity IEA
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007264 small GTPase mediated signal transduction IEA
 biological_processGO:0008277 regulation of G-protein coupled receptor protein signaling pathway IEA
 biological_processGO:0016042 lipid catabolic process IEA
 biological_processGO:0032835 glomerulus development IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0045859 regulation of protein kinase activity IEA
 biological_processGO:0046578 regulation of Ras protein signal transduction IEA
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol ISS
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0004435 phosphatidylinositol phospholipase C activity IEA
 molecular_functionGO:0004629 phospholipase C activity IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008081 phosphoric diester hydrolase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Synthesis of IP3 and IP4 in the cytosol


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
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Allelic Composition: Dnase2atm1Osa/Dnase2atm1Osa,Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0002746 abnormal semilunar valve morphology "malformation of the valves that gate the flow of blood from the ventricles into the aorta and pulmonary trunk" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:82728]
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Allelic Composition: Dnase2atm1Osa/Dnase2atm1Osa,Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0002753 dilated left ventricle "an expansion in the volume of the lower left chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Dnase2atm1Osa/Dnase2atm1Osa,Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0002754 dilated right ventricle "an expansion in the volume of the lower right chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Dnase2atm1Osa/Dnase2atm1Osa,Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0004215 abnormal myocardial fiber physiology "anomaly in the function of the multinucleated muscle cells of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Plce1tm1Avsm/Plce1tm1Avsm
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0004231 abnormal calcium ion homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of calcium ions within the body or between a cell and its external environment" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tyrc-55H/Tyrc-55H
Genetic Background: involves: 101/H * C3H/HeH

 MP:0004485 increased response of heart to induced stress "increase in severity of the physiological response of the heart to induced stress such as cardiac hypertrophy due to mechanical pressure overload from aortic banding" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Plce1tm1Avsm/Plce1tm1Avsm
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0004486 decreased response of heart to induced stress "decrease in severity of the physiological response of the heart to induced stress such as cardiac hypertrophy due to mechanical pressure overload from aortic banding" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ostm1om/Ostm1om
Genetic Background: C3HeB/FeJ-Ostm1om

 MP:0004502 decreased incidence of chemically-induced tumors "lower than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Dnase2atm1Osa/Dnase2atm1Osa,Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

Allelic Composition: Plce1tm1Tkat/Plce1+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Dnase2atm1Osa/Dnase2atm1Osa,Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

Allelic Composition: Plce1tm1Avsm/Plce1tm1Avsm
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0006047 aortic valve insufficiency "the aortic valve does not close tightly enough to prevent leakage. " [smb:Susan M Bello, Mouse Genome Informatics Curator, RGD:Rat Genome Database submission]
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Allelic Composition: Dnase2atm1Osa/Dnase2atm1Osa,Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0006048 pulmonary valve insufficiency "the pulmonary valve does not close tightly enough to prevent leakage" [smb:Susan M Bello, Mouse Genome Informatics Curator, RGD:Rat Genome Database submission]
Show

Allelic Composition: Dnase2atm1Osa/Dnase2atm1Osa,Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0006117 aortic valve stenosis "abnormal narrowing of the aortic valve" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Dnase2atm1Osa/Dnase2atm1Osa,Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Dnase2atm1Osa/Dnase2atm1Osa,Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

Allelic Composition: Plce1tm1Tkat/Plce1+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0010484 bicuspid aortic valve "the presence of two cusps in the aortic valve instead of three" [http://emedicine.medscape.com]
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Allelic Composition: Dnase2atm1Osa/Dnase2atm1Osa,Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0010594 thick aortic valve "an increase in the ratio of the aortic valve wall thickness to the aortic wall thickness" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dnase2atm1Osa/Dnase2atm1Osa,Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0010601 thick pulmonary valve "an increase in the ratio of the pulmonary valve wall thickness to the pulmonary artery wall thickness" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dnase2atm1Osa/Dnase2atm1Osa,Ifnar1tm1Agt/Ifnar1tm1Agt
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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