ENSMUSG00000030159


Mus musculus

Features
Gene ID: ENSMUSG00000030159
  
Biological name :Clec1b
  
Synonyms : Clec1b / C-type lectin domain family 1 member B / Q9JL99
  
Possible biological names infered from orthology : Q9P126
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: F3
Gene start: 129397297
Gene end: 129409335
  
Corresponding Affymetrix probe sets: 10542172 (MoGene1.0st)   1421182_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000032262
Ensembl peptide - ENSMUSP00000107710
Ensembl peptide - ENSMUSP00000107712
NCBI entrez gene - 56760     See in Manteia.
MGI - MGI:1913287
RefSeq - NM_001204239
RefSeq - NM_001204253
RefSeq - NM_019985
RefSeq Peptide - NP_001191168
RefSeq Peptide - NP_001191182
RefSeq Peptide - NP_064369
swissprot - Q9JL99
swissprot - A0T1G3
Ensembl - ENSMUSG00000030159
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CLEC1BENSG00000165682Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Clec1a / Q8BWY2 / C-type lectin domain family 1 member A / Q8NC01*ENSMUSG0000003308234
Clec12b / C-type lectin domain family 12 member B / Q2HXU8*ENSMUSG0000003015832
Clec9a / Q8BRU4 / C-type lectin domain family 9 member A / Q6UXN8* / C-type lectin domain containing 9A*ENSMUSG0000004608025
Clec12a / Q5QGZ9* / C-type lectin domain family 12 member A*ENSMUSG0000005306324
Olr1 / Q9EQ09 / Oxidized low-density lipoprotein receptor 1 Oxidized low-density lipoprotein receptor 1, soluble form / P78380* / oxidized low density lipoprotein receptor 1*ENSMUSG0000003016222
Clec7a / Q6QLQ4 / Mus musculus C-type lectin domain family 7, member a (Clec7a), transcript variant 1, coding, mRNA. / Q9BXN2* / C-type lectin domain containing 7A*ENSMUSG0000007929322


Protein motifs (from Interpro)
Interpro ID Name
 IPR001304  C-type lectin-like
 IPR016186  C-type lectin-like/link domain superfamily
 IPR016187  C-type lectin fold
 IPR033992  Natural killer cell receptor-like, C-type lectin-like domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007166 cell surface receptor signaling pathway TAS
 biological_processGO:0023014 signal transduction by protein phosphorylation ISS
 biological_processGO:0030220 platelet formation IGI
 cellular_componentGO:0005887 integral component of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity ISS
 molecular_functionGO:0030246 carbohydrate binding IEA


Pathways (from Reactome)
Pathway description
GPVI-mediated activation cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Il4tm1Kopf/Il4tm1Kopf,Lyntm1Ard/Lyntm1Ard
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0000496 abnormal small intestine morphology "structural or developmental anomalies of the intestinum tenue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Clec1btm1Ksi/Clec1btm1Ksi,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: C57BL/6

 MP:0001175 abnormal lung morphology "malformed organ of respiration" [J:35802]
Show

Allelic Composition: Clec1btm1.2Arte/Clec1btm1.2Arte
Genetic Background: Not Specified

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Il4tm1Kopf/Il4tm1Kopf,Lyntm1Ard/Lyntm1Ard
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Slc1a2tm1Kta/Slc1a2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Clec1btm1.1Arte/Clec1btm1.1Arte,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: C57BL/6

 MP:0001634 internal hemorrhage "blood loss in the interior of the body due to vessel rupture or dysmorphology " [J:23170]
Show

Allelic Composition: Il4tm1Kopf/Il4tm1Kopf,Lyntm1Ard/Lyntm1Ard
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
Show

Allelic Composition: Clec1btm1.2Arte/Clec1btm1.2Arte
Genetic Background: Not Specified

Allelic Composition: Clec1btm1.1Arte/Clec1btm1.1Arte,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: C57BL/6

 MP:0001786 skin edema "accumulation of an excessive amount of fluid in the skin" [J:65039]
Show

Allelic Composition: Slc1a2tm1Kta/Slc1a2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001879 abnormal lymphatic vessel morphology "malformation of the network of vessels which carries lymph around the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Slc1a2tm1Kta/Slc1a2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Clec1btm1Mlkn/Clec1btm1Mlkn
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Clec1btm1.2Arte/Clec1btm1.2Arte
Genetic Background: Not Specified

Allelic Composition: Clec1btm1.1Arte/Clec1btm1.1Arte,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: C57BL/6

Allelic Composition: Clec1btm1Ksi/Clec1btm1Ksi,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: C57BL/6

Allelic Composition: Gp6tm1Beni/Gp6tm1Beni,Clec1btm1.1Arte/Clec1btm1.1Arte,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: 129 * C57BL/6

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Slc1a2tm1Kta/Slc1a2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Clec1btm2Mlkn/Clec1btm2Mlkn,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0001915 intracranial hemorrhage "bleeding within the skull, including hemorrhage into the brain and within the cranial epidural, subdural, and subarachnoid spaces" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Clec1btm1.2Arte/Clec1btm1.2Arte
Genetic Background: Not Specified

Allelic Composition: Clec1btm1.1Arte/Clec1btm1.1Arte,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: C57BL/6

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gp6tm1Beni/Gp6tm1Beni,Clec1btm1.1Arte/Clec1btm1.1Arte,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: 129 * C57BL/6

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
Show

Allelic Composition: Clec1btm1.2Arte/Clec1btm1.2Arte
Genetic Background: Not Specified

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rras2tm1Itl/Rras2+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Clec1btm1.2Arte/Clec1btm1.2Arte
Genetic Background: Not Specified

 MP:0002551 abnormal blood coagulation "altered ability or inability of the blood to clot" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Clec1btm1.1Arte/Clec1btm1.1Arte,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: C57BL/6

 MP:0002843 decreased blood pressure "decreased tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Il4tm1Kopf/Il4tm1Kopf,Lyntm1Ard/Lyntm1Ard
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Il4tm1Kopf/Il4tm1Kopf,Lyntm1Ard/Lyntm1Ard
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
Show

Allelic Composition: Il4tm1Kopf/Il4tm1Kopf,Lyntm1Ard/Lyntm1Ard
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0003288 intestinal edema "an accumulation of an excessive amount of serous fluid in the intestine or intestinal cells " [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Clec1btm1Mlkn/Clec1btm1Mlkn
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Clec1btm1Ksi/Clec1btm1Ksi,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: C57BL/6

 MP:0004950 abnormal brain vasculature "any structural anomaly of the blood vessel network of the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il4tm1Kopf/Il4tm1Kopf,Lyntm1Ard/Lyntm1Ard
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

Allelic Composition: Clec1btm1.2Arte/Clec1btm1.2Arte
Genetic Background: Not Specified

 MP:0005324 ascites "accumulation or retention of fluid within the peritoneal cavity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Clec1btm1.1Arte/Clec1btm1.1Arte,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: C57BL/6

 MP:0005464 abnormal platelet physiology "atypical response of the non-nucleated cells found in the blood and involved in blood coagulation" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Rras2tm1Itl/Rras2+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Clec1btm1.1Arte/Clec1btm1.1Arte,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: C57BL/6

 MP:0005606 increased bleeding time "greater than the normal duration of blood flow after skin puncture; indicative of platelet and capillary function" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Gp6tm1Beni/Gp6tm1Beni,Clec1btm1.1Arte/Clec1btm1.1Arte,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: 129 * C57BL/6

 MP:0006054 spinal hemorrhage "bleeding into the spine" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Clec1btm1.2Arte/Clec1btm1.2Arte
Genetic Background: Not Specified

 MP:0006298 abnormal platelet activation "anomaly in the series of progressive, overlapping events triggered by exposure of platelets to signals from subendothelial tissue, including shape change, adhesiveness, aggregation, and release reactions; when carried through to completion, these events lead to the formation of a stable hemostatic plug" [GO:0030168, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc1a2tm1Kta/Slc1a2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Clec1btm1Mlkn/Clec1btm1Mlkn
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008247 abnormal mononuclear leukocyte morphology "any structural anomaly of a leukocyte with a single non-segmented nucleus in the mature form" [CL:0000842]
Show

Allelic Composition: Il4tm1Kopf/Il4tm1Kopf,Lyntm1Ard/Lyntm1Ard
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0009549 impaired platelet aggregation "decrease in the ability of one platelet to one or more other platelets via adhesion molecules" [GO:0070527]
Show

Allelic Composition: Slc1a2tm1Kta/Slc1a2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Clec1btm1.2Arte/Clec1btm1.2Arte
Genetic Background: Not Specified

 MP:0010022 brain vascular congestion "obstruction of the normal flux of blood within the blood vessel network of the brain" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il4tm1Kopf/Il4tm1Kopf,Lyntm1Ard/Lyntm1Ard
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0010197 abnormal lymphatic vessel endothelial cell morphology "any structural anomaly of the cells that line the lymphatic vessels" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Clec1btm1.1Arte/Clec1btm1.1Arte,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: C57BL/6

 MP:0010198 decreased lymphatic vessel endothelial cell number "reduced number of the cells that line the lymphatic vessels" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Clec1btm1.2Arte/Clec1btm1.2Arte
Genetic Background: Not Specified

 MP:0010368 abnormal lymphatic system physiology "any functional anomaly of the interconnected system of spaces, organs and vessels between body tissues and organs through which fluid, fats, proteins, and lymphocytes are transported to the bloodstream as lymph, and microorganisms and other debris are removed from tissues" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc1a2tm1Kta/Slc1a2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010819 primary atelectasis "nonexpansion of the lungs after birth, seen in stillborn organisms and in live born animals that do not establish respiration" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Clec1btm1.2Arte/Clec1btm1.2Arte
Genetic Background: Not Specified

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Slc1a2tm1Kta/Slc1a2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Rras2tm1Itl/Rras2+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Clec1btm1.2Arte/Clec1btm1.2Arte
Genetic Background: Not Specified

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Il4tm1Kopf/Il4tm1Kopf,Lyntm1Ard/Lyntm1Ard
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

Allelic Composition: Clec1btm1.2Arte/Clec1btm1.2Arte
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Clec1btm1.2Arte/Clec1btm1.2Arte
Genetic Background: Not Specified

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Slc1a2tm1Kta/Slc1a2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Clec1btm1.1Ksi/Clec1btm1.1Ksi
Genetic Background: involves: C57BL/6

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Il4tm1Kopf/Il4tm1Kopf,Lyntm1Ard/Lyntm1Ard
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0011514 skin hemorrhage "bleeding into the skin" [MGI:anna]
Show

Allelic Composition: Clec1btm1.2Arte/Clec1btm1.2Arte
Genetic Background: Not Specified

 MP:0011898 abnormal platelet cell number "anomaly in the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation" [MGI:csmith]
Show

Allelic Composition: Gp6tm1Beni/Gp6tm1Beni,Clec1btm1.1Arte/Clec1btm1.1Arte,Tg(Pf4-icre)Q3Rsko/0
Genetic Background: involves: 129 * C57BL/6

 MP:0012080 chylous ascites "the extravasation of milky triglyceride-rich chyle into the peritoneal cavity; often a secondary symptom of neoplasms" [MGI:csmith]
Show

Allelic Composition: Clec1btm1.2Arte/Clec1btm1.2Arte
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000030159 Clec1b / Q9JL99 / C-type lectin domain family 1 member B / Q9P126*  / complex
 ENSMUSG00000021457 Syk / P48025 / spleen tyrosine kinase / P43405* / spleen associated tyrosine kinase*  / complex / reaction
 ENSMUSG00000028583 Pdpn / Q62011 / Podoplanin / Q86YL7*  / reaction / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr