ENSMUSG00000053063


Mus musculus

Features
Gene ID: ENSMUSG00000053063
  
Biological name :Clec12a
  
Synonyms : Clec12a
  
Possible biological names infered from orthology : C-type lectin domain family 12 member A / Q5QGZ9
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: F3
Gene start: 129342691
Gene end: 129365303
  
Corresponding Affymetrix probe sets: 10542164 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000063627
Ensembl peptide - ENSMUSP00000118315
NCBI entrez gene - 232413     See in Manteia.
MGI - MGI:3040968
RefSeq - NM_177686
RefSeq - XM_011241323
RefSeq Peptide - NP_808354
swissprot - D3YXD8
swissprot - A0A0R4J0T2
Ensembl - ENSMUSG00000053063
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q5QGZ9ENSG00000172322Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Clec12b / C-type lectin domain family 12 member B / Q2HXU8*ENSMUSG0000003015826
Clec1a / Q8BWY2 / C-type lectin domain family 1 member A / Q8NC01*ENSMUSG0000003308222
Clec1b / Q9JL99 / C-type lectin domain family 1 member B / Q9P126*ENSMUSG0000003015920
Olr1 / Q9EQ09 / Oxidized low-density lipoprotein receptor 1 Oxidized low-density lipoprotein receptor 1, soluble form / P78380* / oxidized low density lipoprotein receptor 1*ENSMUSG0000003016219
Clec9a / Q8BRU4 / C-type lectin domain family 9 member A / Q6UXN8* / C-type lectin domain containing 9A*ENSMUSG0000004608017
Clec7a / Q6QLQ4 / Mus musculus C-type lectin domain family 7, member a (Clec7a), transcript variant 1, coding, mRNA. / Q9BXN2* / C-type lectin domain containing 7A*ENSMUSG0000007929316


Protein motifs (from Interpro)
Interpro ID Name
 IPR001304  C-type lectin-like
 IPR016186  C-type lectin-like/link domain superfamily
 IPR016187  C-type lectin fold
 IPR033992  Natural killer cell receptor-like, C-type lectin-like domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0030246 carbohydrate binding IEA


Pathways (from Reactome)
Pathway description
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fgfr1tm1Jpa/Fgfr1tm1Jpa,Fgfr2tm1Dor/Fgfr2tm1Dor,Twist2tm1.1(cre)Dor/Twist2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Braftm1Cpri/Braftm1Cpri,Gnastm3Lsw/Gnastm3Lsw,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * FVB/NCr

 MP:0002463 abnormal neutrophil physiology "abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fgfr1tm1Jpa/Fgfr1tm1Jpa,Fgfr2tm1Dor/Fgfr2tm1Dor,Twist2tm1.1(cre)Dor/Twist2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003674 oxidative stress "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Fgfr1tm1Jpa/Fgfr1tm1Jpa,Fgfr2tm1Dor/Fgfr2tm1Dor,Twist2tm1.1(cre)Dor/Twist2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008260 abnormal autophagy "abnormal catabolic process involving the degradation of a cell s own components through the lysosomal machinery" [MGI:honda "Hiraoki Onda, Mouse Genome Informatics Curator"]
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Allelic Composition: Braftm1Cpri/Braftm1Cpri,Gnastm3Lsw/Gnastm3Lsw,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * FVB/NCr

 MP:0008560 increased tumor necrosis factor secretion "increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Fgfr1tm1Jpa/Fgfr1tm1Jpa,Fgfr2tm1Dor/Fgfr2tm1Dor,Twist2tm1.1(cre)Dor/Twist2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008722 abnormal chemokine secretion "anomaly in the production or cellular release of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200]
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Allelic Composition: Fgfr1tm1Jpa/Fgfr1tm1Jpa,Fgfr2tm1Dor/Fgfr2tm1Dor,Twist2tm1.1(cre)Dor/Twist2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009278 abnormal bone marrow cell physiology "any functional anomaly of any of the cells found in the blood" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Fgfr1tm1Jpa/Fgfr1tm1Jpa,Fgfr2tm1Dor/Fgfr2tm1Dor,Twist2tm1.1(cre)Dor/Twist2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009788 increased susceptibility to bacterial infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Braftm1Cpri/Braftm1Cpri,Gnastm3Lsw/Gnastm3Lsw,Tg(TPO-cre)1Shk/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * FVB/NCr

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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