ENSGALG00000033507


Gallus gallus

Features
Gene ID: ENSGALG00000033507
  
Biological name :PLCG2
  
Synonyms : phospholipase C gamma 2 / PLCG2
  
Possible biological names infered from orthology : 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 / P16885 / Q8CIH5
  
Species: Gallus gallus
  
Chr. number: 11
Strand: 1
Band:
Gene start: 15896527
Gene end: 15947034
  
Corresponding Affymetrix probe sets: Gga.7148.1.S1_at (Chicken Array)   Gga.7148.2.A1_at (Chicken Array)   GgaAffx.22378.1.S1_at (Chicken Array)   GgaAffx.22378.1.S1_s_at (Chicken Array)   GgaAffx.3425.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000052324
Ensembl peptide - ENSGALP00000053598
NCBI entrez gene - 415805     See in Manteia.
RefSeq - XM_414166
RefSeq - XM_004944258
swissprot - A0A1D5PL83
swissprot - A0A1D5PHP4
Ensembl - ENSGALG00000033507
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 plcg2ENSDARG00000068763Danio rerio
 PLCG2ENSG00000197943Homo sapiens
 Plcg2ENSMUSG00000034330Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ENSGALG0000003608553
PLCG1 / phospholipase C gamma 1 / P19174* / Q62077* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 *ENSGALG0000000375051
PLCE1* / Q8K4S1* / Q9P212* / phospholipase C epsilon 1* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 *ENSGALG0000003952814
PLCE1* / Q8K4S1* / Q9P212* / phospholipase C epsilon 1* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 *ENSGALG000000407999


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR000909  Phosphatidylinositol-specific phospholipase C, X domain
 IPR000980  SH2 domain
 IPR001192  Phosphoinositide phospholipase C family
 IPR001452  SH3 domain
 IPR001711  Phospholipase C, phosphatidylinositol-specific, Y domain
 IPR001849  Pleckstrin homology domain
 IPR011992  EF-hand domain pair
 IPR011993  PH-like domain superfamily
 IPR016279  Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma
 IPR017946  PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily
 IPR028381  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002092 positive regulation of receptor internalization IEA
 biological_processGO:0002316 follicular B cell differentiation IEA
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006661 phosphatidylinositol biosynthetic process IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0009395 phospholipid catabolic process IEA
 biological_processGO:0010468 regulation of gene expression IEA
 biological_processGO:0016042 lipid catabolic process IEA
 biological_processGO:0030183 B cell differentiation IEA
 biological_processGO:0032237 activation of store-operated calcium channel activity IEA
 biological_processGO:0032481 positive regulation of type I interferon production IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0032959 inositol trisphosphate biosynthetic process IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0043069 negative regulation of programmed cell death IEA
 biological_processGO:0050852 T cell receptor signaling pathway IEA
 biological_processGO:0050853 B cell receptor signaling pathway IEA
 biological_processGO:0051209 release of sequestered calcium ion into cytosol IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 molecular_functionGO:0001784 phosphotyrosine residue binding IEA
 molecular_functionGO:0004435 phosphatidylinositol phospholipase C activity IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0008081 phosphoric diester hydrolase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
GPVI-mediated activation cascade
Toll Like Receptor 4 (TLR4) Cascade
Synthesis of IP3 and IP4 in the cytosol
Role of phospholipids in phagocytosis
DAP12 signaling
FCERI mediated MAPK activation
FCERI mediated Ca+2 mobilization
CLEC7A (Dectin-1) signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000000466 LCK / LCK proto-oncogene, Src family tyrosine kinase / P06239* / P06240* / Proto-onco tyrosine-protein kinase LCK *  / reaction
 ENSGALG00000001486 ZAP70 / Gallus gallus zeta-chain (TCR) associated protein kinase 70kDa (ZAP70), mRNA. / P43404* / P43403* / zeta-chain (TCR) associated protein kinase* / zeta chain of T cell receptor assoc...  / reaction
 ENSGALG00000002113 LCP2 / lymphocyte cytosolic protein 2 / Q13094* / Q60787*  / complex / reaction
 ENSGALG00000003857 ITK / IL2 inducible T cell kinase / Q03526* / Q08881* / Tyrosine-protein kinase ITK/TSK *  / complex
 ENSGALG00000007130 RAC1 / Rac family small GTPase 1 / P63000* / P63001* / RAS-related C3 botulinum substrate 1*  / reaction / complex
 ENSGALG00000004958 BTK / Bruton tyrosine kinase / P35991* / Q06187* / Tyrosine-protein kinase BTK *  / complex / reaction
 ENSGALG00000008016 GRB2 / growth factor receptor-bound protein 2 / P62993* / Q60631*  / reaction / complex
 ENSGALG00000014124 TEC / tyrosine-protein kinase Tec / P42680* / tec protein tyrosine kinase*  / complex
 ENSGALG00000015216 SYK / F1N9Y5 / Tyrosine-protein kinase SYK / P48025* / P43405* / spleen tyrosine kinase* / spleen associated tyrosine kinase*  / complex / reaction
 ENSGALG00000039327 VAV3 / vav guanine nucleotide exchange factor 3 / Q9R0C8* / Q9UKW4* / vav 3 oncogene*  / complex / reaction
 ENSGALG00000039775 SHC1 / SHC adaptor protein 1 / P29353* / P98083* / SHC-transforming protein 1 *  / complex / reaction
 ENSGALG00000000681 PAK1 / p21 (RAC1) activated kinase 1 / Q13153* / Mus musculus p21 protein (Cdc42/Rac)-activated kinase 1 (Pak1), transcript variant 3, mRNA.*  / reaction / complex
 ENSGALG00000006426 PAK2 / p21 (RAC1) activated kinase 2 / Q13177* / Q8CIN4* / Serine/threonine-protein kinase PAK 2 PAK-2p27 PAK-2p34*  / reaction / complex
 ENSGALG00000039450 SOS1 / SOS Ras/Rac guanine nucleotide exchange factor 1 / Q07889* / Q62245* / Son of sevenless homolog 1 *  / complex / reaction






 

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