ENSG00000162493


Homo sapiens

Features
Gene ID: ENSG00000162493
  
Biological name :PDPN
  
Synonyms : PDPN / podoplanin / Q86YL7
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: p36.21
Gene start: 13583465
Gene end: 13617957
  
Corresponding Affymetrix probe sets: 204879_at (Human Genome U133 Plus 2.0 Array)   208233_at (Human Genome U133 Plus 2.0 Array)   221898_at (Human Genome U133 Plus 2.0 Array)   226658_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000426302
Ensembl peptide - ENSP00000479591
Ensembl peptide - ENSP00000478125
Ensembl peptide - ENSP00000427537
Ensembl peptide - ENSP00000294489
Ensembl peptide - ENSP00000365225
Ensembl peptide - ENSP00000365229
Ensembl peptide - ENSP00000421742
Ensembl peptide - ENSP00000422977
Ensembl peptide - ENSP00000425304
Ensembl peptide - ENSP00000426063
Ensembl peptide - ENSP00000426210
NCBI entrez gene - 10630     See in Manteia.
OMIM - 608863
RefSeq - XM_006710295
RefSeq - NM_001006624
RefSeq - NM_001006625
RefSeq - NM_006474
RefSeq - NM_198389
RefSeq Peptide - NP_006465
RefSeq Peptide - NP_001006625
RefSeq Peptide - NP_001006626
RefSeq Peptide - NP_938203
swissprot - H0YA72
swissprot - D6RH07
swissprot - Q86YL7
swissprot - E7ETC6
swissprot - H0Y8Q3
Ensembl - ENSG00000162493
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000030096Gallus gallus
 PdpnENSMUSG00000028583Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR008783  Podoplanin
 IPR021157  Cytochrome c1, transmembrane anchor, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000902 cell morphogenesis ISS
 biological_processGO:0001946 lymphangiogenesis ISS
 biological_processGO:0007266 Rho protein signal transduction IMP
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0008285 negative regulation of cell proliferation ISS
 biological_processGO:0008360 regulation of cell shape IEA
 biological_processGO:0010718 positive regulation of epithelial to mesenchymal transition IMP
 biological_processGO:0030168 platelet activation TAS
 biological_processGO:0030324 lung development ISS
 biological_processGO:0030335 positive regulation of cell migration IMP
 biological_processGO:0043066 negative regulation of apoptotic process ISS
 biological_processGO:0044319 wound healing, spreading of cells IMP
 biological_processGO:0048535 lymph node development ISS
 biological_processGO:0051272 positive regulation of cellular component movement ISS
 biological_processGO:0060838 lymphatic endothelial cell fate commitment ISS
 biological_processGO:0070252 actin-mediated cell contraction ISS
 biological_processGO:0090091 positive regulation of extracellular matrix disassembly IDA
 biological_processGO:1900024 regulation of substrate adhesion-dependent cell spreading ISS
 biological_processGO:1901731 positive regulation of platelet aggregation IMP
 biological_processGO:1904328 regulation of myofibroblast contraction ISS
 biological_processGO:1905863 invadopodium organization IDA
 biological_processGO:2000392 regulation of lamellipodium morphogenesis IMP
 cellular_componentGO:0001726 ruffle ISS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0030027 lamellipodium ISS
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030175 filopodium ISS
 cellular_componentGO:0031258 lamellipodium membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IDA
 cellular_componentGO:0031527 filopodium membrane IEA
 cellular_componentGO:0031528 microvillus membrane IEA
 cellular_componentGO:0032587 ruffle membrane IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0045121 membrane raft IEA
 cellular_componentGO:0061851 leading edge of lamellipodium IDA
 cellular_componentGO:0071437 invadopodium IEA
 cellular_componentGO:0097197 tetraspanin-enriched microdomain IDA
 molecular_functionGO:0005102 signaling receptor binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019956 chemokine binding IPI
 molecular_functionGO:0051087 chaperone binding IPI


Pathways (from Reactome)
Pathway description
GPVI-mediated activation cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000165025 SYK / P43405 / spleen associated tyrosine kinase  / complex / reaction
 ENSG00000165682 CLEC1B / Q9P126 / C-type lectin domain family 1 member B  / reaction / complex






 

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