ENSMUSG00000079293


Mus musculus

Features
Gene ID: ENSMUSG00000079293
  
Biological name :Clec7a
  
Synonyms : Clec7a / Mus musculus C-type lectin domain family 7, member a (Clec7a), transcript variant 1, coding, mRNA. / Q6QLQ4
  
Possible biological names infered from orthology : C-type lectin domain containing 7A / Q9BXN2
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: F3
Gene start: 129461591
Gene end: 129472779
  
Corresponding Affymetrix probe sets: 10548375 (MoGene1.0st)   1420699_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000107707
Ensembl peptide - ENSMUSP00000139167
Ensembl peptide - ENSMUSP00000141234
NCBI entrez gene - 56644     See in Manteia.
MGI - MGI:1861431
RefSeq - NM_001309637
RefSeq - NM_020008
RefSeq Peptide - NP_001296566
RefSeq Peptide - NP_064392
swissprot - Q6QLQ4
swissprot - V9GXI5
Ensembl - ENSMUSG00000079293
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CLEC7AENSG00000172243Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Clec12b / C-type lectin domain family 12 member B / Q2HXU8*ENSMUSG0000003015829
Olr1 / Q9EQ09 / Oxidized low-density lipoprotein receptor 1 Oxidized low-density lipoprotein receptor 1, soluble form / P78380* / oxidized low density lipoprotein receptor 1*ENSMUSG0000003016229
Clec9a / Q8BRU4 / C-type lectin domain family 9 member A / Q6UXN8* / C-type lectin domain containing 9A*ENSMUSG0000004608026
Clec1a / Q8BWY2 / C-type lectin domain family 1 member A / Q8NC01*ENSMUSG0000003308226
Clec1b / Q9JL99 / C-type lectin domain family 1 member B / Q9P126*ENSMUSG0000003015926
Clec12a / Q5QGZ9* / C-type lectin domain family 12 member A*ENSMUSG0000005306321


Protein motifs (from Interpro)
Interpro ID Name
 IPR001304  C-type lectin-like
 IPR016186  C-type lectin-like/link domain superfamily
 IPR016187  C-type lectin fold
 IPR033992  Natural killer cell receptor-like, C-type lectin-like domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002366 leukocyte activation involved in immune response IDA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0071226 cellular response to molecule of fungal origin IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030246 carbohydrate binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
CLEC7A (Dectin-1) signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001663 abnormal digestive system physiology "altered function of the organ system that converts ingested food to nutrients and energy" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lmx1adr-10J/Lmx1adr-10J
Genetic Background: 129P3/J-Lmx1adr-10J/J

 MP:0001798 impaired macrophage phagocytosis "reduced ability of these phagocytic cells to internalize particulate matter" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Clec7atm1.1Bpip/Clec7atm1.1Bpip,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001845 abnormal inflammatory response "aberrant reaction of the microcirculation characterized by movement of fluid and leukocytes from the blood into extravascular tissues" [Pathology:ISBN 0-397-51047-0]
Show

Allelic Composition: Lmx1adr-10J/Lmx1adr-10J
Genetic Background: 129P3/J-Lmx1adr-10J/J

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Fhod3tm1Hsum/Fhod3+,Tg(Myh6-Fhod3*I1127A)#Hsum/0
Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj

 MP:0002376 abnormal dendritic cell physiology "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]
Show

Allelic Composition: Clec7atm1Yiw/Clec7atm1Yiw
Genetic Background: C.129P2-Clec7atm1Yiw

Allelic Composition: Clec7atm1Yiw/Clec7atm1Yiw,Myd88tm1Aki/Myd88tm1Aki
Genetic Background: involves: 129P2/OlaHsd * BALB/cA * C57BL/6J

Allelic Composition: Clec7atm1Yiw/Clec7atm1Yiw
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lmx1adr-10J/Lmx1adr-10J
Genetic Background: 129P3/J-Lmx1adr-10J/J

Allelic Composition: Clec7atm1Yiw/Clec7atm1Yiw
Genetic Background: C.129P2-Clec7atm1Yiw

Allelic Composition: Clec7atm1.1Bpip/Clec7atm1.1Bpip,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002463 abnormal neutrophil physiology "abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lmx1adr-10J/Lmx1adr-10J
Genetic Background: 129P3/J-Lmx1adr-10J/J

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lmx1adr-10J/Lmx1adr-10J
Genetic Background: 129P3/J-Lmx1adr-10J/J

Allelic Composition: Clec7atm1Yiw/Clec7atm1Yiw
Genetic Background: C.129P2-Clec7atm1Yiw

Allelic Composition: Clec7atm1Yiw/Clec7atm1Yiw,Myd88tm1Aki/Myd88tm1Aki
Genetic Background: involves: 129P2/OlaHsd * BALB/cA * C57BL/6J

 MP:0003883 enlarged stomach "increased size of the stomach" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Lmx1adr-10J/Lmx1adr-10J
Genetic Background: 129P3/J-Lmx1adr-10J/J

 MP:0004880 lung cysts 
Show

Allelic Composition: Clec7atm1Yiw/Clec7atm1Yiw
Genetic Background: C.129P2-Clec7atm1Yiw

 MP:0005399 increased susceptibility to fungal infection "greater likelihood that an organism will develop ill effects from infection by a yeast or mold, or from components of, or toxins produced by, these organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Lmx1adr-10J/Lmx1adr-10J
Genetic Background: 129P3/J-Lmx1adr-10J/J

Allelic Composition: Clec7atm1Yiw/Clec7atm1Yiw
Genetic Background: C.129P2-Clec7atm1Yiw

Allelic Composition: Clec7atm1Gdb/Clec7atm1Gdb
Genetic Background: B6.129S6-Clec7atm1Gdb

Allelic Composition: Clec7atm1.1Bpip/Clec7atm1.1Bpip,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008561 decreased tumor necrosis factor secretion "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Clec7atm1.1Bpip/Clec7atm1.1Bpip,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008588 abnormal circulating interleukin level "anomaly in the amount in the blood of soluble factors which stimulate growth-related activities of leukocytes as well as other cell types; they enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]
Show

Allelic Composition: Clec7atm1Gdb/Clec7atm1Gdb
Genetic Background: B6.129S6-Clec7atm1Gdb

 MP:0008615 decreased circulating interleukin-17 level "reduction in the amount in the blood of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517]
Show

Allelic Composition: Clec7atm1Gdb/Clec7atm1Gdb
Genetic Background: B6.129S6-Clec7atm1Gdb

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lmx1adr-10J/Lmx1adr-10J
Genetic Background: 129P3/J-Lmx1adr-10J/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000027646 Src / P05480 / Neuronal proto-onco tyrosine-protein kinase Src / P12931* / SRC proto-oncogene, non-receptor tyrosine kinase*  / reaction
 ENSMUSG00000034330 Plcg2 / Q8CIH5 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 / P16885* / phospholipase C gamma 2*  / reaction
 ENSMUSG00000021457 Syk / P48025 / spleen tyrosine kinase / P43405* / spleen associated tyrosine kinase*  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr