ENSMUSG00000030162


Mus musculus

Features
Gene ID: ENSMUSG00000030162
  
Biological name :Olr1
  
Synonyms : Olr1 / Oxidized low-density lipoprotein receptor 1 Oxidized low-density lipoprotein receptor 1, soluble form / Q9EQ09
  
Possible biological names infered from orthology : oxidized low density lipoprotein receptor 1 / P78380
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: F3
Gene start: 129485244
Gene end: 129507165
  
Corresponding Affymetrix probe sets: 10548385 (MoGene1.0st)   1419534_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000138588
Ensembl peptide - ENSMUSP00000144833
Ensembl peptide - ENSMUSP00000032265
Ensembl peptide - ENSMUSP00000124660
Ensembl peptide - ENSMUSP00000138228
NCBI entrez gene - 108078     See in Manteia.
MGI - MGI:1261434
RefSeq - XM_017321300
RefSeq - NM_001301094
RefSeq - NM_001301096
RefSeq - NM_138648
RefSeq - XM_017321299
RefSeq Peptide - NP_001288025
RefSeq Peptide - NP_001288023
RefSeq Peptide - NP_619589
swissprot - G4WK10
swissprot - A0A0N4SUV1
swissprot - G4WK09
swissprot - E0CXW6
swissprot - Q9EQ09
Ensembl - ENSMUSG00000030162
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 OLR1ENSG00000173391Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Clec12b / C-type lectin domain family 12 member B / Q2HXU8*ENSMUSG0000003015816
Clec1a / Q8BWY2 / C-type lectin domain family 1 member A / Q8NC01*ENSMUSG0000003308216
Clec7a / Q6QLQ4 / Mus musculus C-type lectin domain family 7, member a (Clec7a), transcript variant 1, coding, mRNA. / Q9BXN2* / C-type lectin domain containing 7A*ENSMUSG0000007929316
Clec1b / Q9JL99 / C-type lectin domain family 1 member B / Q9P126*ENSMUSG0000003015914
Clec12a / Q5QGZ9* / C-type lectin domain family 12 member A*ENSMUSG0000005306314
Clec9a / Q8BRU4 / C-type lectin domain family 9 member A / Q6UXN8* / C-type lectin domain containing 9A*ENSMUSG0000004608012


Protein motifs (from Interpro)
Interpro ID Name
 IPR001304  C-type lectin-like
 IPR016186  C-type lectin-like/link domain superfamily
 IPR016187  C-type lectin fold
 IPR033992  Natural killer cell receptor-like, C-type lectin-like domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006898 receptor-mediated endocytosis IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0007155 cell adhesion IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0019897 extrinsic component of plasma membrane TAS
 cellular_componentGO:0043231 intracellular membrane-bounded organelle ISO
 cellular_componentGO:0043235 receptor complex ISO
 cellular_componentGO:0045121 membrane raft IEA
 molecular_functionGO:0005041 low-density lipoprotein particle receptor activity IDA
 molecular_functionGO:0030246 carbohydrate binding IEA
 molecular_functionGO:0042802 identical protein binding ISO


Pathways (from Reactome)
Pathway description
Cell surface interactions at the vascular wall
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000182 increased circulating LDL cholesterol level "greater than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Olr1tm1Meht/Olr1tm1Meht
Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ * C57BL/6

 MP:0000186 decreased circulating HDL cholesterol level "lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Olr1tm1Meht/Olr1tm1Meht
Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dgat2tm1Lex/Dgat2tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0003038 decreased infarction size "decreased size of necrotic area from normal of the myocardium resulting from a sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Pou5f1tm1Jae/Pou5f1tm1Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004037 increased muscle relaxation "greater than the normal ability of the muscle to lengthen following contractions or increase in the ability of the muscle to lengthen following contractions" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Pou5f1tm1Jae/Pou5f1tm1Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004484 altered response of heart to induced stress "change in the physiological response of the heart to induced stress such as cardiac hypertrophy due to mechanical pressure overload from aortic banding" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pou5f1tm1Jae/Pou5f1tm1Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005145 increased circulating VLDL cholesterol level "greater than average concentration in the blood of very low density lipoprotein, which normally transports triglycerides from the intestine and liver to muscle and adipose tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Olr1tm1Meht/Olr1tm1Meht
Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ * C57BL/6

 MP:0005341 decreased susceptibility to atherosclerosis "less likely than the norm to develop thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pou5f1tm1Jae/Pou5f1tm1Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Olr1tm1Meht/Olr1tm1Meht
Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ * C57BL/6

 MP:0008593 increased circulating interleukin-10 level "increase in the amount in the blood of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
Show

Allelic Composition: Pou5f1tm1Jae/Pou5f1tm1Jae
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Olr1tm1Meht/Olr1tm1Meht
Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000030162 Olr1 / Q9EQ09 / Oxidized low-density lipoprotein receptor 1 Oxidized low-density lipoprotein receptor 1, soluble form / P78380* / oxidized low density lipoprotein receptor 1*  / complex / reaction






 

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