ENSMUSG00000028583


Mus musculus

Features
Gene ID: ENSMUSG00000028583
  
Biological name :Pdpn
  
Synonyms : Pdpn / Podoplanin / Q62011
  
Possible biological names infered from orthology : Q86YL7
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: E1
Gene start: 143267431
Gene end: 143299564
  
Corresponding Affymetrix probe sets: 10518147 (MoGene1.0st)   1419309_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000030317
Ensembl peptide - ENSMUSP00000113776
NCBI entrez gene - 14726     See in Manteia.
MGI - MGI:103098
RefSeq - NM_001290822
RefSeq - NM_010329
RefSeq Peptide - NP_001277751
RefSeq Peptide - NP_034459
swissprot - Q62011
swissprot - A8Y5F6
Ensembl - ENSMUSG00000028583
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000030096Gallus gallus
 PDPNENSG00000162493Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR008783  Podoplanin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000902 cell morphogenesis IDA
 biological_processGO:0001946 lymphangiogenesis IMP
 biological_processGO:0006693 prostaglandin metabolic process IMP
 biological_processGO:0007155 cell adhesion ISO
 biological_processGO:0007165 signal transduction IMP
 biological_processGO:0007266 Rho protein signal transduction ISS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0008283 cell proliferation IMP
 biological_processGO:0008285 negative regulation of cell proliferation IMP
 biological_processGO:0008360 regulation of cell shape IEA
 biological_processGO:0010718 positive regulation of epithelial to mesenchymal transition ISO
 biological_processGO:0030155 regulation of cell adhesion IMP
 biological_processGO:0030324 lung development IMP
 biological_processGO:0030335 positive regulation of cell migration ISS
 biological_processGO:0035239 tube morphogenesis ISO
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0044319 wound healing, spreading of cells ISS
 biological_processGO:0048286 lung alveolus development IMP
 biological_processGO:0048535 lymph node development IMP
 biological_processGO:0051272 positive regulation of cellular component movement IDA
 biological_processGO:0060838 lymphatic endothelial cell fate commitment IMP
 biological_processGO:0061032 visceral serous pericardium development TAS
 biological_processGO:0070252 actin-mediated cell contraction IDA
 biological_processGO:0090091 positive regulation of extracellular matrix disassembly ISO
 biological_processGO:0098609 cell-cell adhesion IMP
 biological_processGO:1900024 regulation of substrate adhesion-dependent cell spreading IMP
 biological_processGO:1901731 positive regulation of platelet aggregation IMP
 biological_processGO:1904328 regulation of myofibroblast contraction IMP
 biological_processGO:1905863 invadopodium organization ISO
 biological_processGO:2000045 regulation of G1/S transition of mitotic cell cycle IMP
 biological_processGO:2000392 regulation of lamellipodium morphogenesis ISO
 cellular_componentGO:0001726 ruffle IDA
 cellular_componentGO:0005829 cytosol ISS
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane ISS
 cellular_componentGO:0016324 apical plasma membrane ISS
 cellular_componentGO:0030027 lamellipodium IDA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030175 filopodium IDA
 cellular_componentGO:0031258 lamellipodium membrane ISO
 cellular_componentGO:0031410 cytoplasmic vesicle ISO
 cellular_componentGO:0031527 filopodium membrane ISS
 cellular_componentGO:0031528 microvillus membrane ISO
 cellular_componentGO:0032587 ruffle membrane ISS
 cellular_componentGO:0042995 cell projection ISO
 cellular_componentGO:0045121 membrane raft ISO
 cellular_componentGO:0061851 leading edge of lamellipodium ISO
 cellular_componentGO:0071437 invadopodium ISO
 cellular_componentGO:0097197 tetraspanin-enriched microdomain ISO
 molecular_functionGO:0005102 signaling receptor binding ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019956 chemokine binding ISO
 molecular_functionGO:0051087 chaperone binding ISO


Pathways (from Reactome)
Pathway description
GPVI-mediated activation cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
Show

Allelic Composition: Col1a1m1Btlr/Col1a1m1Btlr
Genetic Background: C57BL/6J-Col1a1m1Btlr

 MP:0000281 abnormal ventricular septum morphology "abnormality in the wall between the ventricles of the heart, usually incomplete closure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Col1a1m1Btlr/Col1a1m1Btlr
Genetic Background: C57BL/6J-Col1a1m1Btlr

 MP:0000301 reduced size of endocardial cushions "smaller than normal mounds of embryonic connective tissue that bulge into the embryonic atrioventricular canal" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:29973]
Show

Allelic Composition: Col1a1m1Btlr/Col1a1m1Btlr
Genetic Background: C57BL/6J-Col1a1m1Btlr

 MP:0000726 absent lymphocyte "lack of specific white blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pdpntm2.1Mlkn/Pdpntm2.1Mlkn,Rag1tm1Mom/Rag1tm1Mom,Tg(Pdgfrb-cre)9Rha/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001175 abnormal lung morphology "malformed organ of respiration" [J:35802]
Show

Allelic Composition: Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129S2/SvPas * BALB/c * CF-1

 MP:0001177 atelectasis "collapse of the lung or any portion of the lung, or decreased or absent air in the lung, resulting in loss of lung volume " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129S2/SvPas * BALB/c * CF-1

 MP:0001179 thicker alveolar septa 
Show

Allelic Composition: Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129S2/SvPas * BALB/c * CF-1

 MP:0001284 absent vibrissae "missing whiskers" [J:18378]
Show

Allelic Composition: Pdgfrbtm1b(EUCOMM)Hmgu/Pdgfrb+
Genetic Background: C57BL/6N-Pdgfrbtm1b(EUCOMM)Hmgu/H

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
Show

Allelic Composition: Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129S2/SvPas * BALB/c * CF-1

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ccr2tm1.1(CCR2)Rodb/Ccr2tm1.1(CCR2)Rodb
Genetic Background: involves: C57BL/6

 MP:0001879 abnormal lymphatic vessel morphology "malformation of the network of vessels which carries lymph around the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129S2/SvPas * BALB/c * CF-1

Allelic Composition: Pdpntm1Mcws/Pdpn+
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Pdpntm1(cre)Mlkn/Pdpntm1(cre)Mlkn
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ccr2tm1.1(CCR2)Rodb/Ccr2tm1.1(CCR2)Rodb
Genetic Background: involves: C57BL/6

Allelic Composition: Pdpntm2.1Mlkn/Pdpntm2.1Mlkn,Tg(Pdgfrb-cre)9Rha/0
Genetic Background: involves: C57BL/6

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
Show

Allelic Composition: Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129S2/SvPas * BALB/c * CF-1

Allelic Composition: Pdpntm1Bwd/Pdpntm1Bwd
Genetic Background: either: (involves: Black Swiss) or (involves: C57BL/6)

 MP:0002189 abnormal myocardial trabeculae morphology "malformation of the supporting bundles of muscular fibers lining the walls of the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Col1a1m1Btlr/Col1a1m1Btlr
Genetic Background: C57BL/6J-Col1a1m1Btlr

 MP:0002270 abnormal alveoli morphology "any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129S2/SvPas * BALB/c * CF-1

 MP:0002274 abnormal type I pneumocyte morphology "any structural anomaly of the epithelial cells lining the alveoli through which gas exchange occurs; these are thin cells with a large surface area" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0]
Show

Allelic Composition: Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129S2/SvPas * BALB/c * CF-1

 MP:0002339 abnormal lymph node morphology "anomalous structure, size, or celluarity of the oval or bean shaped bodies located along the lymphatic system" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ccr2tm1.1(CCR2)Rodb/Ccr2tm1.1(CCR2)Rodb
Genetic Background: involves: C57BL/6

 MP:0002652 thin myocardial wall "thinly developed cardiac muscle layers" [il:Ira Lu , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Col1a1m1Btlr/Col1a1m1Btlr
Genetic Background: C57BL/6J-Col1a1m1Btlr

 MP:0003057 abnormal epicardium morphology "anomalous structure of the visceral layer of the pericardium that surrounds and attaches to all the surfaces of the heart" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Col1a1m1Btlr/Col1a1m1Btlr
Genetic Background: C57BL/6J-Col1a1m1Btlr

 MP:0003070 increased vascular permeability "greater or faster ability of the blood vessels to permit the passage of substances such as fluid, heat, or gases" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ccr2tm1.1(CCR2)Rodb/Ccr2tm1.1(CCR2)Rodb
Genetic Background: involves: C57BL/6

 MP:0003288 intestinal edema "an accumulation of an excessive amount of serous fluid in the intestine or intestinal cells " [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Pdpntm1(cre)Mlkn/Pdpntm1(cre)Mlkn
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003390 lymphedema "abnormal swelling in the soft tissues of the limbs, or less often the trunk, caused by the buildup of lymph fluid" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129S2/SvPas * BALB/c * CF-1

 MP:0003659 abnormal lymph circulation "abnormalities in the flow of the lymph from the tissues into the veins of the circulatory system" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:95885]
Show

Allelic Composition: Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129S2/SvPas * BALB/c * CF-1

 MP:0004038 lymphangiectasis "dilation of the lymphatic vessels, the basic process that may result in the formation of a lymphangioma" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:71816]
Show

Allelic Composition: Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129S2/SvPas * BALB/c * CF-1

Allelic Composition: Pdpntm1Mcws/Pdpn+
Genetic Background: involves: 129S6/SvEvTac

 MP:0004056 abnormal myocardial compact layer morphology "malformation of the outer, dense layer of the myocardium " [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Col1a1m1Btlr/Col1a1m1Btlr
Genetic Background: C57BL/6J-Col1a1m1Btlr

 MP:0004111 abnormal coronary artery morphology "anomaly of any of the arteries that branch from the aorta to supply blood to the heart" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Col1a1m1Btlr/Col1a1m1Btlr
Genetic Background: C57BL/6J-Col1a1m1Btlr

 MP:0004197 abnormal fetal growth/weight/body size "limited or accelerated growth or development apparent during the fetal period (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129S2/SvPas * BALB/c * CF-1

 MP:0005202 lethargy "mild impairment of consciousness resulting in reduced alertness and awareness; ultimately due to generalized brain dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129S2/SvPas * BALB/c * CF-1

 MP:0005329 abnormal cardiac muscle morphology "anomalous structure of the involuntary muscle comprising the myocardium " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Col1a1m1Btlr/Col1a1m1Btlr
Genetic Background: C57BL/6J-Col1a1m1Btlr

 MP:0008464 absent peripheral lymph nodes "absence of the lymph nodes located outside the thoracic and abdominal cavities, such as the submandibular, prescapular, axillary, inguinal and popliteal lymph nodes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ccr2tm1.1(CCR2)Rodb/Ccr2tm1.1(CCR2)Rodb
Genetic Background: involves: C57BL/6

 MP:0008778 lymphangiogenesis "any anomaly in the formation of lymphatic vessels from pre-existing lymphatic vessels" [MESH:G07.574.500.325.377.500]
Show

Allelic Composition: Cyp26b1tm1Hh/Cyp26b1tm1Hh,Tg(Prox1-EGFP)KY221Gsat/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/NTac

 MP:0009432 increased fetal weight "increase in the weight of a fetus compared to controls (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pdpntm1Bwd/Pdpntm1Bwd
Genetic Background: either: (involves: Black Swiss) or (involves: C57BL/6)

 MP:0009931 abnormal skin appearance "skin that looks different from the usual state" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129S2/SvPas * BALB/c * CF-1

 MP:0010426 abnormal heart and great artery attachment "any anomaly in the in the position or pattern of the connection site of the heart to any of the great arteries, including the pulmonary artery and aorta" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Col1a1m1Btlr/Col1a1m1Btlr
Genetic Background: C57BL/6J-Col1a1m1Btlr

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129S2/SvPas * BALB/c * CF-1

Allelic Composition: Pdpntm1Bwd/Pdpntm1Bwd
Genetic Background: either: (involves: Black Swiss) or (involves: C57BL/6)

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Col1a1m1Btlr/Col1a1m1Btlr
Genetic Background: C57BL/6J-Col1a1m1Btlr

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Col1a1m1Btlr/Col1a1m1Btlr
Genetic Background: C57BL/6J-Col1a1m1Btlr

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Col1a1m1Btlr/Col1a1m1Btlr
Genetic Background: C57BL/6J-Col1a1m1Btlr

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Pdgfrbtm1b(EUCOMM)Hmgu/Pdgfrb+
Genetic Background: C57BL/6N-Pdgfrbtm1b(EUCOMM)Hmgu/H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000030159 Clec1b / Q9JL99 / C-type lectin domain family 1 member B / Q9P126*  / complex / reaction
 ENSMUSG00000021457 Syk / P48025 / spleen tyrosine kinase / P43405* / spleen associated tyrosine kinase*  / complex / reaction






 

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